Abstract
Chondroblastoma is a rare benign tumor, typically presenting in the first two decades. Systemic metastases in chondroblastoma are extremely rare and it is the rarity of these metastases which lead the World Health Organisation to re-classify this lesion from “intermediate” to “benign” in its updated classification of bone tumors in 2020. We present an unusual case of a 55 year-old male patient who presented with multiple FDG-avid bone lesions on a background of conventional chondroblastoma of the rib excised at another institution 11-years previously. Two of these lesions were also histologically-proven as conventional chondroblastoma at biopsy. This case highlights that, although rare, metastases can be seen in patients with chondroblastoma. To our knowledge, this is the only case with an unusual pattern of metastases limited to bone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Change history
22 November 2023
A Correction to this paper has been published: https://doi.org/10.1007/s00256-023-04520-3
References
Amary F, Bloem JL, Cleven AHG, Konishi E. Chondroblastoma. In: WHO Classification of Tumours Editorial Board. WHO classification of soft tissue and bone tumours, 5th ed. Lyon, France: IARC Press. 2020.
Pope T, Bloem HL, Beltran J, Morrison WB, Wilson DJ. Musculoskeletal Imaging. Second Edition. 2015. Chapter 92. Primary Bone Tumors pp 942–943.
Bloem JL, Mulder JD. Chondroblastoma: a clinical and radiological study of 104 cases. Skeletal Radiol. 1985;14:1–9.
Turcotte RE, Kurt AM, Sim FH, et al. Chondroblastoma. Hum Pathol. 1993;24:944–9.
Czerniak B. Dorfman and Czervak’s Bone Tumours. Second Edition. 2016. Chapter 6 Benign Cartilage Lesions pp 356–473.
Roberts PF, Taylor JG. Multifocal benign chondroblastomas: report of a case. Hum Pathol. 1980;11:296–8.
Dahlin DC, Ivins JC. Benign chondroblastoma. A study of 125 cases. Cancer. 1972;30(2):40113. https://doi.org/10.1002/10970142(197208)30:2<401::aidcncr2820300216>3.0.co;2-b.
Lu C, Ramirez D, Hwang S, Jungbluth A, Frosina D, Ntiamoah P, et al. Histone H3K36M mutation and trimethylation patterns in chondroblastoma. Histopathology. 2019;74:291–9.
Jee WH, Park YK, McCauley TR, et al. Chondroblastoma: MR characteristics with pathologic correlation. J Computer Assisted Tomography. 1999;23:721–6.
Ma JL, Wu Y, Wen JX, et al. Images of giant cell tumor and chondroblastoma around the knee: retrospective analysis of 99 cases. Quant Imaging Med Surg. 2023;13(2):787.
Oxtoby JW, Davies AM. MRI characteristics of chondroblastoma. Clin Radiol. 1996;51(22–6):95.
Yamamura S, Sato K, Sugiura H, Iwata H. Inflammatory reaction in chondroblastoma. Skeletal Radiol. 1996;25(371–6):96.
Kaim AH, Hugli R, Bonel HM, Jundt G. Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation. Skeletal Radiol. 2002;31:88–95.
John I, Inwards CY, Wenger DE, Williams DD, Fritchie KJ. Chondroblastomas presenting in adulthood: a study of 39 patients with emphasis on histological features and skeletal distribution. Histopathology. 2020;76(2):308–17.
Angelini A, Hassani M, Mavrogenis AF, Trovarelli G, Romagnoli C, Berizzi A, Ruggieri P. Chondroblastoma in adult age. Eur J Orthop Surg Traumatol. 2017;27:843–9.
Ozkoc G, Gonlusen G, Ozalay M, Kayaselcuk F, Pourbagher A, Tandogan RN. Giant chondroblastoma of the scapula with pulmonary metastases. Skelet Radiol. 2006;35(1):42–8.
Dhanda S, Menon S, Gulia A. Atypical giant chondroblastoma mimicking a chondrosarcoma. J Cancer Res Ther. 2015;11(3):660.
Kyriakos M, Land VJ, Penning HL, Parker SG. Metastatic chondroblastoma report of a fatal case with a review of the literature on atypical, aggressive, and malignant chondroblastoma. Cancer. 1985;55:1770–89.
Sohn SH, Koh SA, Kim DG, Park SW, Lee KH, Kim MK, Choi JH, Hyun MS. A case of spine origin chondroblastoma metastasis to lung. Cancer Res Treat. 2009;41(4):241–4. https://doi.org/10.4143/crt.2009.41.4.241.
Jambhekar NA, Desai PB, Chitale DA, Patil P, Arya S. Benign metastasizing chondroblastoma: a case report. Cancer. 1998;82(4):675–8.
Baumhoer D, Harder D, Ameline B, Dawson H, Kollar A. Metastasizing chondroblastoma: a rare bone tumor no longer supported by the WHO classification. Skeletal Radiol. 2021;50:255–60. https://doi.org/10.1007/s00256-020-03525-6.
Schaefer IM, Fletcher JA, Nielsen GP, Shih AR, Ferrone ML, Hornick JL, Qian X. Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. Cancer Cytopathol. 2018;126(8):552–66. https://doi.org/10.1002/cncy.22000.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
The authors have no conflicts of interest to declare.
Ethical considerations
Informed consent was obtained from the subject described in this report.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The original version of this article was revised. The third sentence of the abstract reads : "We present an usual case of a 55 year-old male patient ... " and should read "We present an unusual case of a 55 year-old male patient ....".
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Murphy, J., Patel, A., Hughes, S. et al. Bone metastases from chondroblastoma: a rare pattern of metastatic disease in an adult. Skeletal Radiol 53, 1219–1224 (2024). https://doi.org/10.1007/s00256-023-04491-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00256-023-04491-5