Skip to main content

Advertisement

SpringerLink
Log in

Synchronous malignancies in patients with squamous cell carcinomas of the oral cavity

  • Original Article
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Synchronous malignancies in patients with squamous cell carcinomas of the oral cavity (OCSCC) are occasionally encountered. In the current study we tried to evaluate their frequency, detectability by 18F-fluorodeoxyglucose (FDG) studies, and prognostic factors.

Methods

A retrospective analysis of patients with primary OCSCC enrolled for 18F-FDG studies from 2002 to 2008 was performed. The detectability of synchronous second cancers by 18F-FDG studies was defined by the scoring of two interpreters. Prognostic factors for overall survival in patients receiving curative-intent treatment were assessed using the univariate Kaplan-Mayer analysis and the multivariate Cox regression model.

Results

Of 764 patients, 40 (5.2%) had synchronous malignancies. 18F-FDG studies detected 22 (48%) of 46 synchronous second cancers. For synchronous cancers at the hypopharynx, esophagus, or liver, the median survival of patients was no longer than 1 year, and the detection rates by 18F-FDG studies were 100, 86, and 25%, respectively. In the 33 patients receiving curative-intent treatment, the site of second cancer, complete surgical resection of all known tumors, and the oral habit of betel quid/areca nut chewing are significant prognostic factors in the univariate analysis, while the site of second cancer is the only significant prognostic factor in the multivariate analysis (p = 0.041).

Conclusion

The site of second cancer is the most significant prognostic factor in OCSCC patients with synchronous malignancies receiving curative-intent treatment. 18F-FDG studies detect synchronous malignancies with poor prognosis in OCSCC patients except for hepatic cancers. In OCSCC patients with synchronous malignancies with poor prognosis, prospective studies comparing different treatment options should be further conducted.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Commonly diagnosed cancers worldwide. Cancer Research UK. http://info.cancerresearchuk.org/cancerstats/world/commoncancers/index.htm. Accessed 15 Sep 2010.

  2. Kademani D. Oral cancer. Mayo Clin Proc 2007;82:878–87.

    Article  PubMed  Google Scholar 

  3. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45:309–16.

    Article  PubMed  Google Scholar 

  4. Day GL, Blot WJ. Second primary tumors in patients with oral cancer. Cancer 1992;70:14–9.

    Article  PubMed  CAS  Google Scholar 

  5. Cianfriglia F, Di Gregorio DA, Manieri A. Multiple primary tumours in patients with oral squamous cell carcinoma. Oral Oncol 1999;35:157–63.

    Article  PubMed  CAS  Google Scholar 

  6. van Oijen MGCT, Slootweg PJ. Oral field cancerization: carcinogen-induced independent events or micrometastatic deposits? Cancer Epidemiol Biomarkers Prev 2000;9:249–56.

    PubMed  Google Scholar 

  7. Liao C-T, Kang C-J, Chang JT-C, Wang H-M, Ng S-H, Hsueh C, et al. Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area. Oral Oncol 2007;43:811–9.

    Article  PubMed  Google Scholar 

  8. Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, et al. SEER cancer statistics review, 1975–2007, National Cancer Institute. Based on November 2009 SEER data submission, posted to the SEER web site, 2010. http://seer.cancer.gov/csr/1975_2007/. Accessed 15 Sep 2010.

  9. Ko Y-C, Huang Y-L, Lee C-H, Chen M-J, Lin L-M, Tsai C-C. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 1995;24:450–3.

    Article  PubMed  CAS  Google Scholar 

  10. Lim SG, Mohammed R, Yuen M-F, Kao J-H. Prevention of hepatocellular carcinoma in hepatitis B virus infection. J Gastroenterol Hepatol 2009;24:1352–7.

    Article  PubMed  Google Scholar 

  11. Khan MA, Combs CS, Brunt EM, Lowe VJ, Wolverson MK, Solomon H, et al. Positron emission tomography scanning in the evaluation of hepatocellular carcinoma. J Hepatol 2000;32:792–7.

    Article  PubMed  CAS  Google Scholar 

  12. Strobel K, Haerle S, Stoeckli S, Schrank M, Soyka J, Veit-Haibach P, et al. Head and neck squamous cell carcinoma (HNSCC)—detection of synchronous primaries with (18)F-FDG-PET/CT. Eur J Nucl Med Mol Imaging 2009;36:919–27.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank all the members of the cross-disciplinary team for head and neck cancers in our institution for their devotion and help.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Chiayi, Taiwan

    Feng-Yuan Liu

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan

    Chun-Ta Liao

  3. Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 5, Fu-Shin Street, Gueishan Township, Taoyuan County, 33305, Taiwan

    Tzu-Chen Yen

Authors
  1. Feng-Yuan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chun-Ta Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tzu-Chen Yen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tzu-Chen Yen.

Additional information

Chun-Ta Liao and Tzu-Chen Yen contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, FY., Liao, CT. & Yen, TC. Synchronous malignancies in patients with squamous cell carcinomas of the oral cavity. Eur J Nucl Med Mol Imaging 38, 1020–1028 (2011). https://doi.org/10.1007/s00259-011-1733-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-011-1733-0

Keywords

Search

Navigation