Skip to main content


Log in

Clinical usefulness of 99mTc-EDDA/HYNIC-TOC scintigraphy in oncological diagnostics: a preliminary communication

  • Short Communication
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript


This study assessed the clinical usefulness of a new technetium-99m labelled somatostatin analogue from the standpoint of oncological diagnostics. The study group comprised 40 patients in whom malignant neoplasms (32 primary and 8 metastatic) had been diagnosed. Among the primary tumours there were 21 cases of lung cancer (2 small cell and 19 non-small cell), seven pituitary adenomas (five hormonally active and two inactive), one liposarcoma, two carcinoids and one breast carcinoma. The metastatic tumours consisted of three malignant melanomas, one phaeochromocytoma, one prostatic cancer, one leiomyosarcoma, one pancreatic carcinoma ectopically secreting ACTH and one carcinoid of the thymus. The radiopharmaceutical 99mTc-EDDA/HYNIC-Tyr3-octreotide was administered i.v. at an activity of 740–925 MBq. The imaging comprised a whole-body scan and a single-photon emission tomography acquisition. Positive scintigrams were obtained in all cases of small cell and non-small cell lung cancer, four out of five hormonally active pituitary adenomas, one out of two cases of carcinoid, the liposarcoma and the breast cancer. Neoplastic metastases were visualised in two out of three patients with melanoma and in patients with phaeochromocytoma, ACTH-secreting pancreatic carcinoma and thymic carcinoid. Scintigrams were negative in both hormonally inactive pituitary adenomas, in one case of metastatic malignant melanoma, in the leiomyosarcoma and in the case of metastasis from prostatic carcinoma. The results of this pilot study indicate that 99mTc-EDDA/HYNIC-TOC is a potentially useful radiopharmaceutical for imaging of a wide range of primary and metastatic tumours. Special attention should be paid to the successful imaging of all cases of non-small cell lung cancer .

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4A, B.


  1. Krenning EP, Kwekkeboom DJ, Bakker WH, Breeman WAP, Kooji PPM, Oei HY, van Hagen M, Postema PTE, de Jong M, Reubi JC, Visser TJ, Reijs AEM, Hofland LJ Koper JW., Lamberts SWJ. Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med 1993; 20:716–731.

    CAS  PubMed  Google Scholar 

  2. Reubi JC, Waser B, Schaer JC, Laissue JA. Somatostatin receptor sst1–sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur J Nucl Med 2001; 28:836–846.

    CAS  PubMed  Google Scholar 

  3. Reubi JC, Schar JC, Waser B, Wenger S, Heppeler A, Schmitt JS, Maecke H. Affinity profiles for human somatostatin receptor subtypes SST1–SST5 of somatostatin tracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med 2000; 27:273–282.

    CAS  PubMed  Google Scholar 

  4. Kwekkeboom DJ, Krenning EP. Somatostatin receptor imaging. Semin Nucl Med 2002; 32:84–91.

    Article  PubMed  Google Scholar 

  5. Vallabhajosula S, Moyer BR, Lister-James J, McBride WJ, Lipszyc H, Lee H, Bastidas D, Dean RT. Preclinical evaluation of technetium-99m-labeled somatostatin receptor binding peptides. J Nucl Med 1996; 37:1016–1022.

    CAS  PubMed  Google Scholar 

  6. Maecke HR, Béhé M. New octreotide derivatives labelled with technetium-99m [abstract]. J Nucl Med 1996; 37:1144.

    Google Scholar 

  7. Decristoforo C, Melendez-Alafort L, Sosabowski JK, Mather SJ.99mTc-HYNIC-[Tyr3]-octreotide for imaging of somatostatin-receptor-positive tumors: preclinical evaluation and comparison with 111In-octreotide. J Nucl Med 2000; 41:1114–1119.

    CAS  PubMed  Google Scholar 

  8. Decristoforo C, Mather SJ, Cholewinski W, Donnemiller E, Riccabona G, Moncayo R.99mTc-EDDA/HYNIC-TOC: a new 99mTc-labelled radiopharmaceutical for imaging somatostatin receptor-positive tumours: first clinical results and intra-patient comparison with 111In-labelled octreotide derivatives. Eur J Nucl Med 2000; 27:1318–1325.

    CAS  PubMed  Google Scholar 

  9. Reubi JC, Waser B, Sheppard M, Macaulay V. Somatostatin receptors are present in small-cell but not in non-small-cell primary lung carcinomas: relationship to EGF-receptors. Int J Cancer 1990; 45:269–274.

    CAS  PubMed  Google Scholar 

  10. Sagman U, Mullen JB, Kovacs K, Kerbel R, Ginsberg R, Reubi JC. Identification of somatostatin receptors in human small cell lung carcinoma. Cancer 1990; 66:2129–2133.

    CAS  PubMed  Google Scholar 

  11. Kwekkeboom DJ, Kho GS, Lamberts SWJ, Reubi CJ, Laissue JA, Krenning EP. The value of octrotide scintigraphy in patients with lung cancer. Eur J Nucl Med 1994; 21:1106–1113.

    Google Scholar 

  12. O'Byrne KJ, Halmos G, Pinski J, Groot K, Szepeshazi K, Schally AV, Carney DN. Somatostatin receptor expression in lung cancer. Eur J Cancer 1994; 30A:1682–1687.

    CAS  PubMed  Google Scholar 

  13. Traub T, Petkov V, Ofluoglu S, Pangerl T, Rederer M, Fueger J, Schima W, Kurtaran A, Dudczak R, Virgolini I.111In-DOTA-lanreotide scintigraphy in patients with tumors of the lung. J Nucl Med 2001; 42:1309–1315.

    CAS  PubMed  Google Scholar 

  14. Blum J, Handmaker H, Lister-James J, Rinne N. A multicenter trial with a somatostatin analog99mTc depreotide in the evaluation of solitary pulmonary nodules. Chest 2000; 117:1232–1238.

    CAS  PubMed  Google Scholar 

  15. Van der Harst E, de Herder WW, Bruining HA. [(123)I]Metaiodobenzylguanidine and [(111)In]octreotide uptake in benign and malignant pheochromocytomas. J Clin Endocrinol Metab 2001; 86:685–693.

    PubMed  Google Scholar 

  16. Hoefnagel CA, Rankin EM, Valdes O. Sensitivity versus specificity in melanoma imaging using iodine-123 iodobenzamide and indium-111 pentetreotide. Eur J Nucl Med 1994; 21:587–588.

    CAS  PubMed  Google Scholar 

Download references


This study was supported in part by COST ACTION B 12 "Radiotracers for in vivo assessment of biological function", Working Group 3 "Radiolabelled biologically active peptides".

Author information

Authors and Affiliations


Corresponding author

Correspondence to Anna Płachcińska.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Płachcińska, A., Mikołajczak, R., Maecke, H.R. et al. Clinical usefulness of 99mTc-EDDA/HYNIC-TOC scintigraphy in oncological diagnostics: a preliminary communication. Eur J Nucl Med Mol Imaging 30, 1402–1406 (2003).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: