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Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Background

Recently, triglyceride deposit cardiomyovasculopathy (TGCV) with defective intracellular lipolysis was found to be a disease that causes heart failure. As a diagnostic criterion for TGCV, an Iodaine-123-β-methyl iodophenyl-pentadecanoic acid washout rate (BMIPP WOR) of < 10% is used, but its clinical significance in patients with heart failure remains to be clarified.

Methods

In 62 hospitalized patients with chronic heart failure, 123I-BMIPP myocardial single-photon emission computed tomography (SPECT) was performed predischarge state. The prevalence of TGCV was investigated. Subsequently, follow-up was conducted for ≥ 90 days (mean: 724.6 ± 392.7 days), and the association between the BMIPP WOR and cardiac events was examined, establishing all-cause mortality and admission due to heart failure as endpoints.

Results

Of the 62 patients, the WOR was < 10% in 41 (66.1%). Of these, 26 (41.9%) were diagnosed with definite TGCV. Furthermore, cardiac events were noted in 12 patients (19.4%). Analysis with Cox proportional hazards models showed that the BMIPP WOR < 4.5% was a significant event-predicting factor [HR 4.29, 95% CI: 1.20–16.87; p = 0.0245]. On a Kaplan–Meier curve, the WOR was 4.5%; there was a significant difference in the incidence of events (p = 0.0298).

Conclusion

In the predischarge state of heart failure, 123I-BMIPP myocardial SPECT was performed. In approximately 40% of the patients, a diagnosis of TGCV was made. The results suggested that the BMIPP WOR is useful for predicting the prognosis of chronic heart failure patients regardless of TGCV.

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Data availability

The datasets during and analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

Funding

This research was supported by Nihon Medi-Physics Co. Ltd.

Author information

Authors and Affiliations

  1. Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan

    Chihiro Aoshima, Shinichiro Fujimoto, Ayako Kudo, Yuko O. Kawaguchi, Kazuhisa Takamura, Yuya Matsue, Takao Kato, Yuki Kamo, Yui O. Nozaki, Daigo Takahashi, Makoto Hiki, Takatoshi Kasai, Kazunori Shimada & Tohru Minamino

  2. Department of Radiological Technology, Juntendo University Hospital, Tokyo, Japan

    Yoshifumi Kawamura & Satoshi Kimura

  3. Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Nobuo Tomizawa & Koji Murakami

  4. Juntendo University Medical Technology Innovation Center, Tokyo, Japan

    Shuko Nojiri

  5. Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan

    Hideyuki Miyauchi

  6. Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics and Triglyceride Research Center (TGRC), Department of Triglyceride Science, Graduate School of Medicine, Osaka University, Osaka, Japan

    Ken-ichi Hirano

  7. Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo, Japan

    Tohru Minamino

Authors
  1. Chihiro Aoshima
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  2. Shinichiro Fujimoto
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  3. Ayako Kudo
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  14. Makoto Hiki
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  15. Takatoshi Kasai
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  16. Shuko Nojiri
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  17. Hideyuki Miyauchi
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  18. Ken-ichi Hirano
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  19. Kazunori Shimada
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  20. Koji Murakami
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  21. Tohru Minamino
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Corresponding author

Correspondence to Shinichiro Fujimoto.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Juntendo University Ethics Committee (16–224 on 24/01/2017). All patients received informed consent for the study and publication.

Competing interests

Dr. Fujimoto and Dr. Hirano have a research agreement with Nihon Medi-Physics Co. Ltd. Dr. Minamino has a scholarship grant with Nihon Medi-Physics Co. Ltd. All other authors declare no competing interests.

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Aoshima, C., Fujimoto, S., Kudo, A. et al. Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure. Eur J Nucl Med Mol Imaging 49, 3129–3139 (2022). https://doi.org/10.1007/s00259-022-05749-1

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  • DOI: https://doi.org/10.1007/s00259-022-05749-1

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