Skip to main content

Advertisement

Log in

Reply to: Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring

  • Letter to the Editor
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Bengs S, Haider A, Warnock GI, Fiechter M, Pargaetzi Y, Rampidis G, et al. Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring. Eur J Nucl Med Mol Imaging. 2020. https://doi.org/10.1007/s00259-020-05106-0.

  2. Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, et al. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017;9. https://doi.org/10.1126/scitranslmed.aal2658.

  3. Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Hutt Centeno E, et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet. 2018;392:929–39. https://doi.org/10.1016/S0140-6736(18)31114-0.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Antoniades C, Shirodaria C. Detecting coronary inflammation with perivascular fat attenuation imaging. 2019;12:2011–4. doi:https://doi.org/10.1016/j.jcmg.2018.12.024.

  5. Altman DG, Royston P. The cost of dichotomising continuous variables. BMJ. 2006;332:1080. https://doi.org/10.1136/bmj.332.7549.1080.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Antoniades C, Antonopoulos AS, Deanfield J. Imaging residual inflammatory cardiovascular risk. Eur Heart J. 2020;41:748–58. https://doi.org/10.1093/eurheartj/ehz474.

    Article  CAS  PubMed  Google Scholar 

  7. Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, et al. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Eur Heart J. 2019;40:3529–43. https://doi.org/10.1093/eurheartj/ehz592.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Elnabawi Y, Oikonomou E, Dey A, Mancio J, Rodante J, Gelfand J, et al. Treatment with biologic therapy in psoriasis is associated with a reduction in coronary artery inflammation, assessed by perivascular Fat Attenuation Index. J Am Coll Cardiol. 2019;73:87. https://doi.org/10.1016/S0735-1097(19)30695-3.

  9. Dai X, Yu L, Lu Z, Shen C, Tao X, Zhang J. Serial change of perivascular fat attenuation index after statin treatment: insights from a coronary CT angiography follow-up study. Int J Cardiol. 2020;319:144–9. https://doi.org/10.1016/j.ijcard.2020.06.008.

    Article  PubMed  Google Scholar 

Download references

Funding

CA is supported by the British Heart Foundation (FS/16/15/32047 and TG/19/2/34831), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre and Innovate UK.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alexios S. Antonopoulos.

Ethics declarations

Conflict of interest

AA and CA are inventors of intellectual property relevant to CT imaging (AA/CA: GB2015/052359, GR2018/0100490, GR2018/0100510; CA: GB2015/052359, GB2016/1620494.3, GB2018/1818049.9). CA is founder, shareholder, and director of Caristo Diagnostics Ltd., a spin-out company of the University of Oxford; he is also head of Oxford Academic Cardiovascular CT Core lab.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Cardiology.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Antonopoulos, A.S., Antoniades, C. Reply to: Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring. Eur J Nucl Med Mol Imaging 48, 1707–1708 (2021). https://doi.org/10.1007/s00259-020-05171-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-020-05171-5

Navigation