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Zone- and layer-specific differences in proteoglycan content in patellofemoral pain syndrome are detectable on T1ρ MRI

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Abstract

Objective

Determine if differences in T1ρ would be detected in specific regions or layers of patellofemoral cartilage between patients with symptomatic patellofemoral pain syndrome and asymptomatic control subjects.

Materials and methods

Ten subjects diagnosed with patellofemoral pain syndrome were compared with ten age-, gender-, and BMI-matched control subjects with no knee pain or prior trauma. Conventional turbo (fast) spin echo sequences and T1ρ-weighted imaging were performed on the symptomatic knee in each of the ten subjects. At the patella and distal femur, cartilage regions of interest were divided into medial and lateral sub-regions, each then further sub-divided by layer (superficial, middle, or deep). Two-tailed t test and chi-squared tests were used to analyze demographic data. A mixed effect model was run for each sub-region of T1ρ imaging. Statistical significance was determined using the likelihood ratio test against reduced models without patellofemoral pain syndrome symptomatic status as a fixed effect.

Results

There was no difference in age, sex, or BMI between symptomatic and control patients. T1ρ values were significantly higher among patellofemoral pain syndrome patients when compared with controls in the superficial zone of the lateral patella (58.43 vs. 50.83, p = 0.03) and the middle zone of the lateral patella (52.67 vs. 43.60, p = 0.03). T1ρ was also higher in the superficial zone of the medial femur (50.94 vs. 46.70, p = 0.09) with a value approaching statistical significance.

Conclusion

We report statistically significant differences in the T1ρ value in the superficial and middle zones of the lateral patella in patients with patellofemoral pain syndrome who had no abnormalities seen on conventional MRI sequences, suggesting an alteration the macromolecular structure of the cartilage in this population.

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Acknowledgments

The authors would like to thank Dr. Hongzhe Li (Lee) , for his statistical assistance throughout the study.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Nicole Zelenski

  2. Department of Orthopaedic Surgery, University of Pennsylvania, 3737 Market Street, 6th Floor, Philadelphia, PA, 19104, USA

    David P Falk, Evan Bannister & Miltiadis Zgonis

  3. Center for Magnetic Resonance & Optical Imaging, 422 Curie Boulevard, B1 Stellar Chance Labs, Philadelphia, PA, 19104, USA

    Kevin D’Aquilla & Ravinder Reddy

  4. Center for Practice Transformation, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Donner Basement, 34000 Spruce Street, Philadelphia, PA, 19104, USA

    Arijitt Borthakur

  5. Department of Radiology, University of Pennsylvania, 3400 Civic Center Boulevard Atrium, Ground Floor, Philadelphia, PA, 19104, USA

    Bruce Kneeland

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  1. Nicole Zelenski
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Correspondence to Miltiadis Zgonis.

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All procedures performed in studies involving human subjects were in accordance with the ethical standards or institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Zelenski, N., Falk, D., D’Aquilla, K. et al. Zone- and layer-specific differences in proteoglycan content in patellofemoral pain syndrome are detectable on T1ρ MRI. Skeletal Radiol 49, 1397–1402 (2020). https://doi.org/10.1007/s00256-020-03418-8

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  • DOI: https://doi.org/10.1007/s00256-020-03418-8

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