Abstract
Objective
Percutaneous sacroplasty is a minimally invasive procedure which utilises injection of bone cement into the sacrum for stabilisation of osteoporotic sacral insufficiency fractures (SIF) and neoplastic lesions to relieve pain and improve function. While effective, cement leakage is an important complication associated with the procedure. This study aims to compare the incidence and patterns of the cement leakages following sacroplasty for SIF versus neoplasia and discuss the various patterns of cement leakage and their implications.
Materials and methods
This retrospective study analysed 57 patients who underwent percutaneous sacroplasty at a tertiary orthopaedic hospital. Patients were divided into 2 groups of SIF (n=46) and neoplastic lesions (n=11) based on their indication for sacroplasty. Pre- and post-procedural CT fluoroscopy was used to assess for cement leakage. The incidence and patterns of cement leakage were both compared among the two groups. A Fisher’s exact test was used for statistical analysis.
Results
Eleven (19%) patients had cement leakage on post-procedural imaging. The most common sites of cement leakage were into the presacral region (6), followed by sacroiliac joints (4), sacral foramina (3) and posterior sacral (1). There was a statistically significant higher incidence of leakage in the neoplastic group in comparison to SIF group (P-value <0.05). The incidence of cement leakage in the neoplastic group was 45% (n = 5/11) versus SIF 13% (n=6/46).
Conclusion
There was a statistically significant higher incidence of cement leak in sacroplasties conducted for the treatment of neoplastic lesions compared to those with sacral insufficiency fracture.
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References
Barber SM, Livingston AD, Cech DA. Sacral radiculopathy due to cement leakage from percutaneous sacroplasty, successfully treated with surgical decompression. J Neurosurg Spine. 2013;18(5):524–8. https://doi.org/10.3171/2013.2.SPINE12497.
Mahmood B, Pasternack J, Razi A, Saleh A. Safety and efficacy of percutaneous sacroplasty for treatment of sacral insufficiency fractures: a systematic review. J Spine Surg. 2019;5(3):365–71. https://doi.org/10.21037/jss.2019.06.05.
Whitlow CT, Mussat-Whitlow BJ, Mattern CW, Baker MD, Morris PP. Sacroplasty versus vertebroplasty: comparable clinical outcomes for the treatment of fracture-related pain. AJNR Am J Neuroradiol. 2007;28(7):1266–70. https://doi.org/10.3174/ajnr.
Bastian JD, Keel MJ, Heini PF, Seidel U, Benneker LM. Complications related to cement leakage in sacroplasty. Acta Orthop Belg. 2012;78(1):100–5.
Lee J, Lee E, Lee JW, Kang Y, Ahn JM, Kang HS. Percutaneous sacroplasty: effectiveness and long-term outcome predictors. J Korean Neurosurg Soc. 2020;63(6):747–56. https://doi.org/10.3340/jkns.2020.0014.
Gupta AC, Chandra RV, Yoo AJ, Leslie-Mazwi TM, Bell DL, Mehta BP, Vanderboom TL, Rabinov JD, Larvie M, Hirsch JA. Safety and effectiveness of sacroplasty: a large single-center experience. AJNR. 2014;35(11):2202–6. https://doi.org/10.3174/ajnr.a4027.
Beall DP, Shonnard NH, Shonnard MC, Yoon ES, Norwitz J, Phillips JE, Phillips TR. An interim analysis of the first 102 patients treated in the prospective vertebral augmentation sacroplasty fracture registry. J Vasc Interv Radiol. 2023;S1051-0443(23):00356. https://doi.org/10.1016/j.jvir.2023.05.024.
Laredo JD, Hamze B. Complications of percutaneous vertebroplasty and their prevention. Semin Ultrasound CT MR. 2005;26(2):65–80. https://doi.org/10.1053/j.sult.2005.02.003.
Saad A, Botchu R, James S. The rates of cement leakage following vertebroplasty in osteoporotic versus metastatic disease. Indian J Radiol Imaging. 2022;32(1):46–50. https://doi.org/10.1055/s-0042-1744122.
Denis F, Davis S, Comfort T. Sacral fractures: an important problem. Retrospective analysis of 236 cases. Clin Orthop Relat Res. 1988;227:67–81.
Khalilzadeh O, Baerlocher MO, Shyn PB, Connolly BL, Devane AM, Morris CS, Cohen AM, Midia M, Thornton RH, Gross K, Caplin DM, Aeron G, Misra S, Patel NH, Walker TG, Martinez-Salazar G, Silberzweig JE, Nikolic B. Proposal of a new adverse event classification by the Society of Interventional Radiology Standards of Practice Committee. J Vasc Interv Radiol. 2017;28(10):1432–1437.e3. https://doi.org/10.1016/j.jvir.2017.06.019.
Baldwin MJ, Tucker LJ. Sacral insufficiency fractures: a case of mistaken identity. Int Med Case Rep J. 2014;30(7):93–8. https://doi.org/10.2147/IMCRJ.S60133.
Sun M, Zuo D, Wang H, Sheng J, Ma X, Wang C, Zan P, Hua Y, Sun W, Cai Z. Surgical treatment of sacral metastatic tumors. Front Oncol. 2021;25(11):640933. https://doi.org/10.3389/fonc.2021.640933.
Garant M. Sacroplasty: a new treatment for sacral insufficiency fracture. J Vasc Interv Radiol. 2002;13(12):1265–7. https://doi.org/10.1016/s1051-0443(07)61976-9.
Dehdashti AR, Martin JB, Jean B, Rüfenacht DA. PMMA cementoplasty in symptomatic metastatic lesions of the S1 vertebral body. Cardiovasc Intervent Radiol. 2000;23(3):235–7. https://doi.org/10.1007/s002700010052.
Rapan S, Jovanović S, Gulan G, Boschi V, Kolarević V, Dapić T. Vertebroplasty--high viscosity cement versus low viscosity cement. Coll Antropol. 2010;34(3):1063–7.
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Ariyaratne, S., Whittaker, P., James, S. et al. Comparison of patterns and rates of cement leakage in percutaneous sacroplasty for sacral insufficiency fractures versus neoplasia. Skeletal Radiol 53, 93–98 (2024). https://doi.org/10.1007/s00256-023-04386-5
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DOI: https://doi.org/10.1007/s00256-023-04386-5