Skip to main content


Log in

Does diabetes affect [18F]FDG standardised uptake values in lung cancer?

  • Original Article
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript


The correlation of hyperglycaemia with decreased 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake by tumours in positron emission tomography (PET) imaging has been clearly established. The available data are mainly based on non-diabetic (non-DM) patients exposed to acute hyperglycaemia after glucose infusion, and little is known about the effect of diabetes mellitus (DM) on FDG uptake by tumours. In this retrospective study we performed a comparison of the tumour uptake in 40 DM patients with the tumour uptake in 145 non-DM patients, all with primary lung malignancies. Peak standardised uptake values (SUVs) without glucose correction were calculated for the lung lesions. Mean (±standard deviation) blood glucose concentrations were 6.58±2.46 mmol/l in the DM patients and 4.39±0.89 mmol/l in the non-DM patients. There was no significant difference between tumour SUVs in DM patients (79 lesions), 5.86±3.97, and those in non-DM patients (234 lesions), 6.47±4.61. There was no significant difference between tumour SUVs in DM patients with blood glucose <7 mmol/l (n=28, 64 lesions), 5.91±3.98, and those in DM patients with blood glucose >7 mmol/l (n=12, 15 lesions), 5.68±4.09. There was also no significant difference between myocardial SUVs in the DM patients (n=40), 3.28±2.75, and in a similar group of non-DM patients (n=42), 3.30±2.24. We conclude that FDG uptake in lung tumours is not significantly influenced by blood glucose levels in diabetic patients whose blood glucose levels are reasonably well controlled.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations


Additional information

Electronic Publication

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gorenberg, M., Hallett, W.A. & O'Doherty, M.J. Does diabetes affect [18F]FDG standardised uptake values in lung cancer?. Eur J Nucl Med 29, 1324–1327 (2002).

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: