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Molecular imaging in cognitive impairment: the relevance of cognitive reserve, importance of multisite longitudinal trials and challenges of standardised analysis

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References

  1. Diogenes Laertius. Lives of Eminent Philosophers, trans. Robert Drew Hicks. (1925). Loeb Classical Library.

  2. Kurz A, Perneczky R. Neurobiology of cognitive disorders. Curr Opin Psychiatry. 2009;22(6):546–51.

    Article  PubMed  Google Scholar 

  3. Perneczky R, Wagenpfeil S, Lunetta KL, Cupples LA, Green RC, Decarli C, et al. Education attenuates the effect of medial temporal lobe atrophy on cognitive function in Alzheimer’s Disease: the MIRAGE study. J Alzheimers Dis. 2009;17(4):855–62.

    Google Scholar 

  4. Perneczky R, Häussermann P, Drzezga A, Boecker H, Granert O, Feurer R, et al. Fluoro-deoxy-glucose positron emission tomography correlates of impaired activities of daily living in dementia with Lewy bodies: implications for cognitive reserve. Am J Geriatr Psychiatry. 2009;17(3):188–95.

    Article  PubMed  Google Scholar 

  5. Perneczky R, Drzezga A, Boecker H, Ceballos-Baumann AO, Granert O, Förstl H, et al. Activities of daily living, cerebral glucose metabolism, and cognitive reserve in Lewy body and Parkinson’s disease. Dement Geriatr Cogn Disord. 2008;26(5):475–81.

    Article  CAS  PubMed  Google Scholar 

  6. Perneczky R, Pohl C, Bornschein S, Förstl H, Kurz A, Diehl-Schmid J. Accelerated clinical decline in well-educated patients with frontotemporal lobar degenerations. Eur Arch Psychiatry Clin Neurosci. 2009;259(6):362–7.

    Article  PubMed  Google Scholar 

  7. Stern Y. Cognitive reserve. Neuropsychologia. 2009;47(10):2015–28.

    Article  PubMed  Google Scholar 

  8. Van Horn JD, Toga AW. Multisite neuroimaging trials. Curr Opin Neurol. 2009;22(4):370–8.

    Article  PubMed  Google Scholar 

  9. Langbaum JB, Chen K, Lee W, Reschke C, Bandy D, Fleisher AS, et al. Alzheimer’s Disease neuroimaging initiative. Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Neuroimage. 2009;45(4):1107–16.

    Article  PubMed  Google Scholar 

  10. Ellis KA, Bush AI, Darby D, De Fazio D, Foster J, Hudson P, et al. The Australian imaging, biomarkers and lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1,112 individuals recruited for a longitudinal study of Alzheimer’s disease. Int Psychogeriatr. 2009;21(4):672–87.

    Article  PubMed  Google Scholar 

  11. Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer’s disease, and other dementias. J Nucl Med. 2008;49(3):390–8.

    Article  PubMed  Google Scholar 

  12. Pearlson G. Multisite collaborations and large databases in psychiatric neuroimaging: advantages, problems, and challenges. Schizophr Bull. 2009;35(1):1–2.

    Article  PubMed  Google Scholar 

  13. Joshi A, Koeppe RA, Fessler JA. Reducing between scanner differences in multi-center PET studies. Neuroimage. 2009;46(1):154–9.

    Article  PubMed  Google Scholar 

  14. Fouquet M, Desgranges B, Landeau B, Duchesnay E, Mézenge F, de la Sayette V, et al. Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer’s disease. Brain. 2009;132(Pt 8):2058–67.

    Article  PubMed  Google Scholar 

  15. Mosconi L, Mistur R, Switalski R, Tsui WH, Glodzik L, Li Y, et al. FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2009;36(5):811–22.

    Article  CAS  PubMed  Google Scholar 

  16. Jack Jr CR, Lowe VJ, Weigand SD, Wiste HJ, Senjem ML, Knopman DS, et al. Alzheimer’s disease neuroimaging initiative. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer’s disease: implications for sequence of pathological events in Alzheimer’s disease. Brain. 2009;132(Pt 5):1355–65.

    Article  PubMed  Google Scholar 

  17. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007;6(8):734–46.

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors are grateful to Ms Catherine Wrenn for her advice and skilful editorial support.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Technologies and Center of Molecular and Cellular Imaging (IMAGO), University of Milan, Milan, Italy

    Giovanni Lucignani

  2. Department of Diagnostic Services, Unit of Nuclear Medicine, San Paolo Hospital, Via Antonio di Rudinì, 8, 20142, Milan, Italy

    Giovanni Lucignani

  3. Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK

    Robert Perneczky

  4. Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

    Robert Perneczky

Authors
  1. Giovanni Lucignani
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  2. Robert Perneczky
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Corresponding author

Correspondence to Giovanni Lucignani.

Additional information

“Focus on…” abridgements aim to highlight papers published within the past year and draw extensively on the texts and summaries of the articles referenced. Less recent citations are also included when deemed useful to provide background information on the topic reviewed.

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Lucignani, G., Perneczky, R. Molecular imaging in cognitive impairment: the relevance of cognitive reserve, importance of multisite longitudinal trials and challenges of standardised analysis. Eur J Nucl Med Mol Imaging 37, 399–404 (2010). https://doi.org/10.1007/s00259-009-1361-0

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  • DOI: https://doi.org/10.1007/s00259-009-1361-0

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