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Respiration artifacts in whole-body 18F-FDG PET/CT studies with combined PET/CT tomographs employing spiral CT technology with 1 to 16 detector rows

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Abstract

Purpose

Co-registration accuracy in combined whole-body (WB) PET/CT imaging is impaired by respiration-induced mismatches between the CT and the PET. Furthermore, PET/CT misregistration may bias the PET tracer distribution following CT-based attenuation correction (CT-AC). With the introduction of multi-row CT technology of up to 16 detector rows into PET/CT designs, we investigated the incidence of respiration artifacts in WB PET/CT examinations of patients who were unable to follow any breath-hold instructions.

Methods

A total of 80 WB studies from six international sites operating PET/CT tomographs with 1-, 2-, 4-, 6-, 8-, and 16-row spiral CT were included. PET/CT examinations were acquired with the patients breathing normally during both the CT and the PET scan, and CT-AC was performed routinely. All studies were anonymized and reviewed independently by three radiologists and three nuclear medicine specialists. We report the frequency and severity of artifacts on CT and PET for the thorax and the abdomen.

Results

In WB PET/CT imaging of normally breathing patients, significant gains in diagnostic image quality can be expected from employing CT technology with six or more detector rows. In our study, fewer PET images appear distorted than corresponding CT images, which is due to the limited propagation of only mild CT image artifacts after the resampling of the CT-based attenuation map during CT-AC.

Conclusion

In whole-body PET/CT imaging of normally breathing patients, respiration-induced artifacts are reduced in both magnitude and prominence for PET/CT systems employing CT components of six or more detector rows.

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References

  1. Schelbert H. JNM supplement to J Nucl Med. In: Czernin J, editor. PET/CT: imaging function and structure, vol. 45. Society of Nuclear Medicine; 2004 p. 1–103S

  2. Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT tomograph for clinical oncology. J Nucl Med 2000;41:1369–79

    PubMed  Google Scholar 

  3. Beyer T, Tellmann L, Nickel I, Pietrzyk U. On the use of positioning aids to reduce mis-registration in the head/neck region of whole-body PET/CT studies. J Nucl Med 2005;46:596–602

    PubMed  Google Scholar 

  4. Goerres GW, Kamel E, Heidelberg TN, Schwitter MR, Burger C, von Schulthess GK. PET-CT image co-registration in the thorax: influence of respiration. Eur J Nucl Med 2002;29:351–60

    Article  Google Scholar 

  5. Beyer T, Antoch G, Blodgett T, Freudenberg LF, Akhurst T, Mueller S. Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology. Eur J Nucl Med 2003;30:588–96

    PubMed  Google Scholar 

  6. Osman MM, Cohade C, Nakamoto Y, Marshall LT, Leal JP, Wahl RL. Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients. J Nucl Med 2003;44:240–3

    PubMed  Google Scholar 

  7. Kinahan PE, Townsend DW, Beyer T, Sashin D. Attenuation correction for a combined 3D PET/CT scanner. Med Phys 1998;25:2046–53

    Article  PubMed  Google Scholar 

  8. Kinahan P, Hasegawa B, Beyer T. X-ray based attenuation correction for PET/CT scanners. Semin Nucl Med 2003;XXXIII:166–79

    Article  Google Scholar 

  9. Goerres GW, Burger C, Schwitter MR, Heidelberg TN, Seifert B, von Schulthess GK. PET/CT of the abdomen: optimizing the patient breathing pattern. Eur Radiol 2003;13:734–9

    Article  PubMed  Google Scholar 

  10. Hamblen SM, Lowe VJ. Clinical 18F-FDG oncology patient preparation techniques. J Nucl Med Technol 2003;31:3–10

    PubMed  Google Scholar 

  11. Antoch G, Freudenberg LS, Stattaus J, Jentzen W, Mueller SP, Debatin JF, et al. Whole-body positron emission tomography-CT: optimized CT using oral and IV contrast materials. Am J Roentgenol 2002;179:1555–60

    Google Scholar 

  12. Burger C, Goerres G, Schoenes S, Buck A, Lonn AH, Von Schulthess GK. PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients. Eur J Nucl Med 2002;29:922–7

    Article  Google Scholar 

  13. Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imag 1994;13:601–9

    Article  Google Scholar 

  14. Römer W, Chung M, Chan A, Townsend DW, Torok F, McCook B, et al. Single-detector helical CT in PET-CT: assessment of image quality. Am J Roentgenol 2004;182:1571–7

    Google Scholar 

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Acknowledgements

We thank Karin Stein (Siemens Molecular Imaging, Knoxville, USA) for helping us with the collection of the data. We thank the PET/CT technologists in the contributing centers for assisting with the data acquisition.

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Correspondence to Thomas Beyer.

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Beyer, T., Rosenbaum, S., Veit, P. et al. Respiration artifacts in whole-body 18F-FDG PET/CT studies with combined PET/CT tomographs employing spiral CT technology with 1 to 16 detector rows. Eur J Nucl Med Mol Imaging 32, 1429–1439 (2005). https://doi.org/10.1007/s00259-005-1879-8

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  • DOI: https://doi.org/10.1007/s00259-005-1879-8

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