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Local recurrence of soft-tissue sarcoma: issues in imaging surveillance strategy

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Abstract

Soft-tissue sarcomas pose diagnostic and therapeutic challenges to physicians, owing to the large number of subtypes, aggressive tumor biology, lack of consensus on management, and controversy surrounding interval and duration of surveillance scans. Advances in multidisciplinary management have improved the care of sarcoma patients, but controversy remains regarding strategies for surveillance following definitive local control. This review provides an updated, comprehensive overview of the current understanding of the risk of local recurrence of soft-tissue sarcoma, by examining the literature based on features such as histological type and grade, tumor size, and resection margin status, with the aim of helping clinicians, surgeons, and radiologists to develop a tailored approach to local imaging surveillance.

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Authors and Affiliations

  1. Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Avenue, JMH WW 279, Miami, FL, 33136, USA

    Nisreen S. Ezuddin & Ty K. Subhawong

  2. Department of Orthopaedic Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Juan Pretell-Mazzini

  3. Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Raphael L. Yechieli

  4. Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Darcy A. Kerr

  5. Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Breelyn A. Wilky

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  1. Nisreen S. Ezuddin
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  2. Juan Pretell-Mazzini
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  3. Raphael L. Yechieli
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  4. Darcy A. Kerr
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  5. Breelyn A. Wilky
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  6. Ty K. Subhawong
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Correspondence to Ty K. Subhawong.

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The authors declare that they have no conflicts of interest.

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The authors Nisreen S. Ezuddin, Juan Pretell-Mazzini, Raphael L. Yechieli, and Darcy Kerr have received no funding for the preparation of this manuscript. Breelyn A. Wilky is currently receiving research funding from Merck & Co., Inc. Ty K. Subhawong has received honoraria from iiCME for speaking activities unrelated to the preparation of this manuscript.

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Ezuddin, N.S., Pretell-Mazzini, J., Yechieli, R.L. et al. Local recurrence of soft-tissue sarcoma: issues in imaging surveillance strategy. Skeletal Radiol 47, 1595–1606 (2018). https://doi.org/10.1007/s00256-018-2965-x

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  • DOI: https://doi.org/10.1007/s00256-018-2965-x

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