Global and regional left ventricular (LV) function are important indicators of the cardiac status in patients with coronary artery disease (CAD). Therapy and prognosis are to a large extent dependent on LV function. Multi-slice computed tomography (MSCT) has already earned its place as an imaging modality for non-invasive assessment of the coronary arteries, but since retrospective gating to the patient’s ECG is performed, information on LV function can be derived.
In 49 patients with known or suspected CAD, coronary angiography with MSCT imaging was performed, in addition to gated SPECT and 2D echocardiography. LV end-diastolic and LV end-systolic volumes and LV ejection fraction were analysed with dedicated software (CMR Analytical Software System, Medis, Leiden, The Netherlands for MSCT; gated SPECT by QGS, Cedars-Sinai Medical Center, Los Angeles, CA, USA), and by the biplane Simpson’s rule for 2D echocardiography. Regional wall motion was evaluated according to a 17-segment model and a three-point score system.
Correlations were fairly good between gated SPECT and MSCT (LVEDV: r=0.65; LVESV: r=0.63; LVEF: r=0.60), and excellent between 2D echocardiography and MSCT (LVEDV: r=0.92; LVESV: r=0.93; LVEF: r=0.80). Agreement for regional wall motion was 95% (κ=0.66) between gated SPECT and MSCT, and 96% (κ=0.73) between 2D echocardiography and MSCT.
Global and regional LV function and LV volumes can be adequately assessed with MSCT. Correlations with 2D echocardiography are stronger than with gated SPECT.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Bavelaar-Croon CD, Pauwels EK, van der Wall EE. Gated single-photon emission computed tomographic myocardial imaging: a new tool in clinical cardiology. Am Heart J 2001;141:383–390
Sharir T, Germano G, Kavanagh PB, Lai S, Cohen I, Lewin HC, et al. Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation 1999;100:1035–1042
White HD, Norris RM, Brown MA, Brandt PW, Whitlock RM, Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 1987;76:44–51
Achenbach S, Giesler T, Ropers D, Ulzheimer S, Derlien H, Schulte C, et al. Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography. Circulation 2001;103:2535–2538
Kuettner A, Kopp AF, Schroeder S, Rieger T, Brunn J, Meisner C, et al. Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with angiographically proven coronary artery disease. J Am Coll Cardiol 2004;43:831–839
Schuijf JD, Bax JJ, Salm LP, Jukema JW, Lamb HJ, van der Wall EE, et al. Noninvasive coronary imaging and assessment of left ventricular function using 16-slice computed tomography. Am J Cardiol 2005;95:571–574
Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002;105:539–542
Pace L, Cuocolo A, Marzullo P, Nicolai E, Gimelli A, De Luca N, et al. Reverse redistribution in resting thallium-201 myocardial scintigraphy in chronic coronary artery disease: an index of myocardial viability. J Nucl Med 1995; 36:1968–1973
Germano G, Kiat H, Kavanagh PB, Moriel M, Mazzanti M, Su HT, et al. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 1995;36:2138–2147
Schiller NB, Acquatella H, Ports TA, Drew D, Goerke J, Ringertz H, et al. Left ventricular volume from paired biplane two-dimensional echocardiography. Circulation 1979;60:547–555
Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307–310
Fleiss JL. Statistical methods for rates and proportions, 2nd edn. New York: Wiley; 1981. p 218
Nichols K, Tamis J, DePuey EG, Mieres J, Malhotra S, Rozanski A. Relationship of gated SPECT ventricular function parameters to angiographic measurements. J Nucl Cardiol 1998;5:295–303
Hansen CL, Crabbe D, Rubin S. Lower diagnostic accuracy of thallium-201 SPECT myocardial perfusion imaging in women: an effect of smaller chamber size. J Am Coll Cardiol 1996;28:1214–1219
Yamamuro M, Tadamura E, Kubo S, Toyoda H, Nishina T, Ohba M, et al. Cardiac functional analysis with multi-detector row CT and segmental reconstruction algorithm: comparison with echocardiography, SPECT, and MR imaging. Radiology 2005;234:381–390
Dirksen MS, Jukema JW, Bax JJ, Lamb HJ, Boersma E, Tuinenburg JC, et al. Cardiac multidetector-row computed tomography in patients with unstable angina. Am J Cardiol 2005;95:457–461
Salm LP, Schuijf JD, de Roos A, Lamb HJ, Vliegen HW, Jukema JW, et al. Global and regional left ventricular function assessment with 16-detector row CT: comparison with echocardiography and cardiovascular magnetic resonance. Eur J Echocardiogr 2005 Aug 9 [Epub ahead of print]. DOI: 10.1016/j.euje.2005.07.002
Schuijf JD, Bax JJ, Jukema JW, Lamb HJ, Vliegen HW, Salm LP, et al. Noninvasive angiography and assessment of left ventricular function using multislice computed tomography in patients with type 2 diabetes. Diabetes Care 2004;27:2905–2910
Mahnken AH, Koos R, Katoh M, Spuentrup E, Busch P, Wildberger JE, et al. Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction. Eur Radiol 2005;15:714–720
This work was financially supported by The Netherlands Heart Foundation, The Hague, The Netherlands, grant numbers 2001D032 and 2002B105.
Rights and permissions
About this article
Cite this article
Henneman, M.M., Bax, J.J., Schuijf, J.D. et al. Global and regional left ventricular function: a comparison between gated SPECT, 2D echocardiography and multi-slice computed tomography. Eur J Nucl Med Mol Imaging 33, 1452–1460 (2006). https://doi.org/10.1007/s00259-006-0158-7
- Gated SPECT
- Global left ventricular function
- Regional left ventricular function