Optimal method for measuring baseline metabolic tumor volume in DLBCL patients: are statistical agreements of SUV ≥2.5 satisfactory?
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The prognostic value of the pretreatment total metabolic tumor volume (TMTV) obtained from quantitative PET measurements in patients with diffuse large B cell lymphoma (DLBCL) may vary depending on the outlining method. Therefore, a standardized methodology for TMTV quantification is needed for multicenter studies. To this end, Ilyas et al. recently compared different TMTV measurement methods, including different software algorithms , to investigate agreement between (i) in-house and commercial software, (ii) different TMTV outlining methods and (iii) different observers. Receiver operating characteristic (ROC) curves were established to identify the optimal cut-off value for each TMTV method for predicting both progression-free survival (PFS) and overall survival (OS) in patients with DLBCL. Although all methods predicted prognosis, the authors concluded that the method using a lower standardized uptake value (SUV) threshold of 2.5 g mL−1(≥2.5 method) had the best...
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The authors declare that they have no conflict of interest.
Research involving human participants and/or animals
- 1.Ilyas H, Mikhaeel NG, Dunn JT, Rahman F, Møller H, Smith D, et al. Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma. Eur J Nucl Med Mol Imaging. 2018. https://doi.org/10.1007/s00259-018-3953-z.
- 3.JCGM. Evaluation of measurement data — Guide to the expression of uncertainty in measurement. 2008. www.bipm.org, September 2008.