Optimal method for measuring baseline metabolic tumor volume in DLBCL patients: are statistical agreements of SUV ≥2.5 satisfactory?

  • Eric Laffon
  • Roger Marthan
Letter to the Editor

Dear Editor,

The prognostic value of the pretreatment total metabolic tumor volume (TMTV) obtained from quantitative PET measurements in patients with diffuse large B cell lymphoma (DLBCL) may vary depending on the outlining method. Therefore, a standardized methodology for TMTV quantification is needed for multicenter studies. To this end, Ilyas et al. recently compared different TMTV measurement methods, including different software algorithms [1], to investigate agreement between (i) in-house and commercial software, (ii) different TMTV outlining methods and (iii) different observers. Receiver operating characteristic (ROC) curves were established to identify the optimal cut-off value for each TMTV method for predicting both progression-free survival (PFS) and overall survival (OS) in patients with DLBCL. Although all methods predicted prognosis, the authors concluded that the method using a lower standardized uptake value (SUV) threshold of 2.5 g mL−1(≥2.5 method) had the best...


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The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.CHU de BordeauxBordeauxFrance
  2. 2.Univ. Bordeaux, Centre de Recherche Cardio-Thoracique de BordeauxBordeauxFrance
  3. 3.INSERM U-1045, Centre de Recherche Cardio-Thoracique de BordeauxBordeauxFrance
  4. 4.Service de Médecine NucléaireHôpital du Haut-LévèquePessacFrance

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