Negendank W. Studies of human tumors by MRS—a review. NMR Biomed 1992;5:303–24.
Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 1999;59:80–4.
Bhakoo KK, Williams SR, Florian CL, Land H, Noble MD. Immortalization and transformation are associated with specific alterations in choline metabolism. Cancer Res 1996;56:4630–5.
Kotzerke J, Prang J, Neumaier B, Volkmer B, Guhlmann A, Kleinschmidt K, et al. Experience with carbon-11 choline positron emission tomography in prostate carcinoma. Eur J Nucl Med 2000;27:1415–9.
Ohtani T, Kurihara H, Ishiuchi S, Saito N, Oriuchi N, Inoue T, et al. Brain tumour imaging with carbon-11 choline: comparison with FDG PET and gadolinium-enhanced MR imaging. Eur J Nucl Med 2001;28:1664–70.
Kobori D, Kirihara Y, Kosaka N, Hara T. Positron emission tomography of esophageal carcinoma using C-11-choline and F-18-fluorodeoxyglucose—a novel method of preoperative lymph node staging. Cancer 1999;86:1638–48.
Hara T, Inagaki K, Kosaka N, Morita T. Sensitive detection of mediastinal lymph node metastasis of lung cancer with C-11-choline PET. J Nucl Med 2000;41:1507–13.
Liu D, Hutchinson OC, Osman S, Price P, Workman P, Aboagye EO. Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin. Br J Cancer 2002;87:783–9.
Zeisel SH. Choline phospholipids—signal transduction and carcinogenesis FASEB J 1993;7:551–7.
Wettstein M, Weik C, Holneicher C, Haussinger D. Betaine as an osmolyte in rat liver: metabolism and cell-to-cell interactions. Hepatology 1998;27:787–93.
Tijburg LBM, Geelen MJH, Vangolde LMG. Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes. Biochem Biophys Res Commun 1989;160:1275–80.
Kalra R, Wade KE, Hands L, Styles P, Camplejohn R, Greenall M, et al. Phosphomonoester is associated with proliferation in human breast cancer—a P-31 MRS study. Br J Cancer 1993;67:1145–53.
Smith TAD, Eccles S, Ormerod MG, Tombs AJ, Titley JC, McCready VR. The phospholcholine and glycerophosphorylcholine content of an oestrogen-sensitive rat mammary tumour correlates strongly with growth. Br J Cancer 1991;64:821–6.
Daly PF, Lyon RC, Faustino PJ, Cohen JS. Phospholipid metabolism in cancer cells monitored by P-31 NMR-spectroscopy. J Biol Chem 1987;262:14875–8.
Smith TAD, Eccles S, Box G, Titley JC, Leach MO, McCready VR. Phosphocholine content of rat sarcoma cells in the presence and absence of serum. Anticancer Res 1996;16:1389–92.
Smith TAD, Glaholm J, Leach MO, Machin L, Collins DJ, Payne GS, et al. A comparison of in-vivo and in-vitro 31P NMR spectra from human breast tumours: variations in phosphorus metabolism. Br J Cancer 1991;63:514–6.
Warden CH, Friedkin M. Regulation of choline kinase activity and phosphatidylcholine biosynthesis by mitogenic growth factors in 3T3 fibroblasts. J Biol Chem 1985;260:6006–11.
Hara T, Kosaka N, Shinoura N, Kondo T. PET imaging of brain tumor with [methyl-C-11]choline. J Nucl Med 1997;38:842–7.
Roivainen A, Forsback S, Gronroos T, Lehikoinen P, Kahkonen M, Sutinen E, et al. Blood metabolism of [methyl-11C]choline; implications for in-vivo imaging with positron emission tomography. Eur J Nucl Med 2000;27:25–32.
Graham RA, Meyer RA, Szwergold BS, Brown TR. Observation of myoinositol 1,2-(cyclic) phosphate in a Morris hepatoma by P-31 NMR. J Biol Chem 1987;262:35–7.
Ramirez de Molina A, Gutierrez R, Ramos MA, Silva JM, Silva J, Bonilla F, et al. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene 2002;21:4317–22.
Liscovitch M, Freese A, Blusztajn JK, Wurtman RJ. High performance liquid chromatography of water-soluble choline metabolites. Anal Biochem 1985;151:182–7.
Hoffmann K, Grafe F, Wohlrab W, Neubert RH, Brandsch M. Functional characterization of a high-affinity choline transport system in human keratinocytes. J Invest Dermatol 2002;119:118–21.
Chung TW, Huang JS, Mukherjee JJ, Crilly KS, Kiss Z. Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I. Cell Signal 2000;12:279–88.
Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E, Degani H. Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res 2002;62:1966–70.
Warden CH, Friedkin M. Regulation of phosphatjdylcholine biosynthesis by mitogenic growth factors. Biochim Biophys Acta 1984;792:270–80.
Paddon HB, Vigo C, Vance DE. Diethylstilbestrol treatment increases the amount of choline kinase in rooster liver. Biochim Biophys Acta 1982;710:112–5.
Ko KWS, Cook HW, Vance DE. Reduction of phosphatidylcholine turnover in a nb-2 lymphoma cell line after prolactin treatment—a novel mechanism for control of phosphatidylcholine levels in cells. J Biol Chem 1986;261:7846–52.
Katz-Brull R, Degani H. Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res 1996;16:1375–80.
Utriainen M, Komu M, Vuorinen V, Lehikoinen P, Sonninen P, Kurki T, et al. Evaluation of brain tumor metabolism with [11C]choline PET and 1H-MRS. J Neurooncol 2003;62:329–38.
Lockman PR, Allen DD. The transport of choline. Drug Dev Ind Pharm 2002;28:749–71.
Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994;372:549–52.
Koepsell H. Organic cation transporters in intestine, kidney, liver, and brain. Ann Rev Physiol 1998;60:243–66.
Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, et al. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 1997;16:871–81.
Sinclair CJ, Chi KD, Subramanian V, Ward KL, Green RM. Functional expression of a high affinity mammalian hepatic choline/organic transporter. J Lipid Res 2000;41:1841–48.
Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, et al. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem 1996;271:32599–604.
Okuda M, Urakami Y, Saito H, Inui K-I. Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta 1999;1417:224–31.
Wonderlin WF, Woodfork KA, Strobl JS. Changes in membrane potential during the progression of MCF7 human mammary tumor cells through the cell cycle. J Cell Physiol 1995;165:177–85.
DeGrado TR, Baldwin SW, Wang S, Orr MD, Liao RP, Friedman HS, et al. Synthesis and evaluation of 18F-labeled choline analogues as oncologic PET tracers. J Nucl Med 2001;42:1805–14.
DeGrado TR, Coleman RE, Wang S, Baldwin SW, Orr MD, Robertson CN, et al. Synthesis and evaluation of 18F-labeled choline analogues as an oncologic for positron emission tomography: initial findings in prostate cancer. Cancer Res 2000;61:110–7.
DeGrado TR, Reiman RE, Price DT, Wang S, Coleman RE. Pharmacokinetics and radiation dosimetry of 18F-fluorocholine. J Nucl Med 2002;43:92–6.