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Reliability of myocardial perfusion gated SPECT for the reproducible evaluation of resting left ventricular functional parameters in long-term follow-up

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Perfusion gated single photon emission computed tomography (SPECT) can assess with good reproducibility left ventricular (LV) volumes and ejection fraction (EF). Whether this reproducibility is maintained in long-term follow-up is unknown.

Methods

We compared LV end-diastolic (ED) and end-systolic (ES) volumes (V) as well as EF calculated using gated SPECT and QGS software in 103 coronary artery disease patients studied twice at > 1-year interval because of standard clinical indications. Patients were divided into two groups: (A) 67 patients without major clinical changes and with stable resting perfusion and (B) 36 with modified clinical status or resting perfusion.

Results

The relationship between gated SPECT 2 EF (=y) and gated SPECT 1 EF (=x) was for group A: y = 0.91 x + 5.34, r = 0.92, p < 0.0001, SEE=4 and for group B: y = 0.67 x + 13.6, r = 0.63, p < 0.0001, SEE=10. The 95% limit of agreement was 8 EF units for group A and 20.6 EF units for group B. For EDV, the 95% limit of agreement was 22 ml for group A and 52 ml for group B. For ESV, the 95% limit of agreement was 13 ml for group A and 44 ml for group B.

Conclusion

In stable patients with an unmodified resting perfusion pattern the functional parameters derived from perfusion gated SPECT have good reproducibility even after a prolonged time interval. This supports the value of gated SPECT for serial evaluations of LV function.

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Authors and Affiliations

  1. Nuclear Medicine Unit, Department of Clinical Physiopathology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy

    Roberto Sciagrà, Valentina Berti, Sabrina Genovese & Alberto Pupi

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  1. Roberto Sciagrà
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  2. Valentina Berti
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  3. Sabrina Genovese
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  4. Alberto Pupi
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Correspondence to Roberto Sciagrà.

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Sciagrà, R., Berti, V., Genovese, S. et al. Reliability of myocardial perfusion gated SPECT for the reproducible evaluation of resting left ventricular functional parameters in long-term follow-up. Eur J Nucl Med Mol Imaging 37, 1722–1729 (2010). https://doi.org/10.1007/s00259-010-1444-y

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