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Symptom-imaging correlation in lumbar spine pain

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Abstract

Lumbar spine MRI is associated with a high prevalence of morphological abnormalities in both symptomatic and asymptomatic individuals. A difficult challenge, therefore, is distinguishing the relevant findings causing symptoms from incidental findings. The accurate diagnosis of pain generator is important because misdiagnosis can negatively impact patient management and outcome. Spine physicians use clinical symptoms and signs to interpret lumbar spine MRI and make treatment decisions. Symptom-MRI correlation enables the targeted inspection of images for pain generator. Radiologists can also use clinical information to improve diagnostic confidence and the value of dictated reports. Because high-quality clinical information may be difficult to obtain, radiologists often generate lists of lumbar spine abnormalities that are otherwise difficult to rank as pain generators. Based on the literature review, this article attempts to distinguish the MRI abnormalities that may represent incidental findings from the abnormalities that are more commonly associated with lumbar spine-related symptoms.

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References

  1. Wu A, March L, Zheng X, Huang J, Wang X, Zhao J, et al. Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017. Ann Transl Med. 2020;8:299.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Deyo RA, Mirza SK, Turner JA, Martin BI. Overtreating chronic back pain: time to back off? J Am Board Fam Med JABFM. 2009;22:62–8.

    Article  PubMed  Google Scholar 

  3. Hrudey WP. Overdiagnosis and overtreatment of low back pain: long-term effects. J Occup Rehabil. 1991;1:303–12.

    Article  CAS  PubMed  Google Scholar 

  4. Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med. 1994;331:69–73.

    Article  CAS  PubMed  Google Scholar 

  5. Jarvik JG, Deyo RA. Diagnostic evaluation of low back pain with emphasis on imaging. Ann Intern Med. 2002;137:586–97.

    Article  PubMed  Google Scholar 

  6. Deyo RA, Weinstein JN. Low back pain. N Engl J Med Mass Med Soc. 2001;344:363–70.

    Article  CAS  Google Scholar 

  7. Chou R, Qaseem A, Snow V, Casey D, Cross JT, Shekelle P, et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007;147:478–91.

    Article  PubMed  Google Scholar 

  8. Chan V, Marro A, Rempel J, Nataraj A. Determination of dynamic instability in lumbar spondylolisthesis using flexion and extension standing radiographs versus neutral standing radiograph and supine MRI. J Neurosurg Spine. 2019;31:229–35.

    Article  Google Scholar 

  9. Thornbury JR, Fryback DG, Turski PA, Javid MJ, McDonald JV, Beinlich BR, et al. Disk-caused nerve compression in patients with acute low-back pain: diagnosis with MR, CT myelography, and plain CT. Radiology. 1993;186:731–8.

    Article  CAS  PubMed  Google Scholar 

  10. Palmer WE. Spinal injections for pain management. Radiology. 2016;281:669–88.

    Article  PubMed  Google Scholar 

  11. Balza R, Mercaldo SF, Chang CY, Huang AJ, Husseini JS, Kheterpal AB, et al. Impact of patient-reported symptom information on agreement in the MRI diagnosis of presumptive lumbar spine pain generator. AJR Am J Roentgenol. 2021;217:947–56.

    Article  PubMed  Google Scholar 

  12. Balza R, Mercaldo SF, Chang CY, Huang AJ, Husseini JS, Kheterpal AB, et al. Observer agreement in the choice of lumbar spine injection for pain management. Skeletal Radiol. 2021;50:2495–501.

    Article  PubMed  Google Scholar 

  13. Jackson RP, Cain JE, Jacobs RR, Cooper BR, McManus GE. The neuroradiographic diagnosis of lumbar herniated nucleus pulposus: II. A comparison of computed tomography (CT), myelography, CT-myelography, and magnetic resonance imaging. Spine. 1989;14:1362–7.

    Article  CAS  PubMed  Google Scholar 

  14. de Graaf I, Prak A, Bierma-Zeinstra S, Thomas S, Peul W, Koes B. Diagnosis of lumbar spinal stenosis: a systematic review of the accuracy of diagnostic tests. Spine. 2006;31:1168–76.

    Article  PubMed  Google Scholar 

  15. Andreisek G, Hodler J, Steurer J. Uncertainties in the diagnosis of lumbar spinal stenosis. Radiology. 2011;261:681–4.

    Article  PubMed  Google Scholar 

  16. Datta JC, Janssen ME, Beckham R, Ponce C. The use of computed tomography angiography to define the prevertebral vascular anatomy prior to anterior lumbar procedures. Spine. 2007;32:113–9.

    Article  PubMed  Google Scholar 

  17. Daemi N, Ahmadian A, Mirbagheri A, Ahmadian AH, Saberi H, Amidi F, et al. Planning screw insertion trajectory in lumbar spinal fusion using pre-operative CT images. Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Int Conf. 2015;2015:3639–42.

    CAS  Google Scholar 

  18. Tomkins-Lane C, Melloh M, Wong A. Diagnostic tests in the clinical diagnosis of lumbar spinal stenosis: consensus and results of an international Delphi study. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2020;29:2188–97.

    Article  Google Scholar 

  19. Wu L, Cruz R. Lumbar spinal stenosis. StatPearls . Treasure Island (FL): StatPearls Publishing; 2022 . Available from:  http://www.ncbi.nlm.nih.gov/books/NBK531493/. Accessed 2 June 2022.

  20. Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, et al. Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. Osteoarthritis Cartilage. 2013;21:783–8.

    Article  CAS  PubMed  Google Scholar 

  21. Schizas C, Theumann N, Burn A, Tansey R, Wardlaw D, Smith FW, et al. Qualitative grading of severity of lumbar spinal stenosis based on the morphology of the dural sac on magnetic resonance images. Spine. 2010;35:1919–24.

    Article  PubMed  Google Scholar 

  22. Lee GY, Guen YL, Lee JW, Joon WL, Choi HS, Hee SC, et al. A new grading system of lumbar central canal stenosis on MRI: an easy and reliable method. Skeletal Radiol. 2011;40:1033–9.

    Article  PubMed  Google Scholar 

  23. Hamanishi C, Matukura N, Fujita M, Tomihara M, Tanaka S. Cross-sectional area of the stenotic lumbar dural tube measured from the transverse views of magnetic resonance imaging. J Spinal Disord. 1994;7:388–93.

    Article  CAS  PubMed  Google Scholar 

  24. Lee BC, Kazam E, Newman AD. Computed tomography of the spine and spinal cord. Radiology. 1978;128:95–102.

    Article  CAS  PubMed  Google Scholar 

  25. Andreisek G, Imhof M, Wertli M, Winklhofer S, Pfirrmann CWA, Hodler J, et al. A systematic review of semiquantitative and qualitative radiologic criteria for the diagnosis of lumbar spinal stenosis. AJR Am J Roentgenol. 2013;201:W735-746.

    Article  PubMed  Google Scholar 

  26. Ogikubo O, Forsberg L, Hansson T. The relationship between the cross-sectional area of the cauda equina and the preoperative symptoms in central lumbar spinal stenosis. Spine. 2007;32:1423–9.

    Article  PubMed  Google Scholar 

  27. Weiner BK, Patel NM, Walker MA. Outcomes of decompression for lumbar spinal canal stenosis based upon preoperative radiographic severity. J Orthop Surg. 2007;2:3.

    Article  PubMed Central  Google Scholar 

  28. Weber C, Giannadakis C, Rao V, Jakola AS, Nerland U, Nygaard ØP, et al. Is there an association between radiological severity of lumbar spinal stenosis and disability, pain, or surgical outcome?: a multicenter observational study. Spine. 2016;41:E78-83.

    Article  PubMed  Google Scholar 

  29. Kuittinen P, Sipola P, Saari T, Aalto TJ, Sinikallio S, Savolainen S, et al. Visually assessed severity of lumbar spinal canal stenosis is paradoxically associated with leg pain and objective walking ability. BMC Musculoskelet Disord. 2014;15:348.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Geisser ME, Haig AJ, Tong HC, Yamakawa KSJ, Quint DJ, Hoff JT, et al. Spinal canal size and clinical symptoms among persons diagnosed with lumbar spinal stenosis. Clin J Pain. 2007;23:780–5.

    Article  PubMed  Google Scholar 

  31. Zeifang F, Schiltenwolf M, Abel R, Moradi B. Gait analysis does not correlate with clinical and MR imaging parameters in patients with symptomatic lumbar spinal stenosis. BMC Musculoskelet Disord. 2008;9:89.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Sigmundsson FG, Kang XP, Jönsson B, Strömqvist B. Correlation between disability and MRI findings in lumbar spinal stenosis: a prospective study of 109 patients operated on by decompression. Acta Orthop. 2011;82:204–10.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Pfirrmann CWA, Dora C, Schmid MR, Zanetti M, Hodler J, Boos N. MR image-based grading of lumbar nerve root compromise due to disk herniation: reliability study with surgical correlation. Radiology. 2004;230:583–8.

    Article  PubMed  Google Scholar 

  34. Ekedahl H, Jönsson B, Annertz M, Frobell RB. Accuracy of clinical tests in detecting disk herniation and nerve root compression in subjects with lumbar radicular symptoms. Arch Phys Med Rehabil. 2018;99:726–35.

    Article  PubMed  Google Scholar 

  35. Kuittinen P, Sipola P, Aalto TJ, Määttä S, Parviainen A, Saari T, et al. Correlation of lateral stenosis in MRI with symptoms, walking capacity and EMG findings in patients with surgically confirmed lateral lumbar spinal canal stenosis. BMC Musculoskelet Disord. 2014;15:247.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Olmarker K, Rydevik B. Pathophysiology of sciatica. Orthop Clin North Am. 1991;22:223–34.

    Article  CAS  PubMed  Google Scholar 

  37. Weishaupt D, Zanetti M, Hodler J, Boos N. MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers. Radiology. 1998;209:661–6.

    Article  CAS  PubMed  Google Scholar 

  38. Lee YS, Choi ES, Song CJ. Symptomatic nerve root changes on contrast-enhanced MR imaging after surgery for lumbar disk herniation. AJNR Am J Neuroradiol. 2009;30:1062–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Lee S, Lee JW, Yeom JS, Kim K-J, Kim H-J, Chung SK, et al. A practical MRI grading system for lumbar foraminal stenosis. AJR Am J Roentgenol. 2010;194:1095–8.

    Article  PubMed  Google Scholar 

  40. Karppinen J, Malmivaara A, Tervonen O, Pääkkö E, Kurunlahti M, Syrjälä P, et al. Severity of symptoms and signs in relation to magnetic resonance imaging findings among sciatic patients. Spine. 2001;26:E149-154.

    Article  CAS  PubMed  Google Scholar 

  41. Rankine JJ, Fortune DG, Hutchinson CE, Hughes DG, Main CJ. Pain drawings in the assessment of nerve root compression: a comparative study with lumbar spine magnetic resonance imaging. Spine. 1998;23:1668–76.

    Article  CAS  PubMed  Google Scholar 

  42. Epstein NE. Foraminal and far lateral lumbar disc herniations: surgical alternatives and outcome measures. Spinal Cord. 2002;40:491–500.

    Article  CAS  PubMed  Google Scholar 

  43. Aota Y, Niwa T, Yoshikawa K, Fujiwara A, Asada T, Saito T. Magnetic resonance imaging and magnetic resonance myelography in the presurgical diagnosis of lumbar foraminal stenosis. Spine. 2007;32:896–903.

    Article  PubMed  Google Scholar 

  44. Moon KP, Suh KT, Lee JS. Reliability of MRI findings for symptomatic extraforaminal disc herniation in lumbar spine. Asian Spine J. 2009;3:16–20.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Santini A, Pitto RP. Extraforaminal lumbar disk herniation. Clinical features and computerized tomography. Ital J Orthop Traumatol. 1991;17:359–69.

    CAS  PubMed  Google Scholar 

  46. Byun WM, Jang HW, Kim SW. Three-dimensional magnetic resonance rendering imaging of lumbosacral radiculography in the diagnosis of symptomatic extraforaminal disc herniation with or without foraminal extension. Spine. 2012;37:840–4.

    Article  PubMed  Google Scholar 

  47. Kim SW, Kim CH, Kim MS, Jung YJ, Byun WM. Usefulness of three dimensional proset MR images for diagnosis of symptomatic L5–S1 foraminal and extraforaminal stenosis. J Korean Neurosurg Soc. 2013;54:30–3.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Byun WM, Kim JW, Lee JK. Differentiation between symptomatic and asymptomatic extraforaminal stenosis in lumbosacral transitional vertebra: role of three-dimensional magnetic resonance lumbosacral radiculography. Korean J Radiol. 2012;13:403–11.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Fujii K, Yamazaki M, Kang JD, Risbud MV, Cho SK, Qureshi SA, et al. Discogenic back pain: literature review of definition, diagnosis, and treatment. JBMR Plus. 2019;3:e10180.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Ota Y, Connolly M, Srinivasan A, Kim J, Capizzano AA, Moritani T. Mechanisms and origins of spinal pain: from molecules to anatomy, with diagnostic clues and imaging findings. Radiogr Rev Publ Radiol Soc N Am Inc. 2020;40:1163–1181.

  51. Bogduk N. On the definitions and physiology of back pain, referred pain, and radicular pain. Pain. 2009;147:17–9.

    Article  PubMed  Google Scholar 

  52. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26:1873–8.

    Article  CAS  PubMed  Google Scholar 

  53. Wuertz K, Haglund L. Inflammatory mediators in intervertebral disk degeneration and discogenic pain. Glob Spine J. 2013;3:175–84.

    Article  Google Scholar 

  54. Teraguchi M, Yim R, Cheung JP-Y, Samartzis D. The association of high-intensity zones on MRI and low back pain: a systematic review. Scoliosis Spinal Disord. 2018;13:22.

  55. Lim C-H, Jee W-H, Son BC, Kim D-H, Ha K-Y, Park C-K. Discogenic lumbar pain: association with MR imaging and CT discography. Eur J Radiol. 2005;54:431–7.

    Article  PubMed  Google Scholar 

  56. Braithwaite I, White J, Saifuddin A, Renton P, Taylor BA. Vertebral end-plate (Modic) changes on lumbar spine MRI: correlation with pain reproduction at lumbar discography. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 1998;7:363–8.

    Article  CAS  Google Scholar 

  57. Ricketson R, Simmons JW, Hauser BO. The prolapsed intervertebral disc. The high-intensity zone with discography correlation. Spine. 1996;21:2758–62.

    Article  CAS  PubMed  Google Scholar 

  58. Smith BM, Hurwitz EL, Solsberg D, Rubinstein D, Corenman DS, Dwyer AP, et al. Interobserver reliability of detecting lumbar intervertebral disc high-intensity zone on magnetic resonance imaging and association of high-intensity zone with pain and anular disruption. Spine. 1998;23:2074–80.

    Article  CAS  PubMed  Google Scholar 

  59. Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166:193–9.

    Article  CAS  PubMed  Google Scholar 

  60. Kuisma M, Karppinen J, Niinimäki J, Ojala R, Haapea M, Heliövaara M, et al. Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers. Spine. 2007;32:1116–22.

    Article  PubMed  Google Scholar 

  61. Weishaupt D, Zanetti M, Hodler J, Min K, Fuchs B, Pfirrmann CW, et al. Painful lumbar disk derangement: relevance of endplate abnormalities at MR imaging. Radiology. 2001;218:420–7.

    Article  CAS  PubMed  Google Scholar 

  62. Chung CB, Vande Berg BC, Tavernier T, Cotten A, Laredo J-D, Vallee C, et al. End plate marrow changes in the asymptomatic lumbosacral spine: frequency, distribution and correlation with age and degenerative changes. Skeletal Radiol. 2004;33:399–404.

    Article  PubMed  Google Scholar 

  63. Cho NH, Jung YO, Lim SH, Chung C-K, Kim HA. The prevalence and risk factors of low back pain in rural community residents of Korea. Spine. 2012;37:2001–10.

    Article  PubMed  Google Scholar 

  64. Allegri M, Montella S, Salici F, Valente A, Marchesini M, Compagnone C, et al. Mechanisms of low back pain: a guide for diagnosis and therapy. F1000Research; 2016. Available from:  https://f1000research.com/articles/5-1530. Accessed 29 Mar 2022.

  65. Hancock MJ, Maher CG, Latimer J, Spindler MF, McAuley JH, Laslett M, et al. Systematic review of tests to identify the disc, SIJ or facet joint as the source of low back pain. Eur Spine J. 2007;16:1539–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Cohen SP, Hurley RW, Christo PJ, Winkley J, Mohiuddin MM, Stojanovic MP. Clinical predictors of success and failure for lumbar facet radiofrequency denervation. Clin J Pain. 2007;23:45–52.

    Article  PubMed  Google Scholar 

  67. Cohen SP, Raja SN. Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology. 2007;106:591–614.

    Article  PubMed  Google Scholar 

  68. Mooney V, Robertson J. The Facet Syndrome. Clinical Orthopaedics and Related Research. 1976;115:149–57.

    Google Scholar 

  69. Wiesel SW, Tsourmas N, Feffer HL, Citrin CM, Patronas N. A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients. Spine. 1984;9:549–51.

    Article  CAS  PubMed  Google Scholar 

  70. Murtagh FR. Computed tomography and fluoroscopy guided anesthesia and steroid injection in facet syndrome. Spine. 1988;13:686–9.

    Article  CAS  PubMed  Google Scholar 

  71. Fujiwara A, Tamai K, Yamato M, An HS, Yoshida H, Saotome K, et al. The relationship between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 1999;8:396–401.

    Article  CAS  Google Scholar 

  72. Dolan AL, Ryan PJ, Arden NK, Stratton R, Wedley JR, Hamann W, et al. The value of SPECT scans in identifying back pain likely to benefit from facet joint injection. Br J Rheumatol. 1996;35:1269–73.

    Article  CAS  PubMed  Google Scholar 

  73. Lewinnek GE, Warfield CA. Facet joint degeneration as a cause of low back pain. Clin Orthop. 1986;216–22.

  74. Carrera GF, Williams AL. Current concepts in evaluation of the lumbar facet joints. Crit Rev Diagn Imaging. 1984;21:85–104.

    CAS  PubMed  Google Scholar 

  75. Jackson RP, Jacobs RR, Montesano PX. 1988 Volvo award in clinical sciences. Facet joint injection in low-back pain. A prospective statistical study. Spine. 1988;13:966–71.

    Article  CAS  PubMed  Google Scholar 

  76. Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med. 2001;134:541–9.

    Article  CAS  PubMed  Google Scholar 

  77. Taljanovic MS, Graham AR, Benjamin JB, Gmitro AF, Krupinski EA, Schwartz SA, et al. Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology. Skeletal Radiol. 2008;37:423–31.

    Article  PubMed  Google Scholar 

  78. Suri P, Dharamsi AS, Gaviola G, Isaac Z. Are facet joint bone marrow lesions and other facet joint features associated with low back pain? A pilot study PM R. 2013;5:194–200.

    PubMed  Google Scholar 

  79. Friedrich KM, Nemec S, Peloschek P, Pinker K, Weber M, Trattnig S. The prevalence of lumbar facet joint edema in patients with low back pain. Skeletal Radiol. 2007;36:755–60.

    Article  PubMed  Google Scholar 

  80. Lakadamyali H, Tarhan NC, Ergun T, Cakir B, Agildere AM. STIR sequence for depiction of degenerative changes in posterior stabilizing elements in patients with lower back pain. AJR Am J Roentgenol. 2008;191:973–9.

    Article  PubMed  Google Scholar 

  81. Mainka T, Lemburg SP, Heyer CM, Altenscheidt J, Nicolas V, Maier C. Association between clinical signs assessed by manual segmental examination and findings of the lumbar facet joints on magnetic resonance scans in subjects with and without current low back pain: a prospective, single-blind study. Pain. 2013;154:1886–95.

    Article  PubMed  Google Scholar 

  82. Madani A, Katz R, Muylem AV, Neugroschl C, Gevenois PA. Prevalence and frequency of subchondral bone marrow edema in the lumbar facet joints of asymptomatic and symptomatic individuals. Skeletal Radiol. 2020;49:1141–7.

    Article  PubMed  Google Scholar 

  83. Scheepers MS, Streak Gomersall J, Munn Z. The effectiveness of surgical versus conservative treatment for symptomatic unilateral spondylolysis of the lumbar spine in athletes: a systematic review. JBI Database Syst Rev Implement Rep. 2015;13:137–73.

    Article  Google Scholar 

  84. Kobayashi A, Kobayashi T, Kato K, Higuchi H, Takagishi K. Diagnosis of radiographically occult lumbar spondylolysis in young athletes by magnetic resonance imaging. Am J Sports Med. 2013;41:169–76.

    Article  PubMed  Google Scholar 

  85. Leone A, Cianfoni A, Cerase A, Magarelli N, Bonomo L. Lumbar spondylolysis: a review. Skeletal Radiol. 2011;40:683–700.

    Article  PubMed  Google Scholar 

  86. Garfin SR, Eismont FJ, Bell GR, Bono CM. Fischgrund J. Rothman and Simeone’s the spine. Elsevier Health Sci. 2017; p 551 (chapter 31).

  87. Dutton JA, Hughes SP, Peters AM. SPECT in the management of patients with back pain and spondylolysis. Clin Nucl Med. 2000;25:93–6.

    Article  CAS  PubMed  Google Scholar 

  88. Papanicolaou N, Wilkinson RH, Emans JB, Treves S, Micheli LJ. Bone scintigraphy and radiography in young athletes with low back pain. AJR Am J Roentgenol. 1985;145:1039–44.

    Article  CAS  PubMed  Google Scholar 

  89. Campbell RSD, Grainger AJ, Hide IG, Papastefanou S, Greenough CG. Juvenile spondylolysis: a comparative analysis of CT. SPECT and MRI Skeletal Radiol. 2005;34:63–73.

    Article  CAS  PubMed  Google Scholar 

  90. Kwong Y, Rao N, Latief K. MDCT findings in Baastrup disease: disease or normal feature of the aging spine? Am J Roentgenol. American Roentgen Ray Society. 2011;196:1156–9.

    Article  Google Scholar 

  91. Sartoris DJ, Resnick D, Tyson R, Haghighi P. Age-related alterations in the vertebral spinous processes and intervening soft tissues: radiologic-pathologic correlation. AJR Am J Roentgenol. 1985;145:1025–30.

    Article  CAS  PubMed  Google Scholar 

  92. Quinlan JF, Duke D, Eustace S. Bertolotti’s syndrome. The British editorial society of bone & joint surgery. J Bone Joint Surg Br. 2006;88:1183–6.

    Article  CAS  PubMed  Google Scholar 

  93. McGrath K, Schmidt E, Rabah N, Abubakr M, Steinmetz M. Clinical assessment and management of Bertolotti Syndrome: a review of the literature. Spine J Off J North Am Spine Soc. 2021;21:1286–96.

    Article  Google Scholar 

  94. Jancuska JM, Spivak JM, Bendo JA. A review of symptomatic lumbosacral transitional vertebrae: Bertolotti’s syndrome. Int J Spine Surg. 2015;9:42.

    Article  PubMed  PubMed Central  Google Scholar 

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Key points

• Incidental findings are difficult to distinguish from true pain generators in symptomatic individuals.

• Central canal stenosis, even when severe, correlates poorly with clinical symptoms.

• Foraminal stenosis, unless severe, correlates poorly with clinical symptoms.

• Facet joint degenerative changes are more closely associated with clinical symptoms when bone marrow edema, effusion, and periarticular inflammation correlate positively with concordant pain provocation on physical examination.

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Balza, R., Palmer, W.E. Symptom-imaging correlation in lumbar spine pain. Skeletal Radiol 52, 1901–1909 (2023). https://doi.org/10.1007/s00256-023-04305-8

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