Reversible widespread brain 18F-FDG PET hypometabolism in chronic fatigue syndrome treated by hyperbaric oxygen therapy

This is a preview of subscription content, access via your institution.

Data availability

The PET data that support the findings are available from the corresponding author upon reasonable request.

References

  1. 1.

    Tirelli U, Chierichetti F, Tavio M, Simonelli C, Bianchin G, Zanco P, et al. Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data. Am J Med. 1998;105:54S–8S. https://doi.org/10.1016/s0002-9343(98)00179-x.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Siessmeier T, Nix WA, Hardt J, Schreckenberger M, Egle UT, Bartenstein P. Observer independent analysis of cerebral glucose metabolism in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry. 2003;74:922–8. https://doi.org/10.1136/jnnp.74.7.922.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Sahbai S, Kauv P, Abrivard M, Blanc-Durand P, Aoun-Sebati M, Emsen B, et al. Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI. Eur J Nucl Med Mol Imaging. 2019;46:531–2. https://doi.org/10.1007/s00259-018-4229-3.

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Efrati S, Golan H, Bechor Y, Faran Y, Daphna-Tekoah S, Sekler G, et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome--prospective clinical trial. PLoS One. 2015;10:e0127012. https://doi.org/10.1371/journal.pone.0127012.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Akarsu S, Tekin L, Ay H, Carli AB, Tok F, Simşek K, et al. The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome. Undersea Hyperb Med. 2013;40:197–200.

    PubMed  Google Scholar 

  6. 6.

    Yildiz S, Uzun G, Kiralp MZ. Hyperbaric oxygen therapy in chronic pain management. Curr Pain Headache Rep. 2006;10:95–100. https://doi.org/10.1007/s11916-006-0019-x.

    Article  PubMed  Google Scholar 

  7. 7.

    Hui J, Zhang ZJ, Zhang X, Shen Y, Gao YJ. Repetitive hyperbaric oxygen treatment attenuates complete Freund's adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord. J Pain. 2013;14:747–58. https://doi.org/10.1016/j.jpain.2013.02.003.

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Guedj E, Cammilleri S, Niboyet J, Dupont P, Vidal E, Dropinski JP, et al. Clinical correlate of brain SPECT perfusion abnormalities in fibromyalgia. J Nucl Med. 2008;49:1798–803. https://doi.org/10.2967/jnumed.108.053264.

    Article  PubMed  Google Scholar 

Download references

Funding

The local PET database of healthy controls was funded by APHM (regional PHRC; NCT00484523).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Eric Guedj.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

The case report is a retrospective observation with no ethical approval requirement other than the informed written consent.

The local PET database of healthy controls was acquired in accordance with the Declaration of Helsinki, with informed written consent of patients and approval from “CPP Sud Méditerranée V” ethics committee.

Consent to participate

Informed written consent was obtained from all individual participants included in the study.

Consent for publication

Informed written consent was obtained from all individual participants included in the study.

Code availability

Not applicable.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Neurology

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mairal, E., Barberon, B., Laine, N. et al. Reversible widespread brain 18F-FDG PET hypometabolism in chronic fatigue syndrome treated by hyperbaric oxygen therapy. Eur J Nucl Med Mol Imaging (2021). https://doi.org/10.1007/s00259-020-05122-0

Download citation