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Prognostic value of SPECT myocardial perfusion entropy in high-risk type 2 diabetic patients

  • Original Article
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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Risk stratification of patients with type 2 diabetes mellitus (T2D) remains suboptimal. We hypothesized that myocardial perfusion entropy (MPE) quantified from SPECT myocardial perfusion images may provide incremental prognostic value in T2D patients independently from myocardial ischemia.

Methods

T2D patients with very high and high cardiovascular risk were prospectively included (n = 166, 65 ± 12 years). Stress perfusion defect was quantified by visual evaluation of SPECT MPI. SPECT MPI was also used for the quantification of rest and stress MPE. The primary end point was major adverse cardiac events (MACEs) defined as cardiac death, myocardial infarction (MI), and myocardial revascularization > 3 months after SPECT.

Results

Forty-four MACEs were observed during a 4.6-year median follow-up. Significant differences in stress MPE were observed between patients with and without MACEs (4.19 ± 0.46 vs. 3.93 ± 0.40; P ≤ .01). By Kaplan-Meier analysis, the risk of MACEs was significantly higher in patients with higher stress MPE (log-rank P ≤ 01). Stress MPE and stress perfusion defect (SSS ≥ 4) were significantly associated with the risk of MACEs (hazard ratio 2.77 and 2.06, respectively, P < .05 for both) after adjustment for clinical and imaging risk predictors as identified from preliminary univariate analysis. MPE demonstrated incremental prognostic value over clinical risk factors, stress test EKG and SSS as evidenced by nested models showing improved Akaike information criterion (AIC), reclassification (global continuous net reclassification improvement [NRI]: 63), global integrated discrimination improvement (IDI: 6%), and discrimination (change in c-statistic: 0.66 vs 0.74).

Conclusions

Stress MPE provided independent and incremental prognostic information for the prediction of MACEs in diabetic patients.

Trial registration number

NCT02316054 (12/12/2014).

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Acknowledgments

Results from the present study have been partially presented at the EANM 2019 congress (presentation # EPS-087; https://link.springer.com/content/pdf/10.1007%2Fs00259-019-04486-2.pdf; https://posterng.netkey.at/eanm/viewing/index.php?module=viewing_poster&task=viewsection&ti=33880).

Author information

Author notes

  1. Laurent M. Riou and Gilles Barone-Rochette contributed equally to this work.

Authors and Affiliations

  1. Nuclear Medicine Department, Grenoble-Alpes University Hospital, Grenoble, France

    Loïc Djaileb, Nicolas De Leiris, Julien Leenhardt, Alex Calizzano & Daniel Fagret

  2. Radiopharmaceutiques Biocliniques, UMR UGA-INSERM U1039, Grenoble, France

    Loïc Djaileb, Alexandre Seiller, Marjorie Canu, Nicolas De Leiris, Julie Poujol, Alicia Fraguas-Rubio, Julien Leenhardt, Adrien Carabelli, Alex Calizzano, Marie De Fondaumière, Alexis Broisat, Gérald Vanzetto, Catherine Ghezzi, Daniel Fagret, Laurent M. Riou & Gilles Barone-Rochette

  3. Cardiology Department, Grenoble-Alpes University Hospital, Grenoble, France

    Marjorie Canu, Adrien Carabelli, Gérald Vanzetto & Gilles Barone-Rochette

  4. Cardiology Department, Clinique Mutualiste, Grenoble, France

    Alix Martin

  5. GIPSA-lab, CNRS, UMR 5216, Grenoble, France

    Michel Desvignes

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  1. Loïc Djaileb
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Correspondence to Loïc Djaileb.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the regional ethics committee (CECIC Rhône-Alpes Auvergne) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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This article is part of the Topical Collection on Cardiology

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Djaileb, L., Seiller, A., Canu, M. et al. Prognostic value of SPECT myocardial perfusion entropy in high-risk type 2 diabetic patients. Eur J Nucl Med Mol Imaging 48, 1813–1821 (2021). https://doi.org/10.1007/s00259-020-05110-4

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