Skip to main content

Advertisement

Log in

Labeling peptides with PET radiometals: Vulcan’s forge

  • Focus on
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Dijkgraaf I, Boerman OC, Oyen WJ, Corstens FH, Gotthardt M. Development and application of peptide-based radiopharmaceuticals. Anticancer Agents Med Chem 2007;7(5):543–51. Sep.

    PubMed  CAS  Google Scholar 

  2. Wadas TJ, Wong EH, Weisman GR, Anderson CJ. Copper chelation chemistry and its role in copper radiopharmaceuticals. Curr Pharm Des 2007;13(1):3–16.

    Article  PubMed  CAS  Google Scholar 

  3. Chong HS, Mhaske S, Lin M, Bhuniya S, Song HA, Brechbiel MW, et al. Novel synthetic ligands for targeted PET imaging and radiotherapy of copper. Bioorg Med Chem Lett 2007;17(22):6107–10. Epub 2007 Sep 18, Nov 15.

    Article  PubMed  CAS  Google Scholar 

  4. Win Z, Al-Nahhas A, Rubello D, Gross MD. Somatostatin receptor PET imaging with Gallium-68 labeled peptides. Q J Nucl Med Mol Imaging 2007;51(3):244–50. Epub 2007 Apr 30, Sep.

    PubMed  CAS  Google Scholar 

  5. Parry JJ, Kelly TS, Andrews R, Rogers BE. In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7–14) analogues containing different amino acid linker moieties. Bioconjug Chem 2007;18(4):1110–7. Epub 2007 May 16, Jul–Aug.

    Article  PubMed  CAS  Google Scholar 

  6. Sprague JE, Peng Y, Fiamengo AL, Woodin KS, Southwick EA, Weisman GR, et al. Synthesis, characterization and in vivo studies of Cu(II)-64-labeled cross-bridged tetraazamacrocycle-amide complexes as models of peptide conjugate imaging agents. J Med Chem 2007;50(10):2527–35. Epub 2007 Apr 26, May 17.

    Article  PubMed  CAS  Google Scholar 

  7. Garrison JC, Rold TL, Sieckman GL, Figueroa SD, Volkert WA, Jurisson SS, et al. In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems. J Nucl Med 2007;48(8):1327–37. Epub 2007 Jul 13, Aug.

    Article  PubMed  CAS  Google Scholar 

  8. Prasanphanich AF, Nanda PK, Rold TL, Ma L, Lewis MR, Garrison JC, et al. [64Cu-NOTA-8-Aoc-BBN(7–14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues. Proc Natl Acad Sci USA 2007;104(30):12462–7. Epub 2007 Jul 12, Jul 24.

    Article  PubMed  CAS  Google Scholar 

  9. Biddlecombe GB, Rogers BE, de Visser M, Parry JJ, de Jong M, Erion JL, et al. Molecular imaging of gastrin-releasing peptide receptor-positive tumors in mice using 64Cu-and 86Y-DOTA-(Pro1,Tyr4)-bombesin(1–14). Bioconjug Chem 2007;18(3):724–30. Epub 2007 Mar 23, May–Jun.

    Article  PubMed  CAS  Google Scholar 

  10. Li ZB, Cai W, Cao Q, Chen K, Wu Z, He L, et al. 64Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med 2007;48(7):1162–71. Epub 2007 Jun 15, Jul.

    Article  PubMed  CAS  Google Scholar 

  11. Cai W, Ebrahimnejad A, Chen K, Cao Q, Li ZB, Tice DA, et al. Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice. Eur J Nucl Med Mol Imaging 2007;in press.

  12. Cai W, Chen K, He L, Cao Q, Koong A, Chen X. Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody. Eur J Nucl Med Mol Imaging. 2007;34(6):850–8. Epub 2007 Jan 30, Jun.

    Article  PubMed  CAS  Google Scholar 

  13. Maecke HR, Andre JP. 68Ga-PET radiopharmacy: a generator-based alternative to 18F-radiopharmacy. Ernst Schering Res Found Workshop 2007. (62):215–42.

  14. Breeman WA, Verbruggen AM. The 68Ge/68Ga generator has high potential, but when can we use 68Ga-labelled tracers in clinical routine? Eur J Nucl Med Mol Imaging 2007;34:978–81.

    Article  PubMed  Google Scholar 

  15. Zhernosekov KP, Filosofov DV, Baum RP, Aschoff P, Bihl H, Razbash AA, et al. Processing of generator-produced 68Ga for medical application. J Nucl Med 2007;48(10):1741–8. Oct.

    Article  PubMed  CAS  Google Scholar 

  16. Azhdarinia A, Yang DJ, Chao C, Mourtada F. Infrared-based module for the synthesis of 68Ga-labeled radiotracers. Nucl Med Biol 2007;34(1):121–7. Jan.

    Article  PubMed  CAS  Google Scholar 

  17. Decristoforo C, Knopp R, von Guggenberg E, Rupprich M, Dreger T, Hess A, et al. A fully automated synthesis for the preparation of 68Ga-labelled peptides. Nucl Med Commun 2007;28(11):870–5. Nov.

    Article  PubMed  CAS  Google Scholar 

  18. Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, et al. 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 2007;48(4):508–18. Apr.

    Article  PubMed  CAS  Google Scholar 

  19. Zhang H, Schuhmacher J, Waser B, Wild D, Eisenhut M, Reubi JC, et al. DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours. Eur J Nucl Med Mol Imaging 2007;34(8):1198–208. Epub 2007 Jan 30, Aug.

    Article  PubMed  Google Scholar 

  20. Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? Eur J Nucl Med Mol Imaging 2007;34(7):982–93. Epub 2007 Jan 16, Jul.

    Article  PubMed  CAS  Google Scholar 

  21. http://en.wikipedia.org/wiki/Vulcan_%28mythology%29

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Giovanni Lucignani.

Additional information

The commentaries in this section derive from a literature search and include summaries of recently published articles compiled and linked to each other by extensive use of the text contained in the articles examined.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lucignani, G. Labeling peptides with PET radiometals: Vulcan’s forge. Eur J Nucl Med Mol Imaging 35, 209–215 (2008). https://doi.org/10.1007/s00259-007-0656-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-007-0656-2

Keywords

Navigation