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Iterative reconstruction or filtered backprojection for semi-quantitative assessment of dopamine D2 receptor SPECT studies?

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

In routine clinical practice striatal dopamine D2 receptor binding is generally assessed using data reconstructed by filtered backprojection (FBP). The aim of this study was to investigate the use of an iterative reconstruction algorithm (ordered subset expectation maximization, OSEM) and to assess whether it may provide comparable or even better results than those obtained by standard FBP.

Methods

In 56 patients with parkinsonian syndromes, single photon emission computed tomography (SPECT) scans were acquired 2 h after i.v. application of 185 MBq [123I]iodobenzamide (IBZM) using a triple-head gamma camera (Siemens MS 3). The scans were reconstructed both by FBP and OSEM (3 iterations, 8 subsets) and filtered using a Butterworth filter. After attenuation correction the studies were automatically fitted to a mean template with a corresponding 3-D volume of interest (VOI) map covering striatum (S), caudate (C), putamen (P) and several reference VOIs using BRASS software.

Results

Visual assessment of the fitted studies suggests a better separation between C and P in studies reconstructed by OSEM than FBP. Unspecific background activity appears more homogeneous after iterative reconstruction. The correlation shows a good accordance of dopamine receptor binding using FBP and OSEM (intra-class correlation coefficients S: 0.87; C: 0.88; P: 0.84). Receiver-operating characteristic (ROC) analyses show comparable diagnostic power of OSEM and FBP in the differentiation between idiopathic parkinsonian syndrome (IPS) and non-IPS.

Conclusion

Iterative reconstruction of IBZM SPECT studies for assessment of the D2 receptors is feasible in routine clinical practice. Close correlations between FBP and OSEM data suggest that iteratively reconstructed IBZM studies allow reliable quantification of dopamine receptor binding even though a gain in diagnostic power could not be demonstrated.

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References

  1. Vaamonde J, Ibañez R, García A, Poblete V. Study of the pre and post-synaptic dopaminergic system by DaTSCAN/IBZM SPECT in the differential diagnosis of parkinsonism in 75 patients. Neurologia 2004;19:292–300.

    PubMed  CAS  Google Scholar 

  2. Tissingh G, Booij J, Winogrodzka A, van Royen EA, Wolters EC. IBZM- and CIT-SPECT of the dopaminergic system in parkinsonism. J Neural Transm Suppl 1997;50:31–7.

    PubMed  CAS  Google Scholar 

  3. Cordes M, Hierholzer J, Schelosky L, Schrag A, Richter WS, Eichstädt H, et al. Iodine-123-iodo-lisuride SPECT in Parkinson’s disease. J Nucl Med 1996;37:22–5.

    PubMed  CAS  Google Scholar 

  4. Hatton RL, Hutton BF, Angelides S, Choong KK, Larcos G. Improved tolerance to missing data in myocardial perfusion SPET using OSEM reconstruction. Eur J Nucl Med Mol Imaging 2004;31:857–61.

    Article  PubMed  CAS  Google Scholar 

  5. Starck SA, Ohlsson J, Carlsson S. An evaluation of reconstruction techniques and scatter correction in bone SPECT of the spine. Nucl Med Commun 2003;24:565–70.

    Article  PubMed  Google Scholar 

  6. Kauppinen T, Koskinen MO, Alenius S, Vanninen E, Kuikka JT. Improvement of brain perfusion SPET using iterative reconstruction with scatter and non-uniform attenuation correction. Eur J Nucl Med 2000;27:1380–6.

    Article  PubMed  CAS  Google Scholar 

  7. Koch W, Hamann C, Welsch J, Pöpperl G, Radau PE, Tatsch K. Is iterative reconstruction an alternative to filtered backprojection in routine processing of dopamine transporter SPECT studies? J Nucl Med 2005;46:1804–11.

    PubMed  Google Scholar 

  8. Pareto D, Cot A, Pavía J, Falcón C, Juvells I, Lomeña F, et al. Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission SPET imaging. Eur J Nucl Med Mol Imaging 2003;30:1322–9.

    Article  PubMed  Google Scholar 

  9. Dickson JC, Tossici-Bolt L, Sera T, Erlandsson K, Varrone A, Tatsch K, et al. The impact of reconstruction method on the quantification of DaTSCAN images. Eur J Nucl Med Mol Imaging 2010;37:23–35.

    Article  PubMed  Google Scholar 

  10. Catafau AM, Bullich S, Danús M, Penengo MM, Cot A, Abanades S, et al. Test-retest variability and reliability of 123I-IBZM SPECT measurement of striatal dopamine D2 receptor availability in healthy volunteers and influence of iterative reconstruction algorithms. Synapse 2008;62:62–9.

    Article  PubMed  CAS  Google Scholar 

  11. Bullich S, Cot A, Gallego J, Gunn RN, Suáarez M, Pavía J, et al. Impact of scatter correction on D2 receptor occupancy measurements using 123I-IBZM SPECT: comparison to 11C-raclopride PET. Neuroimage 2010;50:1511–8.

    Article  PubMed  CAS  Google Scholar 

  12. Tatsch K, Asenbaum S, Bartenstein P, Catafau A, Halldin C, Pilowsky LS, et al. European Association of Nuclear Medicine procedure guidelines for brain neurotransmission SPET using (123)I-labelled dopamine D(2) transporter ligands. Eur J Nucl Med Mol Imaging 2002;29:BP30–5.

    Article  PubMed  CAS  Google Scholar 

  13. Tatsch K, Asenbaum S, Bartenstein P, Catafau A, Halldin C, Pilowsky LS, et al. European Association of Nuclear Medicine procedure guidelines for brain neurotransmission SPET using (123)I-labelled dopamine D(2) receptor ligands. Eur J Nucl Med Mol Imaging 2002;29:BP23–9.

    Article  PubMed  CAS  Google Scholar 

  14. Hudson H, Larkin R. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging 1994;13:601–9.

    Article  PubMed  CAS  Google Scholar 

  15. Koch W, Radau PE, Hamann C, Tatsch K. Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies. J Nucl Med 2005;46:1109–18.

    PubMed  Google Scholar 

  16. Metz CE. ROC methodology in radiologic imaging. Invest Radiol 1986;21:720–33.

    Article  PubMed  CAS  Google Scholar 

  17. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307–10.

    Article  PubMed  CAS  Google Scholar 

  18. Seibyl JP, Marek K, Sheff K, Baldwin RM, Zoghbi S, Zea-Ponce Y, et al. Test/retest reproducibility of iodine-123-betaCIT SPECT brain measurement of dopamine transporters in Parkinson’s patients. J Nucl Med 1997;38:1453–9.

    PubMed  CAS  Google Scholar 

  19. Gilbert P. Iterative methods for the three-dimensional reconstruction of an object from projections. J Theor Biol 1972;36:105–17.

    Article  PubMed  CAS  Google Scholar 

  20. Gordon R, Bender R, Herman GT. Algebraic reconstruction techniques (ART) for three-dimensional electron microscopy and x-ray photography. J Theor Biol 1970;29:471–81.

    Article  PubMed  CAS  Google Scholar 

  21. Shepp L, Vardi Y. Maximum likelihood reconstruction for emission tomography. IEEE Trans Med Imaging 1982;1:113–22.

    Article  PubMed  CAS  Google Scholar 

  22. Nuyts J, Dupont P, Stroobants S, Maes A, Mortelmans L, Suetens P. Evaluation of maximum-likelihood based attenuation correction in positron emission tomography. IEEE Trans Nucl Sci 1999;46:1136–41.

    Article  Google Scholar 

  23. Lange K, Carson R. EM reconstruction algorithms for emission and transmission tomography. J Comput Assist Tomogr 1984;8:306–16.

    PubMed  CAS  Google Scholar 

  24. Kauppinen T, Yang J, Kilpeläinen H, Kuikka JT. Quantitation of neuroreceptors: a need for better SPECT imaging. Nuklearmedizin 2001;40:102–6.

    PubMed  CAS  Google Scholar 

  25. Pretorius PH, King MA, Pan TS, de Vries DJ, Glick SJ, Byrne CL. Reducing the influence of the partial volume effect on SPECT activity quantitation with 3D modelling of spatial resolution in iterative reconstruction. Phys Med Biol 1998;43:407–20.

    Article  PubMed  CAS  Google Scholar 

  26. Beekman FJ, Kamphuis C, Frey EC. Scatter compensation methods in 3D iterative SPECT reconstruction: a simulation study. Phys Med Biol 1997;42:1619–32.

    Article  PubMed  CAS  Google Scholar 

  27. Hutton BF, Hudson HM, Beekman FJ. A clinical perspective of accelerated statistical reconstruction. Eur J Nucl Med 1997;24:797–808.

    PubMed  CAS  Google Scholar 

  28. Sjörgreen K, Ljungberg M, Strand SE. Parameters influencing volume and activity quantitation in SPECT. Acta Oncol 1996;35:323–30.

    Article  PubMed  Google Scholar 

  29. Van Laere KJ, Warwick J, Versijpt J, Goethals I, Audenaert K, Van Heerden B, et al. Analysis of clinical brain SPECT data based on anatomic standardization and reference to normal data: an ROC-based comparison of visual, semiquantitative, and voxel-based methods. J Nucl Med 2002;43:458–69.

    PubMed  Google Scholar 

  30. Radau PE, Linke R, Slomka PJ, Tatsch K. Optimization of automated quantification of 123I-IBZM uptake in the striatum applied to parkinsonism. J Nucl Med 2000;41:220–7.

    PubMed  CAS  Google Scholar 

  31. Radau PE, Slomka PJ, Julin P, Svensson L, Wahlund LO. Evaluation of linear registration algorithms for brain SPECT and the errors due to hypoperfusion lesions. Med Phys 2001;28:1660–8.

    Article  PubMed  CAS  Google Scholar 

  32. Slomka PJ, Radau P, Hurwitz GA, Dey D. Automated three-dimensional quantification of myocardial perfusion and brain SPECT. Comput Med Imaging Graph 2001;25:153–64.

    Article  PubMed  CAS  Google Scholar 

  33. Tatsch K. Can SPET imaging of dopamine uptake sites replace PET imaging in Parkinson’s disease? For. Eur J Nucl Med Mol Imaging 2002;29:711–4.

    Article  PubMed  Google Scholar 

  34. Van Laere K, Koole M, Kauppinen T, Monsieurs M, Bouwens L, Dierck R. Nonuniform transmission in brain SPECT using 201Tl, 153Gd, and 99mTc static line sources: anthropomorphic dosimetry studies and influence on brain quantification. J Nucl Med 2000;41:2051–62.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Munich, Marchioninistr. 15, 81377, Munich, Germany

    Walter Koch, Christine Suessmair, Klaus Tatsch & Gabriele Pöpperl

  2. Institute of Clinical Radiology, University of Munich, Munich, Germany

    Walter Koch

  3. Department of Neurology, University of Munich, Munich, Germany

    Christine Suessmair

  4. Department of Nuclear Medicine, Klinikum Karlsruhe, Karlsruhe, Germany

    Klaus Tatsch

  5. Department of Nuclear Medicine, Klinikum Stuttgart, Stuttgart, Germany

    Gabriele Pöpperl

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  1. Walter Koch
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  2. Christine Suessmair
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Correspondence to Walter Koch.

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Koch, W., Suessmair, C., Tatsch, K. et al. Iterative reconstruction or filtered backprojection for semi-quantitative assessment of dopamine D2 receptor SPECT studies?. Eur J Nucl Med Mol Imaging 38, 1095–1103 (2011). https://doi.org/10.1007/s00259-011-1737-9

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  • DOI: https://doi.org/10.1007/s00259-011-1737-9

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