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An update on imaging of Paget’s sarcoma

Skeletal Radiology volume 50, pages 1275–1290 (2021)Cite this article

Abstract

Paget’s sarcoma is a rare and particularly aggressive tumour arising within pagetic bone, affecting approximately 1% of patients with Paget’s disease during the course of their disease. Most of these tumours are osteosarcomas, but the age profile, skeletal distribution and clinical outcomes differ considerably from conventional osteosarcoma. In this review, we outline the clinical, radiographic/CT, scintigraphic and magnetic resonance imaging features of Paget’s sarcoma. We also review the neoplastic and non-neoplastic mimics of Paget’s sarcoma that should be considered in the differential diagnosis when encountering an aggressive lesion within pagetic bone.

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Acknowledgements

The authors would like to acknowledge Dr. Roberto Tirabosco for providing the histology images.

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  1. Department of Radiology, The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK

    William Tilden & Asif Saifuddin

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  1. William Tilden
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  2. Asif Saifuddin
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Correspondence to William Tilden.

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Tilden, W., Saifuddin, A. An update on imaging of Paget’s sarcoma. Skeletal Radiol 50, 1275–1290 (2021). https://doi.org/10.1007/s00256-020-03682-8

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  • DOI: https://doi.org/10.1007/s00256-020-03682-8

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