Abstract
Diffuse infiltrative neurofibroma is a rare clinical entity that can pose a diagnostic challenge not only due to its rarity but also due to its varied clinical, radiological, and histological features. Our case illustrates how this entity may be misdiagnosed on clinical and pathological examination. Radiological imaging plays a critical and collaborative role in guiding clinicians and pathologists when faced with this challenging diagnosis.
References
Kransdorf MJ. Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR Am J Roentgenol. 1995;164(2):395–402.
Kransdorf, Murphey et al. Imaging of soft tissue tumors. Lippincott. 2006.
Peh WC, Shek TW, Yip DK. Magnetic resonance imaging of subcutaneous diffuse neurofibroma. Br J Radiol. 1997;70(839):1180–3.
Hassell DS, Bancroft LW, Kransdorf MJ, et al. Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol. 2008;190(3):582–8.
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. WHO Classification of Tumours of Soft Tissue and Bone. Pathology and Genetics of Tumours of Soft Tissue and Bone. 4th ed. Lyon: IARC Press; 2013.
Folpe AL, Inwards CY. Bone and Soft Tissue Pathology. Elsevier Health Sciences; 2010.
Lim R, Jaramillo D, Poussaint TY, Chang Y, Korf B. Superficial neurofibroma: a lesion with unique MRI characteristics in patients with neurofibromatosis type 1. AJR Am J Roentgenol. 2005;184(3):962–8.
O’Keefe P, Reid J, Morrison S, Vidimos A, Difiore J. Unexpected diagnosis of superficial neurofibroma in a lesion with imaging features of a vascular malformation. Pediatr Radiol. 2005;35(12):1250–3.
Enzinger FM, Weiss SW. Soft tissue tumors. 3rd ed. New York: Mosby; 1995. p. 889–928.
Ergün SS, Emel E, Karabekir S, Büyükbabani N. Extracranial diffuse neurofibroma with intracranial extension. Plast Reconstr Surg. 2000;105(2):801–3.
Trăistaru R, Rogoveanu O, Popescu R, Enăchescu V, Ghiluşi M. Periarticular diffuse neurofibroma of the upper limb. Rom J Morphol Embryol. 2011;52(4):1377–83.
Evans HL. Sporadic superficial diffuse neurofibromas with repeated local recurrence over many years and a tendency toward malignant change a report of 3 cases. Am J Surg Pathol 2013.
Huang GS, Huang CW, Lee HS, et al. On the AJR viewbox. Diffuse neurofibroma of the arm: MR characteristics. AJR Am J Roentgenol. 2005;184(5):1711–2.
Chen W, Jia JW, Wang JR. Soft tissue diffuse neurofibromas: sonographic findings. J Ultrasound Med. 2007;26(4):513–8.
Macias VC, Rafael M, Fernandes C, Rosa JC. Diffuse neurofibroma–an uncommon cause of alopecia. An Bras Dermatol. 2013;88(6 Suppl 1):166–9.
Beggs I, Gilmour HM, Davie RM. Diffuse neurofibroma of the ankle. Clin Radiol. 1998;53(10):755–9.
Bhattacharyya AK, Perrin R, Guha A. Peripheral nerve tumors: management strategies and molecular insights. J Neurooncol. 2004;69(1–3):335–49.
Lee HJ, Im JG, Goo JM, et al. Peripheral T-cell lymphoma: spectrum of imaging findings with clinical and pathologic features. Radiographics. 2003;23(1):7–26.
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Ravi, A.K., Ram, R., Lindberg, M.R. et al. Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum. Skeletal Radiol 43, 1773–1778 (2014). https://doi.org/10.1007/s00256-014-1965-8
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DOI: https://doi.org/10.1007/s00256-014-1965-8