Abstract
Objectives
To review the clinical and imaging findings of patients with remote history of intramuscular (IM) in vitro fertilization (IVF) gluteal injections, presenting with signs and symptoms of a possible gluteal soft tissue sarcoma.
Methods and methods
Retrospective review of consecutive patients with a history of prior IVF therapy referred for MRI evaluation of a gluteal soft tissue mass was performed. Six patients were reviewed, with 5 patients meeting study inclusion criteria. Imaging exams (ultrasound n = 3, MRI n = 5) were assessed for lesion location, morphology, and intrinsic imaging characteristics. One case proceeded to percutaneous biopsy with histopathologic correlation.
Results
Average patient age was 43 years (range 38–50). Mean time interval between IVF IM injections and MRI was 5.7 years (range 2.2–13 years). Clinical findings included palpable gluteal mass (5/5) and local pain (4/5). Ultrasound showed heterogeneous subcutaneous lesions with varying complex cystic/solid internal echogenicity. On MRI, each case illustrated an irregularly marginated lesion, mean maximal dimension 3.5 cm (range 1.5–5.9 cm), within the deep gluteal subcutaneous fat composed of solitary (1/5) or multifocal (4/5) lobules demonstrating internal areas of high T1 and homogeneous low T2 fat suppressed signal with surrounding peripheral reticular high T2 signal. Correlative histological assessment showed central areas with features of fat necrosis and a peripheral inflammatory rim.
Conclusions
In the setting of prior IVF therapy, imaging features of an irregularly marginated, deep subcutaneous gluteal lesion with inflammatory soft tissue changes surrounding solitary or multifocal areas of loculated fat signal may be seen as an inflammatory response to previous inadvertent subcutaneous injection(s).
Similar content being viewed by others
References
Glujovsky D, Pesce R, Sueldo C, Quinteiro Retamar AM, Hart RJ, Ciapponi A. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev. 2020;10:Art. No.: CD006359. https://doi.org/10.1002/14651858.CD006359.pub3. Accessed 19 Dec 2020.
Tomic V, Kasum M, Vucic K. The role of luteal support during IVF: a qualitative systematic review. Gynecol Endocrinol. 2019 Oct;35(10):829–34.
Practice Committee of American Society for Reproductive Medicine in collaboration with Society for Reproductive E, Infertility. Progesterone supplementation during the luteal phase and in early pregnancy in the treatment of infertility: an educational bulletin. Fertil Steril. 2008;90(5 Suppl):S150–3.
Iwase A, Ando H, Toda S, Ishimatsu S, Harata T, Kurotsuchi S, et al. Oral progestogen versus intramuscular progesterone for luteal support after assisted reproductive technology treatment: a prospective randomized study. Arch Gynecol Obstet. 2008;277(4):319–24.
Licciardi FL, Kwiatkowski A, Noyes NL, Berkeley AS, Krey LL, Grifo JA. Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study. Fertil Steril. 1999;71(4):614–8.
Chan VO, Colville J, Persaud T, Buckley O, Hamilton S, Torreggiani WC. Intramuscular injections into the buttocks: are they truly intramuscular? Eur J Radiol. 2006;58(3):480–4.
Haramati N, Lorans R, Lutwin M, Kaleya RN. Injection granulomas. Intramuscle or intrafat? Arch Fam Med. 1994;3(2):146–8.
Burbridge BE. Computed tomographic measurement of gluteal subcutaneous fat thickness in reference to failure of gluteal intramuscular injections. Can Assoc Radiol J. 2007;58(2):72–5.
Dayananda L, Belaval VV, Raina A, Chandana R. Intended intramuscular gluteal injections: are they truly intramuscular? J Postgrad Med. 2014;60(2):175–8.
Soliman E, Ranjan S, Xu T, Gee C, Harker A, Barrera A, et al. A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry. Biodes Manuf. 2018;1(3):161–70.
Walla A, Bakoma B, Egbohou P. Intrafat sequestration of artemisinin disguised as a purulent collection during a posterolateral hip approach. Case Rep Orthop. 2019;2019:6984875. https://doi.org/10.1155/2019/6984875. Accessed 19 Dec 2020.
Chan CCW, Ng EHY, Chan MMY, Tang OS, Lau EYL, Yeung WSB, et al. Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women. Hum Reprod. 2003;18(11):2294–7.
Dangle P, Palit V, Sundaram SK, Weston P. Noninfective cutaneous granuloma with leuprorelin acetate--reality or myth. Urology. 2007;69(4):779 e5–6.
Michaels L, Poole RW. Injection granuloma of the buttock. Can Med Assoc J. 1970;102(6):626–8.
Hizawa K, Inaba H, Nakanishi S, Otsuka H, Izumi K. Subcutaneous pseudosarcomatous polyvinylpyrrolidone granuloma. Am J Surg Pathol. 1984;8(5):393–8.
Fawcett HASN. Injection-site granuloma due to aluminum. Arch Dermatol. 1984;120.
Miliauskas JR, Mukherjee T, Dixon B. Postimmunization (vaccination) injection-site reactions. A report of four cases and review of the literature. Am J Surg Pathol. 1993;17(5):516–24.
Shiota M, Tokuda N, Kanou T, Yamasaki H. Incidence rate of injection-site granulomas resulting from the administration of luteinizing hormone-releasing hormone analogues for the treatment of prostatic cancer. Yonsei Med J. 2007;48(3):421–4.
Prosch H, Mirzaei S, Oschatz E, Strasser G, Huber M, Mostbeck G. Case report: gluteal injection site granulomas: false positive finding on FDG-PET in patients with non-small cell lung cancer. Br J Radiol. 2005;78(932):758–61.
Kataoka Y, Wada M, Bito M, Asai J, Katoh N. Subcutaneous nodules at progesterone injection sites after fertility treatment. Australas J Dermatol. 2019;60(2):143–4.
Li Z, Li F, Wang L. Sclerosing lipogranuloma presenting as movable masses induced by large doses of progesterone injection. J Dermatol. 2018;45(5):e114–5.
Xiao W, Huang X, Lin C, Liu Y, Chen S, Wu R. Panniculitis caused by progesterone injection can be treated by physical therapy. Dermatol Ther. 2020;3:e14501. https://doi.org/10.1111/dth.14501.
Daly CP, Jaeger B, Sill DS. Variable appearances of fat necrosis on breast MRI. AJR Am J Roentgenol. 2008;191(5):1374–80.
Chan LP, Gee R, Keogh C, Munk PL. Imaging Features of Fat Necrosis. AJR Am J Roentgenol. 2003;181(4):955–9.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
IRB information
Institutional research ethics board approval with waived consent was obtained for this retrospective study.
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
White, L.M., Senouci, S.I., Mohankumar, R. et al. Imaging features of gluteal in vitro fertilization injection granulomas, with delayed clinical presentation simulating soft tissue sarcoma. Skeletal Radiol 50, 2267–2272 (2021). https://doi.org/10.1007/s00256-021-03791-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00256-021-03791-y