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Melorheostosis with recurrent soft-tissue components: a histologically confirmed case

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Abstract

Melorheostosis is a very rare disorder characterized by irregular cortical thickening seen on radiographs. In this paper, we present a case of melorheostosis with microscopically confirmed soft-tissue components. The patient was a 51-year-old man who complained of severe pain in the lateral aspect of his right knee. The excision of an ossified soft-tissue lesion relieved intractable pain that had lasted 20 years. Microscopically, the cortex of the affected fibula was composed of thick compact bone and the soft-tissue component consisted of dense compact bone without endochondral ossification. The presence of soft-tissue osseous nodules around the joints is one of the specific conditions for melorheostosis and should be differentiated from synovial chondromatosis. The ossified soft-tissue lesion in our patient is to our knowledge the first reported case of the histologically confirmed soft-tissue component of melorheostosis, which differs from that of synovial chondromatosis.

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Acknowledgements

We gratefully acknowledge the help of Ms Keiko Hishiki, who created an environment conducive to research.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, 330-8503, Saitama, Japan

    Shoichi Hasegawa, Shotaro Kanda & Toru Akiyama

  2. Department of Pathology, Dokkyo Medical University Koshigaya Hospital, No. 1-50, 2-Chome, Minami-Koshigaya, Koshigaya-shi, Saitama, 343-8555, Japan

    Hiroki Imada & Takehiko Yamaguchi

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  1. Shoichi Hasegawa
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  2. Shotaro Kanda
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  3. Hiroki Imada
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  4. Takehiko Yamaguchi
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  5. Toru Akiyama
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Corresponding author

Correspondence to Toru Akiyama.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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This research was not sponsored by any organization.

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The authors declare that they have no conflicts of interest.

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Hasegawa, S., Kanda, S., Imada, H. et al. Melorheostosis with recurrent soft-tissue components: a histologically confirmed case. Skeletal Radiol 46, 399–404 (2017). https://doi.org/10.1007/s00256-016-2562-9

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  • DOI: https://doi.org/10.1007/s00256-016-2562-9

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