Skip to main content

Table 2 Sensitivity of neck ultrasonography and [18F]DOPA in the detection of regional and locoregional lymph node metastasis in all studied patients in relation to the results of histology

From: [18F]DOPA PET/ceCT in diagnosis and staging of primary medullary thyroid carcinoma prior to surgery

  DOPA PET/CT Neck ultrasonography Histology
Central regions (level VI)
 Metastatic levels (n) 8 3 15
 Sensitivity 53% (95% CI 35–53)* 20% (95% CI 7–20)  
 Specificity 100% (95% CI 84–100) 100% (95% CI 88–100)  
 PPV 100% (95% CI 65–100) 100% (95% CI 33–100)  
 NPV 71% (95% CI 59–71)* 59% (95% CI 52–59)  
 Accuracy 78% (95% CI 61–78) 63% (95% CI 50–63)  
 P value vs. histology 0.001* 0.092  
Lateral regions (levels I, II, III, IV, V)
 Metastatic levels (n) 19 10 26
 Sensitivity 73% (95% CI 60–73)* 39% (95% CI 26–39)  
 Specificity 100% (95% CI 99–100) 100% (95% CI 99–100)  
 PPV 100% (95% CI 82–100) 100% (95% CI 68–100)  
 NPV 97% (95% CI 96–97)* 94% (95% CI 93–94)  
 Accuracy 98% (95% CI 95–98)* 94% (95% CI 92–94)  
 P value vs. histology <0.001 <0.001  
All regions
 Metastatic levels (n) 27 13 41
 Sensitivity 66% (95% CI 57–66)* 32% (95% CI 23–32)  
 Specificity 100% (95% CI 99–100) 100% (95% CI 99–100)  
 PPV 100% (95% CI 86–100) 100% (95% CI 73–100)  
 NPV 95% (95% CI 94–95)* 91% (95% CI 90–91)  
 Accuracy 96% (95% CI 93–96)* 91% (95% CI 89–91)  
 P value vs. histology <0.001 <0.001  
Patient-based analysis
 Patients with LN metastases (n) 12 8 19
 Sensitivity 63% (95% CI 48–63)* 42% (95% CI 27–42)  
 Specificity 100% (95% CI 78–100) 100% (95% CI 78–100)  
 PPV 100% (95% CI 76–100) 100% (95% CI 65–100)  
 NPV 65% (95% CI 50–65) 54% (95% CI 43–54)  
 Accuracy 78% (95% CI 60–78) 66% (95% CI 48–66)  
 P value vs. histology <0.001 0.01  
 Patients with N0 (n) 20 24 13
 Patients with N1a (n) 1 1 4
 Patients with N1b (n) 11 7 15
 Patients with N1a+b (n) 7 2 11
 Patients with bilateral LN metastasis (n) 6 1 8
  1. LN lymph node, PPV positive predictive value, NPV negative predictive value
  2. *P < 0.05 vs. ultrasonography