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Image-guided botulinum toxin injection in the lateral abdominal wall prior to abdominal wall reconstruction surgery: review of techniques and results

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Abstract

Ventral hernias represent the most common complication after abdominal surgery. Loss of domain and/or large ventral hernias in patients are especially challenging for surgeons to manage, but preoperative image-guided botulinum toxin injection has emerged as an effective adjunct to abdominal wall surgery. Loss of domain is caused by chronic muscle retraction of the lateral abdominal wall and leads to an irreducible protrusion of abdominal viscera into the hernia sac. Botulinum toxin can be used in the oblique muscles as a chemical component relaxation technique to aid abdominal wall reconstruction. Intramuscular botulinum toxin injection causes functional denervation by blocking neurotransmitter acetylcholine release resulting in flaccid paralysis and elongation of lateral abdominal wall muscles, increasing the rate of fascial closure during abdominal wall reconstruction, and decreasing recurrence rates. In total, 200–300 units of onabotulinumtoxinA (Botox®) or 500 units of abobotulinumtoxinA (Dypsort®) in a 2:1 dilution with normal saline is most commonly used. Botulinum toxin can be injected with ultrasonographic, EMG, or CT guidance. Injection should be performed at least 2 weeks prior to abdominal wall reconstruction, for maximal effect during surgery. At minimum, botulinum toxin should be injected into the external and internal oblique muscles at three separate sites bilaterally for a total of six injections. Although botulinum toxin use for abdominal wall reconstruction is currently not indicated by the Food and Drug Administration, it is safe with only minor complications reported in literature.

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Authors and Affiliations

  1. Division of Gastrointestinal and Minimally Invasive Surgery, Department of Surgery, Carolinas Medical Center, 1025 Morehead Medical Drive, Suite 300, Charlotte, NC, 28204, USA

    Eva B. Deerenberg, Sharbel A. Elhage, Jenny M. Shao, Vedra A. Augenstein & B. Todd Heniford

  2. Charlotte Radiology, 700 E Morehead St, Charlotte, NC, 28202, USA

    Robert J. Raible & Robert Lopez

Authors
  1. Eva B. Deerenberg
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  2. Sharbel A. Elhage
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  3. Robert J. Raible
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  4. Jenny M. Shao
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  5. Vedra A. Augenstein
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  6. B. Todd Heniford
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Corresponding author

Correspondence to Eva B. Deerenberg.

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Conflict of interest

BTH has been awarded education grants and honoraria from W.L. Gore, Allergan, and Stryker. VAA has received honoraria for speaking for Medtronic, Allergan, Intuitive, Acelity, and W.L. Gore. These involvements did not influence the interpretation of results or drafting of this manuscript. All other authors have no disclosures.

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Deerenberg, E.B., Elhage, S.A., Raible, R.J. et al. Image-guided botulinum toxin injection in the lateral abdominal wall prior to abdominal wall reconstruction surgery: review of techniques and results. Skeletal Radiol 50, 1–7 (2021). https://doi.org/10.1007/s00256-020-03533-6

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  • DOI: https://doi.org/10.1007/s00256-020-03533-6

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