FDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy

  • Pierre Lovinfosse
  • Zsolt Levente Janvary
  • Philippe Coucke
  • Sébastien Jodogne
  • Claire Bernard
  • Mathieu Hatt
  • Dimitris Visvikis
  • Nicolas Jansen
  • Bernard Duysinx
  • Roland Hustinx
Original Article

DOI: 10.1007/s00259-016-3314-8

Cite this article as:
Lovinfosse, P., Janvary, Z.L., Coucke, P. et al. Eur J Nucl Med Mol Imaging (2016) 43: 1453. doi:10.1007/s00259-016-3314-8

Abstract

Introduction

With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume or heterogeneity could predict the outcome in patients with non-small cell lung cancers (NSCLC) treated by stereotactic body radiation therapy (SBRT).

Methods

Sixty-three patients with NSCLC treated by SBRT underwent a 18F-FDG PET/CT before treatment. Maximum and mean standard uptake value (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), as well as 13 global, local and regional textural features were analysed. The predictive value of these parameters, along with clinical features, was assessed using univariate and multivariate analysis for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Cutoff values were obtained using logistic regression analysis, and survivals were compared using Kaplan-Meier analysis.

Results

The median follow-up period was 27.1 months for the entire cohort and 32.1 months for the surviving patients. At the end of the study, 25 patients had local and/or distant recurrence including 12 who died because of the cancer progression. None of the clinical variables was predictive of the outcome, except age, which was associated with DFS (HR 1.1, P = 0.002). None of the 18F-FDG PET/CT or clinical parameters, except gender, were associated with OS. The univariate analysis showed that only dissimilarity (D) was associated with DSS (HR = 0.822, P = 0.037), and that several metabolic measurements were associated with DFS. In multivariate analysis, only dissimilarity was significantly associated with DSS (HR = 0.822, P = 0.037) and with DFS (HR = 0.834, P < 0.01).

Conclusion

The textural feature dissimilarity measured on the baseline 18F-FDG PET/CT appears to be a strong independent predictor of the outcome in patients with NSCLC treated by SBRT. This may help selecting patients who may benefit from closer monitoring and therapeutic optimization.

Keywords

18F-FDG PET/CT Non-small cell lung cancer Stereotactic body radiation therapy Textural analysis Heterogeneity Prognostic factor 

Supplementary material

259_2016_3314_MOESM1_ESM.pdf (139 kb)
ESM 11) Formulas for tumour texture analysis (PDF 138 kb)
259_2016_3314_MOESM2_ESM.doc (60 kb)
ESM 22) Spearman’s correlation coefficients (DOC 60 kb)
259_2016_3314_MOESM3_ESM.docx (43 kb)
ESM 33) Distribution of dissimilarity with respect to MTV (DOCX 43 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Pierre Lovinfosse
    • 1
  • Zsolt Levente Janvary
    • 2
  • Philippe Coucke
    • 2
  • Sébastien Jodogne
    • 3
  • Claire Bernard
    • 1
  • Mathieu Hatt
    • 4
  • Dimitris Visvikis
    • 4
  • Nicolas Jansen
    • 2
  • Bernard Duysinx
    • 5
  • Roland Hustinx
    • 1
  1. 1.Department of Medical Physics, Division of Nuclear Medicine and Oncological ImagingCHU University of LiègeLiegeBelgium
  2. 2.Department of Medical Physics, Division of Radiation OncologyCHU and University of LiègeLiègeBelgium
  3. 3.Department of Medical Physics, CHU of LiègeLiègeBelgium
  4. 4.LaTIM, INSERM UMR 1101BrestFrance
  5. 5.Division of Pulmonology, CHU LiègeLiègeBelgium

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