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Supramolecular biomaterials for bio-imaging and imaging-guided therapy

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Abstract

Benefiting from their unique advantages, including reversibly switchable structures, good biocompatibility, facile functionalization, and sensitive response to biological stimuli, supramolecular biomaterials have been widely applied in biomedicine. In this review, the representative achievements and trends in the design of supramolecular biomaterials (mainly those derived from biomacromolecules) with specific macromolecules including peptides, deoxyribonucleic acid, and polysaccharides, as well as their applications in bio-imaging and imaging-guided therapy are summarized. This review will serve as an important summary and “go for” reference for explorations of the applications of supramolecular biomaterials in bio-imaging and image-guided therapy, and will promote the development of supramolecular chemistry as an emerging interdisciplinary research area.

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Funding

This work was financially supported by the Science and Technology Development Fund (FDCT), Macau SAR (0016/2019/AKP and SKL-QRCM(UM)-2020–2022), the National Natural Science Foundation of China (21871301 and 22071275), and Macao Young Scholars Program (AM2020028).

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Author notes

  1. Beibei Xie and Yuan-Fu Ding contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, People’s Republic of China

    Beibei Xie, Yuan-Fu Ding, Mingju Shui, Ludan Yue, Cheng Gao & Ruibing Wang

  2. Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, People’s Republic of China

    Cheng Gao & Ruibing Wang

  3. Department of Chemistry, Queen’s University, Kingston, ON, K7L 3N6, Canada

    Ian W. Wyman

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  1. Beibei Xie
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  2. Yuan-Fu Ding
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  3. Mingju Shui
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  4. Ludan Yue
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Correspondence to Ruibing Wang.

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Xie, B., Ding, YF., Shui, M. et al. Supramolecular biomaterials for bio-imaging and imaging-guided therapy. Eur J Nucl Med Mol Imaging 49, 1200–1210 (2022). https://doi.org/10.1007/s00259-021-05622-7

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