Abstract
Introduction
Image-guided spine injections are an important tool in the management of patients with a variety of spinal pathologies. Our practice offers radiologist-performed fluoroscopy-guided interlaminar cervical epidural steroid injection (ESI) routinely performed in the outpatient setting. The purpose of this study was to evaluate clinical outcomes and improvement in pain scores after radiologist-performed cervical ESI.
Methods
An institutional database was used to retrospectively identify cervical injections performed between October 2016 and October 2022. All injections were performed at the C7-T1 level utilizing 1.0 mL of 10 mg/mL dexamethasone without epidural anesthetic. The Numerical Rating Scale (NRS) was used to assess pain improvement. Cervical MRI was reviewed to assess pre-injection cervical disease severity. Patient charts were reviewed for any post-injection complications.
Results
A total of 251 cervical injections in 186 patients met our inclusion criteria with mean clinical follow up of 28.5 months (range 0.2 – 73.0 months). No patients experienced any major complications after injection. Post-injection pain scores were available for 218 of 251 injections (86.9%) with mean follow-up of 11.8 days (range 6 – 57 days). There was a significant improvement in pain scores from a mean pre-injection NRS score of 5.2/10 to 3.0/10 (p < .0001). 117 patients (53.7%) reported ≥ 50% improvement after injection. Patients who had prior injection were more likely to report ≥ 50% pain improvement after subsequent injection (p = .012).
Conclusion
Radiologist-performed fluoroscopy-guided interlaminar cervical ESI at the C7-T1 level is a safe and effective tool in the management of patients with cervical pathology.
Similar content being viewed by others
Data availability
Due to the nature of research protected by HIPAA standards and IRB restrictions, data is only available to the authors approved on the IRB and thus supporting data is not available.
References
Peloso P, Gross A, Haines T, Trinh K, Goldsmith CH, Burnie S. Medicinal and injection therapies for mechanical neck disorders. Cochrane Database Syst Rev. 2007;(3):Cd000319. https://doi.org/10.1002/14651858.CD000319.pub4 (in eng)
Benyamin RM, Singh V, Parr AT, Conn A, Diwan S, Abdi S. Systematic review of the effectiveness of cervical epidurals in the management of chronic neck pain. Pain Physician. 2009;12(1):137–57 (in eng).
Binder AI. Cervical spondylosis and neck pain. BMJ. 2007;334(7592):527–31. https://doi.org/10.1136/bmj.39127.608299.80. (in eng).
Cohen SP. Epidemiology, diagnosis, and treatment of neck pain. Mayo Clin Proc. 2015;90(2):284–99. https://doi.org/10.1016/j.mayocp.2014.09.008. (in eng).
Palmer WE. Spinal injections for pain management. Radiology. 2016;281(3):669–88. https://doi.org/10.1148/radiol.2016152055. (in eng).
Manchikanti L, Pampati V, Hirsch JA. Retrospective cohort study of usage patterns of epidural injections for spinal pain in the US fee-for-service Medicare population from 2000 to 2014. BMJ Open. 2016;6(12):e013042. https://doi.org/10.1136/bmjopen-2016-013042. (in eng).
Van Boxem K, Huntoon M, Van Zundert J, Patijn J, van Kleef M, Joosten EA. Pulsed radiofrequency: a review of the basic science as applied to the pathophysiology of radicular pain: a call for clinical translation. Reg Anesth Pain Med. 2014;39(2):149–59. https://doi.org/10.1097/aap.0000000000000063. (in eng).
Shim E, Lee JW, Lee E, Ahn JM, Kang Y, Kang HS. Fluoroscopically guided epidural injections of the cervical and lumbar spine. Radiographics. 2017;37(2):537–61. https://doi.org/10.1148/rg.2017160043. (in eng).
Deshmukh S, Youngner J, Garg A. Fluoroscopy-guided spine injections: establishing a successful service in your radiology department or practice. Skeletal Radiol. 2020;49(3):475–9. https://doi.org/10.1007/s00256-019-03319-5. (in eng).
Engel A, King W, MacVicar J. The effectiveness and risks of fluoroscopically guided cervical transforaminal injections of steroids: a systematic review with comprehensive analysis of the published data. Pain Med. 2014;15(3):386–402. https://doi.org/10.1111/pme.12304. (in eng).
Chang-Chien GC, Knezevic NN, McCormick Z, Chu SK, Trescot AM, Candido KD. Transforaminal versus interlaminar approaches to epidural steroid injections: a systematic review of comparative studies for lumbosacral radicular pain. Pain Phys. 2014;17(4):E509-24 (in eng).
Strub WM, Brown TA, Ying J, Hoffmann M, Ernst RJ, Bulas RV. Translaminar cervical epidural steroid injection: short-term results and factors influencing outcome. J Vasc Interv Radiol. 2007;18(9):1151–5. https://doi.org/10.1016/j.jvir.2007.06.011. (in eng).
House LM, Barrette K, Mattie R, McCormick ZL. Cervical epidural steroid injection: techniques and evidence. Phys Med Rehabil Clin N Am. 2018;29(1):1–17. https://doi.org/10.1016/j.pmr.2017.08.001. (in eng).
Kang Y, et al. New MRI grading system for the cervical canal stenosis. AJR Am J Roentgenol. 2011;197(1):W134–40. https://doi.org/10.2214/AJR.10.5560.
McGrath JM, Schaefer MP, Malkamaki DM. Incidence and characteristics of complications from epidural steroid injections. Pain Med. 2011;12(5):726–31. https://doi.org/10.1111/j.1526-4637.2011.01077.x. (in eng).
Schultz DM, Hagedorn JM, Abd-Elsayed A, Stayner S. Safety of interlaminar cervical epidural injections: experience with 12,168 procedures in a single pain clinic. Pain Physician. 2022;25(1):49–58 (in eng).
Manchikanti L, Malla Y, Cash KA, Pampati V. Do the gaps in the ligamentum flavum in the cervical spine translate into dural punctures? An analysis of 4,396 fluoroscopic interlaminar epidural injections. Pain Physician. 2015;18(3):259–66 (in eng).
Manchikanti L, et al. Do cervical epidural injections provide long-term relief in neck and upper extremity pain? A systematic review. Pain Physician. 2015;18(1):39–60 (in eng).
Landa J, Kim Y. Outcomes of interlaminar and transforminal spinal injections. Bull NYU Hosp Jt Dis. 2012;70(1):6–10 (in eng).
Chou R, et al. Epidural corticosteroid injections for radiculopathy and spinal stenosis: a systematic review and meta-analysis. Ann Intern Med. 2015;163(5):373–81. https://doi.org/10.7326/m15-0934. (in eng).
Amrhein TJ, Bozdogan E, Vekaria S, Patel P, Lerebours R, Luo S, Kranz PG. Cross-sectional CT assessment of the extent of injectate spread at CT fluoroscopy-guided cervical epidural interlaminar steroid injections. Radiology. 2019;292(3):723–9.
Derby R, Lee SH, Kim BJ, Chen Y, Seo KS. Complications following cervical epidural steroid injections by expert interventionalists in 2003. Pain Physician. 2004;7(4):445–9 (in eng).
Huston CW. Cervical epidural steroid injections in the management of cervical radiculitis: interlaminar versus transforaminal. A review. Curr Rev Musculoskelet Med. 2009;2(1):30–42. https://doi.org/10.1007/s12178-008-9041-4. (in eng).
Cushman DM, et al. Prospective evaluation of pain flares and time until pain relief following musculoskeletal corticosteroid injections. Sports Health. 2023;15(2):227–33. https://doi.org/10.1177/19417381221076470. (in eng).
Funding
All authors did not receive grant support or research funding related to this article and do not have any proprietary interests in the materials described in this article.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Guntin, J., Regalado, L., Serhal, A. et al. Safety outcomes and improvement in pain scores after radiologist-performed fluoroscopy-guided interlaminar cervical epidural steroid injection. Skeletal Radiol 53, 1145–1152 (2024). https://doi.org/10.1007/s00256-023-04548-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00256-023-04548-5