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Amyloidoma: a review and case report

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Abstract

Amyloidoma is a solitary mass of amyloid protein that arises in patients with or without evidence of systemic amyloidosis, and can be found in a variety of different organ systems. Herein, we describe three cases of localized biopsy-positive amyloidomas with no evidence of systemic involvement—primary amyloidoma. Our cases include a patient with a paraspinal soft tissue amyloidoma, a patient with multiple primary amyloidomas involving the thoracic cavity and flank, and a patient with insulin-injection induced amyloidoma of the left shoulder. We present these cases to provide further insights into the clinical presentation of this uncommon clinical entity. We review the pathophysiology of amyloidosis and discuss our cases in the context of previous reports of amyloidoma.

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Authors and Affiliations

  1. University of Miami Miller School of Medicine, 1611 NW 12th Ave, Miami, FL, 33136, USA

    Sohil S. Desai

  2. Department of Orthopedics, University of Miami / Jackson Memorial Hospital, Miami, FL, USA

    Michael G. Rizzo, Augustus J. Rush III & Motasem Al Maaieh

  3. Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA

    Andrew E. Rosenberg

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  1. Sohil S. Desai
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  2. Michael G. Rizzo
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Desai, S.S., Rizzo, M.G., Rush, A.J. et al. Amyloidoma: a review and case report. Skeletal Radiol 50, 437–444 (2021). https://doi.org/10.1007/s00256-020-03560-3

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  • DOI: https://doi.org/10.1007/s00256-020-03560-3

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