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Receptor radionuclide therapy with 90Y-[DOTA]0-Tyr3-octreotide (90Y-DOTATOC) in neuroendocrine tumours

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Abstract

Somatostatin receptors are over-expressed in many tumours, mainly of neuroendocrine origin, thus enabling treatment with somatostatin analogues. Almost a decade of clinical experience of receptor radionuclide therapy with the analogue 90Y-[DOTA]0-Tyr3-octreotide [90Y-DOTATOC] has now been obtained at a few centres of excellence. This review reports on the present state of the art of receptor radionuclide therapy and discusses new perspectives.

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Acknowledgements

The authors thank Daria Handkiewicz-Junak, Maribel Lopera Sierra, Helmut R Mäcke and Filippo de Braud for their invaluable help in the preparation of this manuscript. The authors thank William Russell-Edu for his kind assistance in revising the English of this manuscript and Mrs. Deborah Console for the editing. This work was supported by grants from the Italian Association for Cancer Research (AIRC), the Italian National Council for Research (PSO CNR-MIUR) and the Italian Ministry of Health.

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Authors and Affiliations

  1. Nuclear Medicine Division, European Institute of Oncology, via Ripamonti 435, 20141, Milan, Italy

    Lisa Bodei, Chiara Grana, Paola Rocca, Mirco Bartolomei, Marco Chinol & Giovanni Paganelli

  2. Medical Physics Division, European Institute of Oncology, Milan, Italy

    Marta Cremonesi

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  1. Lisa Bodei
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Correspondence to Giovanni Paganelli.

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Bodei, L., Cremonesi, M., Grana, C. et al. Receptor radionuclide therapy with 90Y-[DOTA]0-Tyr3-octreotide (90Y-DOTATOC) in neuroendocrine tumours. Eur J Nucl Med Mol Imaging 31, 1038–1046 (2004). https://doi.org/10.1007/s00259-004-1571-4

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