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Inter-observer reproducibility in reporting on renal drainage in children with hydronephrosis: a large collaborative study

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Abstract

Purpose

The goal of this study was to evaluate the inter-observer reproducibility in reporting on renal drainage obtained during 99mTc MAG3 renography in children, when already processed data are offered to the observers.

Methods

Because web site facilities were used for communication, 57 observers from five continents participated in the study. Twenty-three renograms, including furosemide stimulation and posterect postmicturition views, covering various patterns of drainage, were submitted to the observers. Images, curves and quantitative parameters were provided. Good or almost good drainage, partial drainage and poor or no drainage were the three possible responses for each kidney.

Results

An important bias was observed among the observers, some of them more systematically reporting the drainage as being good, while others had a general tendency to consider the drainage as poor. This resulted in rather poor inter-observer reproducibility, as for more than half of the kidneys, less than 80% of the observers agreed on one of the three responses. Analysis of the individual cases identified some obvious causes of discrepancy: the absence of a clear limit between partial and good or almost good drainage, the fact of including or neglecting the effect of micturition and change of patient’s position, the underestimation of drainage in the case of a flat renographic curve, and the difficulties of interpretation in the case of a small, not well functioning kidney.

Conclusion

There is an urgent need for better standardisation in estimating the quality of drainage.

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References

  1. Tomaru Y, Inoue T, Oriuchi N, Takahashi K, Endo K. Semi-automated renal region of interest selection method using the double-threshold technique: inter-operator variability in quantitating 99 mTc-MAG3 renal uptake. Eur J Nucl Med. 1998;25:55–9.

    Article  PubMed  CAS  Google Scholar 

  2. Itoh K, Kato C, Shiga T, Tamaki N. Inter-observer variance in quantification of the renal uptake of Tc-99m MAG3 by a gamma camera method. J Nucl Med. 1996;37(Suppl):293.

    Google Scholar 

  3. Halker RK, Chrem Y, Galt JR, et al. Interoperator variability in quantitating the MAG3 renal uptake based on semiautomated and manual regions of interest. J Nucl Med. 1996;37(Suppl):293.

    Google Scholar 

  4. Britton KE, Brown NJG. Renography in obstructive nephropathy. In: Britton KE, Brown NJG, editors. Clinical Renography. London: Lloyd-Luke (medical books); 1971. p. 163–71.

    Google Scholar 

  5. Whitfield HN, Britton KE, Hendry WF, Nimmon CC, Wickham JE. The distinction between obstructive uropathy and nephropathy by radioisotope transit times. Br J Urol. 1978;50:433–6.

    PubMed  CAS  Google Scholar 

  6. Chaiwatanarat T, Padhy HK, Bomanji JB, Nimmon CC, Sonmezoglu K, Britton KE. Validation of renal output efficiency as an objective quantitative parameter in the evaluation of upper urinary tract obstruction. J Nucl Med. 1993;34:845–8.

    PubMed  CAS  Google Scholar 

  7. O’Reilly PH. Diuresis renography 8 years later: an update. J Urol. 1986;136:993–9.

    PubMed  CAS  Google Scholar 

  8. O’Reilly PH. Obstruction in adults. Introduction and the role of nuclear medicine. In: Prigent A, Piepsz A, editors. Functional imaging in nephro-urology. London: Taylor & Francis; 2006. p. 51–6.

    Google Scholar 

  9. O’Reilly PH, Testa HJ, Lawson RS, Farrar DJ, Edwards EC. Diuresis renography in equivocal urinary tract obstruction. Br J Urol. 1978;50:76–80.

    PubMed  CAS  Google Scholar 

  10. Gordon I, Mialdea-Fernandez RM, Peters AM. Pelviureteric junction obstruction. The value of a post-micturition view in 99 m Tc DTPA diuretic renography. Br J Urol. 1988;61:409–12.

    PubMed  CAS  Google Scholar 

  11. Rossleigh MA, Leighton DM, Fransworth RH. Diuresis renography: the need for an additional view after gravity-assisted drainage. Clin Nucl Med. 1993;18:210–3.

    Article  PubMed  CAS  Google Scholar 

  12. Piepsz A, Ham HR, Dobbeleir A, Hall M, Collier F. How to exclude renal obstruction in children? Comparison of intrarenal transit times, cortical times and the frusemide test. In: Joekes AM, Constable AR, Brown NJG, Tauxe WN, editors. Radionuclides in Nephrology. London: Academic; 1982. p. 199–204.

    Google Scholar 

  13. Gordon I, Colarinha P, Fettich J, Fischer S, Frökier J, Hahn K, et al. Guidelines for standard and diuretic renogram in children. Paediatric Committee of the European Association of Nuclear Medicine. Eur J Nucl Med. 2001;28:BP21–BP30.

    PubMed  CAS  Google Scholar 

  14. O’Reilly P, Aurell M, Britton K, Kletter K, Rosenthal L, Testa T. Consensus on diuresis renography for investigating the dilated upper urinary tract. Radionuclides in Nephrourology Group. Consensus Committee on Diuresis Renography. J Nucl Med. 1996;37:1872–6.

    PubMed  CAS  Google Scholar 

  15. Frokiaer J, Eskild-Jensen A, Dissing T. Antenatally diagnosed hydronephrosis: the role of nuclear medicine techniques. In: Prigent A, Piepsz A, editors. Functional Imaging in Nephro-Urology. London: Taylor & Francis; 2006. p. 103–16.

    Google Scholar 

  16. O’Reilly PH, Lawson RS, Shields RA, Testa HJ. Idiopathic hydronephrosis-the diuresis renogram: a new non-invasive method of assessing equivocal pelviureteral junction obstruction. J Urol. 1979;121:153–5.

    PubMed  CAS  Google Scholar 

  17. Wong JC, Rossleigh MA, Fornsworth RH. Utility of technetium-99 m-MAG3 diuretic renography in the neonatal period. J Nucl Med. 1995;36:2214–19.

    PubMed  CAS  Google Scholar 

  18. Adeyoju AA, Burke D, Atkinson C, McKie C, Pollard AJ, O’Reilly PH. The choice of timing for diuresis renography: the F+0 method. BJU Int. 2001;88:1–5.

    Article  PubMed  CAS  Google Scholar 

  19. Wong DC, Rossleigh MA, Farnsworth RH. Diuretic renography with the addition of quantitative gravity-assisted drainage in infants and children. J Nucl Med. 2000;41:1030–6.

    PubMed  CAS  Google Scholar 

  20. Society for Fetal Urology and Pediatric Nuclear Medicine Council-The Society of Nuclear Medicine. The “well tempered” diuretic renogram: a standard method to examine the asymptomatic neonate with hydronephrosis or hydroureterohydronephrosis. J Nucl Med. 1992;33:2047–51.

    Google Scholar 

  21. English PJ, Testa HJ, Lawson RS, Carroll RN, Edwards EC. Modified method of diuresis renography for the assessment of equivocal pelviureteric junction obstruction. Br J Urol. 1987;59:10–14.

    Article  PubMed  CAS  Google Scholar 

  22. Sfakianakis GN, Cohen DJ, Braunstein RH, Leveillee RJ, Lerner I, Bird VG, et al. MAG3-F0 scintigraphy in decision making for emergency intervention in renal colic after helical CT positive for a urolith. J Nucl Med. 2000;41:1813–22.

    PubMed  CAS  Google Scholar 

  23. Wong DC, Rossleigh MA, Fransworth RH. F+0 diuresis renography in infants and children. J Nucl Med. 1999;40:1805–11.

    PubMed  CAS  Google Scholar 

  24. Kuyvenhoven JD, Ham HR, Piepsz A. The estimation of renal transit using renography—our opinion. Nucl Med Commun. 2004;25:1223–31.

    Article  PubMed  Google Scholar 

  25. Durand E, Blaufox D, Britton K, Carlsen O, Cosgriff P, Fine E, et al. ISCORN consensus upon renal transit time measurements. Semin Nucl Med 2008 (in press).

  26. Amarante J, Anderson PJ, Gordon I. Impaired drainage on diuretic renography using half-time or pelvic excretion efficiency is not a sign of obstruction in children with a prenatal diagnosis of unilateral pelvic dilatation. J Urol. 2003;169:1828–31.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

The authors gratefully acknowledge all the observers who participated to the study.

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Correspondence to Marianne Tondeur.

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Tondeur, M., De Palma, D., Roca, I. et al. Inter-observer reproducibility in reporting on renal drainage in children with hydronephrosis: a large collaborative study. Eur J Nucl Med Mol Imaging 35, 644–654 (2008). https://doi.org/10.1007/s00259-007-0641-9

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  • DOI: https://doi.org/10.1007/s00259-007-0641-9

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