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Comparison of [177Lu-DOTA0,Tyr3]octreotate and [177Lu-DOTA0,Tyr3]octreotide: which peptide is preferable for PRRT?

European Journal of Nuclear Medicine and Molecular Imaging volume 33, pages 1346–1351 (2006)Cite this article

Abstract

Purpose

Patients with somatostatin receptor subtype 2-positive metastasised neuroendocrine tumours can be treated with [177Lu-DOTA0,Tyr3]octreotate. Some use octreotide as the peptide for peptide receptor radionuclide therapy (PRRT). We compared in seven patients [177Lu-DOTA0,Tyr3]octreotide (177Lu-DOTATOC) and [177Lu-DOTA0,Tyr3]octreotate (177Lu-DOTATATE), to see which peptide should be preferred for PRRT with 177Lu.

Methods

In the same patients, 3,700 MBq 177Lu-DOTATOC and 3,700 MBq 177Lu-DOTATATE was administered in separate therapy sessions. Amino acids were co-administered. Whole-body scanning was performed on days 1, 4 and 7 post therapy. Blood and urine samples were collected. We calculated residence times for tumours, spleen and kidneys.

Results

All patients had longer residence times in spleen, kidneys and tumours after use of 177Lu-DOTATATE (p=0.016 in each case). Comparing 177Lu-DOTATATE with 177Lu-DOTATOC, the mean residence time ratio was 2.1 for tumour, 1.5 for spleen and 1.4 for kidneys. Dose-limiting factors for PRRT are bone marrow and/or kidney dose. Although the residence time for kidneys was longer when using 177Lu-DOTATATE, the mean administered dose to tumours would still be advantageous by a factor of 1.5, assuming a fixed maximum kidney dose is reached. Plasma radioactivity after 177Lu-DOTATATE was comparable to that after 177Lu-DOTATOC. Urinary excretion of radioactivity was comparable during the first 6 h; thereafter there was a significant advantage for 177Lu-DOTATOC.

Conclusion

177Lu-DOTATATE had a longer tumour residence time than 177Lu-DOTATOC. Despite a longer residence time in kidneys after 177Lu-DOTATATE, tumour dose will always be higher. Therefore, we conclude that the better peptide for PRRT is octreotate.

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Acknowledgements

The authors wish to thank all supporting personnel of the Department of Nuclear Medicine, Erasmus MC, for their help and effort. Also, gratitude is expressed to Prof. H.R. Maecke, University Hospital Basel, for the supply of [DOTA0,Tyr3]octreotide.

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Author notes

  1. J. P. Esser

    Present address: Department of Nuclear Medicine, Medisch Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands

Affiliations

  1. Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands

    J. P. Esser, E. P. Krenning, J. J. M. Teunissen, P. P. M. Kooij, A. L. H. van Gameren, W. H. Bakker & D. J. Kwekkeboom

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  1. J. P. Esser
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  2. E. P. Krenning
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  3. J. J. M. Teunissen
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  4. P. P. M. Kooij
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  5. A. L. H. van Gameren
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  6. W. H. Bakker
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  7. D. J. Kwekkeboom
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Correspondence to J. P. Esser.

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Esser, J.P., Krenning, E.P., Teunissen, J.J.M. et al. Comparison of [177Lu-DOTA0,Tyr3]octreotate and [177Lu-DOTA0,Tyr3]octreotide: which peptide is preferable for PRRT?. Eur J Nucl Med Mol Imaging 33, 1346–1351 (2006). https://doi.org/10.1007/s00259-006-0172-9

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  • DOI: https://doi.org/10.1007/s00259-006-0172-9

Keywords

  • Octreotate
  • Octreotide
  • PRRT
  • Lutetium
  • Neuroendocrine tumours