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Subcortical amyloid relates to cortical morphology in cognitively normal individuals

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Abstract

Purpose

Amyloid (Aβ) brain deposition can occur in cognitively normal individuals and is associated with cortical volume abnormalities. Aβ-related volume changes are inconsistent across studies. Since volume is composed of surface area and thickness, the relative contribution of Aβ deposition on each of these metrics remains to be understood in cognitively normal individuals.

Methods

A group of 104 cognitively normal individuals underwent neuropsychological assessment, PiB-PET scan, and MRI acquisition. Surface-based cortical analyses were performed to investigate the effects of cortical and subcortical Aβ burden on cortical volume, thickness, and surface area. Mediation analyses were used to study the effect of thickness and surface area on Aβ-associated volume changes. We also investigated the relationships between structural metrics in clusters with abnormal morphology and regions underlying resting-state functional networks and cognitive performance.

Results

Cortical Aβ was not associated with cortical morphology. Subcortical Aβ burden was associated with changes in cortical volume, thickness, and surface area. Aβ-associated volume changes were driven by cortical surface area with or without thickness but never by thickness alone. Aβ-associated changes overlapped greatly with regions from the default mode network and were associated with lower performance in visuospatial abilities, episodic memory, and working memory.

Conclusions

In cognitively normal individuals, subcortical Aβ is associated with cortical volume, and this effect was driven by surface area with or without thickness. Aβ-associated cortical changes were found in the default mode network and affected cognitive performance. Our findings demonstrate the importance of studying subcortical Aβ and cortical surface area in normal ageing.

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Funding

This work was funded by the Canadian Institutes of Health Research (no. MOP123376) and the Institute of Aging (no. IA0120269). SJ was supported by a Chercheur boursier senior award from the Fonds de recherche du Québec—Santé (FRQ-S).

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Authors and Affiliations

  1. Department of Psychology, Université de Montréal, Montreal, Quebec, Canada

    Shady Rahayel, Pénélope Sévigny Dupont, Maude Joannette, Marie Maxime Lavallée & Sven Joubert

  2. Research Centre, Institut universitaire de gériatrie de Montréal, Montreal, Quebec, Canada

    Shady Rahayel, Pénélope Sévigny Dupont, Maude Joannette, Marie Maxime Lavallée & Sven Joubert

  3. Department of Neurology, Université de Sherbrooke, Sherbrooke, Quebec, Canada

    Christian Bocti

  4. Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

    Jim Nikelski & Howard Chertkow

  5. Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada

    Howard Chertkow

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  1. Shady Rahayel
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Correspondence to Shady Rahayel.

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Rahayel, S., Bocti, C., Sévigny Dupont, P. et al. Subcortical amyloid relates to cortical morphology in cognitively normal individuals. Eur J Nucl Med Mol Imaging 46, 2358–2369 (2019). https://doi.org/10.1007/s00259-019-04446-w

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