Skip to main content

Advertisement

Log in

Leprosy with ulnar nerve abscess: ultrasound findings in a child

  • Case Report
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

We report the ultrasound findings of a typical case of nerve abscess due to leprosy in an 11-year-old boy. The patient had previously undergone pediatric multibacillary leprosy multidrug therapy (MDT) in accordance with World Health Organization guidelines. He presented to our service with bilateral ulnar neuritis with no response to prednisone (1 mg/kg). Right ulnar nerve ultrasound revealed nerve hypoechogenicity, fascicular pattern disorganization, marked fusiform thickening, and a round anechoic area suggestive of intraneural abscess. Intense intraneural power Doppler signal was detected, indicating active neuritis. Intravenous methylprednisolone had a poor response and the patient was submitted to ulnar nerve decompression, which confirmed nerve abscess with purulent discharge during surgery. As the patient weighed more than 40 kg, treatment with a pediatric dose was considered insufficient and adult-dose MDT was prescribed, with improvement of nerve pain and function. Although leprosy is rare in developed countries, it still exists in the USA and it is endemic in many developing countries. Leprosy neuropathy is responsible for the most serious complications of the disease, which can lead to irreversible impairments and deformities. Nerve abscess is an uncommon complication of leprosy and ultrasound can efficiently demonstrate this condition, allowing for prompt treatment. There is scant literature about the imaging findings of nerve abscess in leprosy patients. Radiologists should suspect leprosy in patients with no other known causes of neuropathy when detecting asymmetric nerve enlargement and nerve abscess on ultrasound.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Nolen L, Haberling D, Scollard D, Truman R, Rodriguez-Lainz A, Blum L, et al. Incidence of Hansen’s Disease—United States, 1994–2011. MMWR Morb Mortal Wkly Rep. 2014;63(43):970–2.

    Google Scholar 

  2. Martinoli C, Derchi LE, Bertolotto M, Gandolfo N, Bianchi S, Fiallo P, et al. US and MR imaging of peripheral nerves in leprosy. Skeletal Radiol. 2000;29(3):142–50.

    Article  CAS  PubMed  Google Scholar 

  3. Elias J, Nogueira-Barbosa MH, Feltrin LT, Furini RB, Foss NT, Marques-Jr W. Role of ulnar nerve sonography in leprosy neuropathy with electrophysiologic correlation. J Ultrasound Med. 2009;28:1201–9.

    PubMed  Google Scholar 

  4. Jain S, Visser LH, Praveen TLN, Rao PN, Surekha T, Ellanti R, et al. High-resolution sonography: a new technique to detect nerve damage in leprosy. PLoS Negl Trop Dis. 2009;3(8):e498. doi:10.1371/journal.pntd.0000498.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Frade MAC, Nogueira-Barbosa MH, Lugão HB, Furini RB, Júnior WM, Foss NT. New sonographic measures of peripheral nerves: a tool for the diagnosis of peripheral nerve involvement in leprosy. Mem Inst Oswaldo Cruz. 2013;108(3):257–62.

    Article  PubMed Central  Google Scholar 

  6. Lugão HB, Nogueira-Barbosa MH, Marques-Jr W, Foss NT, Frade MAC. Asymmetric nerve enlargement: a characteristic of leprosy neuropathy demonstrated by ultrasonography. PLoS Negl Trop Dis. 2015;9(12):e0004276. doi:10.1371/journal.pntd.0004276.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Rai D, Malhotra HS, Garg RK, Goel MM, Malhotra KP, Kumar V, et al. Nerve abscess in primary neuritic leprosy. Lepr Rev. 2013;84(2):136–40.

    PubMed  Google Scholar 

  8. Sen D, Satija L, Chatterji S, Majumder A, Gupta A, Kumar A. Ultrasonography and magnetic resonance imaging of ulnar nerve abscess in leprosy. Med J Armed Forces India. 2013;72(1):78–81.

    Article  PubMed  Google Scholar 

  9. Mendiratta V, Khan A, Jain A. Primary neuritic leprosy: a reappraisal at a tertiary care hospital. Indian J Lepr. 2006;78:261–7.

    CAS  PubMed  Google Scholar 

  10. Hari S, Subramanian S, Sharma R. Magnetic resonance imaging of ulnar nerve abscess in leprosy: a case report. Lepr Rev. 2007;78(2):155–9.

    PubMed  Google Scholar 

  11. Slim FJ, Faber WR, Maas M. The role of radiology in nerve function impairment and its musculoskeletal complications in leprosy. Lepr Rev. 2009;80:373–87.

    PubMed  Google Scholar 

  12. WHO. Wkly Epidemiol Rec. Global leprosy update, 2014: need for early case detection. 2015;90(36):461–76.

    Google Scholar 

  13. Lockwood DNJ, Saunderson PR. Nerve damage in leprosy: a continuing challenge to scientists, clinicians and service providers. Int Health R Soc Trop Med Hyg. 2012;4(2):77–85.

    Google Scholar 

  14. Lancet Neurology. Leprosy as a neurological disease. Lancet Neurol. 2009; 8(3):217. doi:10.1016/S1474-4422(09)70026-2.

  15. Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255–73.

    CAS  PubMed  Google Scholar 

  16. Ooi WW, Srinivasan J. Leprosy and the peripheral nervous system: basic and clinical aspects. Muscle Nerve. 2004;30(4):393–409.

    Article  PubMed  Google Scholar 

  17. Salafia A, Chauhan G. Nerve abscess in children and adults leprosy patients: analysis of 145 cases and review of the literature. Acta Leprol. 1996;10(1):45–50.

    CAS  PubMed  Google Scholar 

  18. Zaidman CM, Seelig MJ, Baker JC, Mackinnon SE, Pestronk A. Detection of peripheral nerve pathology: comparison of ultrasound and MRI. Neurology. 2013;80(18):1634–40.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Ward RJ, Zawodniak LJ, Blake MA, Eustace SJ. Musculoskeletal case of the day: tuberculoid leprosy. AJR Am J Roentgenol. 1999;173:803.

    Article  Google Scholar 

  20. Osmanovic S, Al-Heeti OM, Lin AY, Zivin SP, Justo JA, Mayer SM, et al. Staphylococcus aureus infection of the optic nerve. J Neuroophthalmol. 2015;35(1):48–50.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Chaganti J, Marriott D, Steel T, Donovan J, Biggs N. Perineural trigeminal nerve abscess secondary to mucor sinusitis: serial diffusion-weighted MRI and literature review. Clin Radiol. 2011;66(11):1106–9.

    Article  CAS  PubMed  Google Scholar 

  22. Ishii K, Ishii N, Nakanaga K, Nakano K, Saito I, Asahina A. Mycobacterium haemophilum infection with prominent facial manifestation mimicking leprosy. J Dermatol. 2015;42(10):992–5.

    Article  PubMed  Google Scholar 

  23. Ramanujam K. Solitary neurofibroma mimicking nerve abscess. Indian J Lepr. 1993;65(3):337–9.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Helena Barbosa Lugão.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflicts of interest.

Informed consent

Informed consent was obtained from the legal party responsible for the participant included in this study. The Institutional Review Board approved the publication of this case report.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lugão, H.B., Frade, M.A.C., Mazzer, N. et al. Leprosy with ulnar nerve abscess: ultrasound findings in a child. Skeletal Radiol 46, 137–140 (2017). https://doi.org/10.1007/s00256-016-2517-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-016-2517-1

Keywords

Navigation