Upper extremity myxofibrosarcoma mimicking an erosive inflammatory arthritis: a case report

  • Ceylan ColakEmail author
  • Scott E. Kilpatrick
  • Nathan W. Mesko
  • Carl S. Winalski
Case Report


Myxofibrosarcoma is a malignant fibroblastic soft tissue neoplasm containing a variable amount of myxoid stroma that commonly presents as a slow-growing mass in elderly patients. The neoplasm may be superficial or deep to the muscle fascia and characteristically has an infiltrative growth pattern with a dominant or multinodular mass. We describe an unusual case of high-grade myxofibrosarcoma of the wrist and forearm that infiltrated the muscles, tendons, and wrist joint, causing bone erosions. The tumor was mistakenly diagnosed as synovitis and a chronic, erosive, inflammatory process. The diffuse nature, absence of a dominant mass, and radiographic appearance complicated the diagnosis. Although neoplasms of the synovial spaces are rare, this case demonstrates that tumors with a highly infiltrative growth pattern can mimic inflammatory synovitis and that neoplasms should be considered in the differential diagnosis when clinical and laboratory features are discordant with the imaging appearance.


Myxofibrosarcoma Infiltrative growth pattern Synovitis 



We thank Megan Griffiths for her editorial assistance.

Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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© ISS 2019

Authors and Affiliations

  1. 1.Imaging InstituteCleveland ClinicClevelandUSA
  2. 2.Department of Anatomic PathologyCleveland ClinicClevelandUSA
  3. 3.Department of Orthopaedic SurgeryCleveland ClinicClevelandUSA
  4. 4.Department of Biomedical Engineering, Lerner Research InstituteCleveland ClinicClevelandUSA

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