Hypoglycemia-induced brain hypometabolism captured in real time by FDG-PET

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References

  1. 1.

    Association AD. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care. 2020;43:S14.

    Article  Google Scholar 

  2. 2.

    Contreras CM, Gutiérrez-García AG. Cognitive impairment in diabetes and poor glucose utilization in the intracellular neural milieu. Med Hypotheses Elsevier. 2017;104:160–5.

    CAS  Article  Google Scholar 

  3. 3.

    Bryan RM Jr, Keefer KA, MacNeill C. Regional cerebral glucose utilization during insulin-induced hypoglycemia in unanesthetized rats. J Neurochem Wiley Online Library. 1986;46:1904–11.

    CAS  Article  Google Scholar 

  4. 4.

    Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Giovanna E, et al. Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting. Neuroimage Clin. Elsevier B.V. 2014;6:445–54.

    Article  Google Scholar 

  5. 5.

    Cranston I, Reed LJ, Marsden PK, Amiel SA. Changes in regional brain 18F-fluorodeoxyglucose uptake at hypoglycemia in type 1 diabetic men associated with hypoglycemia unawareness and counter-regulatory failure. Diabetes Am Diabetes Assoc. 2001;50:2329–66.

    CAS  Google Scholar 

  6. 6.

    Teh MM, Dunn JT, Choudhary P, Samarasinghe Y, Macdonald I, O’Doherty M, et al. Evolution and resolution of human brain perfusion responses to the stress of induced hypoglycemia. Neuroimage Elsevier. 2010;53:584–92.

    Article  Google Scholar 

  7. 7.

    Bingham EM, Dunn JT, Smith D, Sutcliffe-Goulden J, Reed LJ, Marsden PK, et al. Differential changes in brain glucose metabolism during hypoglycaemia accompany loss of hypoglycaemia awareness in men with type 1 diabetes mellitus. An [11 C]-3-O-methyl-D-glucose PET study. Diabetologia. Springer. 2005;48:2080–9.

    CAS  Article  Google Scholar 

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Correspondence to Daniela Perani.

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This research study was approved by the local ethical committees, in conformity with the Helsinki Declaration.

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Informed consent was obtained from the participant before PET exam.

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Zerbini, G., Caminiti, S.P. & Perani, D. Hypoglycemia-induced brain hypometabolism captured in real time by FDG-PET. Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-020-05141-x

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