Abstract
Substantial advances in percutaneous minimally invasive musculoskeletal oncologic interventions including thermal ablation and vertebral augmentation offer a robust armamentarium for interventional radiologists for management of patients with spinal metastases. Such interventions have proved safe and effective in management of selected patients with vertebral metastases. Special attention to procedure techniques including choice of ablation modality, vertebral augmentation technique, and thermal protection is essential for improved patient outcomes. Familiarity with the described interventions and implementation of procedural safety measures will further enhance the role of radiologists in the management of patients with spinal metastases. This article provides a review of the most recent advances in thermal ablation and vertebral augmentation as well as the role of radiologists for treatment of spinal metastases.
Similar content being viewed by others
References
https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2022/2022-cancer-facts-and-figures.pdf. Accessed 12 April 2022.
Macedo F, Ladeira K, Pinho F, et al. Bone metastases: an overview. Oncol Rev. 2017;11:321.
Urch C. The pathophysiology of cancer-induced bone pain: current understanding. Palliat Med. 2004;18:267–74.
Strander H, Turesson I, Cavallin-Ståhl E. A systematic overview of radiation therapy effects in soft tissue sarcomas. Acta Oncol. 2003;42:516–31.
van der Linden YM, Steenland E, van Houwelingen HC, Dutch Bone Metastasis Study Group, et al. Patients with a favourable prognosis are equally palliated with single and multiple fraction radiotherapy: results on survival in the Dutch Bone Metastasis Study. Radiother Oncol. 2006;78:245–53.
Paice JA. Cancer pain management and the opioid crisis in America: how to preserve hard-earned gains in improving the quality of cancer pain management. Cancer. 2018;124(12):2491–7.
Anchala PR, Irving WD, Hillen TJ, et al. Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device: a multicenter retrospective study. Pain Physician. 2014;17:317–27.
Bagla S, Sayed D, Smirniotopoulos J, et al. Multicenter prospective clinical series evaluating radiofrequency ablation in the treatment of painful spine metastases. Cardiovasc Intervent Radiol. 2016;39:1289–97.
Tomasian A, Hillen TJ, Chang RO, Jennings JW. Simultaneous bipedicular radiofrequency ablation combined with vertebral augmentation for local tumor control of spinal metastases. AJNR. 2018;39:1768–73.
Wallace AN, Tomasian A, Vaswani D, Vyhmeister R, Chang RO, Jennings JW. Radiographic local control of spinal metastases with percutaneous radiofrequency ablation and vertebral augmentation. AJNR. 2016;37:759–65.
Tomasian A, Wallace A, Northrup B, Hillen TJ, Jennings JW. Spine cryoablation: pain palliation and local tumor control for vertebral metastases. AJNR. 2016;37:189–95.
Auloge P, Cazzato RL, Rousseau C, et al. Complications of percutaneous bone tumor cryoablation:a 10-year experience. Radiology. 2019;291:521–8.
Khan MA, Deib G, Deldar B, Patel AM, Barr JS. Efficacy and safety of percutaneous microwave ablation and cementoplasty in the treatment of painful spinal metastases and myeloma. AJNR. 2018;39:1376–83.
Tomasian A, Gangi A, Wallace AN, Jennings JW. Percutaneous thermal ablation of spinal metastases: recent advances and review. AJR. 2018;210:142–52.
McMenomy BP, Kurup AN, Johnson GB, et al. Percutaneous cryoablation of musculoskeletal oligometastatic disease for complete remission. J Vasc Interv Radiol. 2013;24:207–13.
Cazzato RL, Auloge P, De Marini P, et al. Percutaneous image-guided ablation of bone metastases:local tumor control in oligometastatic patients. Int J Hyperthermia. 2018;35:493–9.
Levy J, Hopkins T, Morris J, et al. Radiofrequency ablation for the palliative treatment of bone metastases: outcomes from the multicenter OsteoCool tumor ablation post-market study (OPuS One study) in 100 Patients. J Vasc Interv Radiol. 2020;31(11):1745–52.
Cazzato RL, Palussière J, Auloge P, et al. Complications following percutaneous image-guided radiofrequency ablation of bone tumors:a 10-year dual-center experience. Radiology. 2020;296(1):227–35.
Pusceddu C, Sotgia B, Fele RM, Ballicu N, Melis L. Combined microwave ablation and cementoplasty in patients with painful bone metastases at high risk of fracture. Cardiovasc Intervent Radiol. 2016;39:74–80.
Venier A, Roccatagliata L, Isalberti M, et al. Armed kyphoplasty: an indirect central canal decompression technique in burst fractures. Am J Neuroradiol. 2019;40(11):1965–72.
Wallace AN, Robinson CG, Meyer J, et al. The Metastatic Spine Disease Multidisciplinary Working Group algorithms. Oncologist. 2015;20:1205–15.
Saliou G, Kocheida EM, Lehmann P, et al. Percutaneous vertebroplasty for pain management in malignant fractures of the spine with epidural involvement. Radiology. 2010;254(3):882–90.
Dalton BE, Kohm AC, Miller LE, Block JE, Poser RD. Radiofrequency targeted vertebral augmentation versus traditional balloon kyphoplasty: radiographic and morphologic outcomes of an ex vivo biomechanical pilot study. Clin Interv Aging. 2012;7:525–31.
Wallace AN, Greenwood TJ, Jennings JW. Radiofrequency ablation and vertebral augmentation for palliation of painful spinal metastases. J Neurooncol. 2015;124:111–8.
Tsoumakidou G, Koch G, Caudrelier J, et al. Image-guided spinal ablation: a review. CardiovascIntervent Radiol. 2016;39:1229–38.
Kastler A, Alnassan H, Aubry S, Kastler B. Microwave thermal ablation of spinal metastatic bone tumors. J Vasc Interv Radiol. 2014;25:1470–5.
Tomasian A, Marlow J, Hillen TJ, Jennings JW. Complications of percutaneous radiofrequency ablation of spinal osseous metastases: an 8-year single-center experience. AJR Am J Roentgenol. 2021;216(6):1607–13.
Cazzato RL, Jennings JW, Autrusseau PA, et al. Percutaneous image-guided cryoablation of spinal metastases: over 10-year experience in two academic centers. Eur Radiol. 2022;32:4137–46.
Chen L, Hou G, Zhang K, et al. Percutaneous CT-Guided microwave ablation combined with vertebral augmentation for treatment of painful spinal metastases. AJNR Am J Neuroradiol. 2022;43(3):501–6.
National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology: adult cancer pain, version 1.2022. https://www.nccn.org. Accessed 4 September 2022.
Expert Panels on Neurological Imaging, Interventional Radiology, and Musculoskeletal Imaging, Shah LM, Jennings JW, Kirsch CFE, et al. ACR appropriateness criteria: management of vertebral compression fractures. J Am Coll Radiol. 2018;15(suppl 11):S347–64.
Schag CC, Heinrich RL, Ganz PA. Karnofsky performance status revisited: reliability, validity, and guidelines. J Clin Oncol. 1984;2:187–93.
Fisher CG, DiPaola CP, Ryken TC, et al. A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group. Spin (Phila Pa 1976). 2010;35:E1221–9.
Patchell RA, Tibbs PA, Regine WF, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet. 2005;366:643–8.
Singh S, Saha S. Electrical properties of bone: a review. Clin Orthop Relat Res. 1984;186:249–71.
Cox BW, Spratt DE, Lovelock M, et al. International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2012;83:e597–605.
Weld KJ, Landman J. Comparison of cryoablation, radiofrequency ablation and high-intensity focused ultrasound for treating small renal tumours. BJU Int. 2005;96:1224–9.
Sørensen ST, Kirkegaard AO, Carreon L, Rousing R, Andersen MØ. Vertebroplasty or kyphoplasty as palliative treatment for cancer-related vertebral compression fractures: a systematic review. Spine J. 2019;19(6):1067–107.
Berenson J, Pflugmacher R, Jarzem P, et al. Cancer Patient Fracture Evaluation (CAFE) investigators. Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial. Lancet Oncol. 2011;12(3):225–35.
Buy X, Tok CH, Szwarc D, Bierry G, Gangi A. Thermal protection during percutaneous thermal ablation procedures: interest of carbon dioxide dissection and temperature monitoring. Cardiovasc Intervent Radiol. 2009;32:529–34.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Jack W. Jennings: Stryker, Varian, Boston Scientific, Merit Medical (consultant for all). Anderanik Tomasian declares no competing interests.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Key points
• Percutaneous minimally invasive thermal ablation and vertebral augmentation offer a robust armamentarium for radiologists for management of patients with spinal metastases.
• The treatment goals of thermal ablation in patients with spinal metastases are to achieve pain palliation and local tumor control, along with cure in patients with oligometastatic disease.
• Implementation of procedural safety factors is critical to minimize potential adverse effects and improve patient outcomes.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Tomasian, A., Jennings, J.W. Spine metastases: thermal ablation and augmentation. Skeletal Radiol 52, 1921–1928 (2023). https://doi.org/10.1007/s00256-023-04348-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00256-023-04348-x