Skip to main content
SpringerLink
Log in

Measurement of vertebral bone marrow lipid profile at 1.5-T proton magnetic resonance spectroscopy and bone mineral density at dual-energy X-ray absorptiometry: correlation in a swine model

  • Technical Report
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

References

  1. Rosen BR, Fleming DM, Kushner DC, et al. Hematologic bone marrow disorders: quantitative chemical shift MR imaging. Radiology. 1988;169:799–804.

    CAS  PubMed  Google Scholar 

  2. Schellinger D, Lin CS, Fertikh D, et al. Normal lumbar vertebrae: anatomic, age and sex variance in subjects at proton MR spectroscopy—initial experience. Radiology. 2000;215:910–6.

    Article  CAS  PubMed  Google Scholar 

  3. Rosen CJ, Ackert-Bicknell C, Rodriguez JP, et al. Marrow fat and the bone microenvironment: developmental, functional and pathological implications. Crit Rev Eukaryot Gene Expr. 2009;19:109–24.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Yeung DK, Griffith JF, Antonio GE, et al. Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging. 2005;22:279–85.

    Article  PubMed  Google Scholar 

  5. Baum T, Yap SP, Karampinos DC, et al. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magn Reson Imaging. 2012;35:117–24.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Dunnill MS, Anderson JA, Whitehead R. Quantitative histological studies on age changes in bone. J Pathol Bacteriol. 1967;94:275–91.

    Article  CAS  PubMed  Google Scholar 

  7. Akune T, Ohba S, Kamekura S, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113:846–55.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Drost DJ, Riddle WR, Clarke GD, et al. Proton magnetic resonance spectroscopy in the brain: report of AAPM MR Task Group #9. Med Phys. 2002;29:2177–97.

    Article  CAS  PubMed  Google Scholar 

  9. Naressi A, Couturier C, Devos JM, et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA. 2001;12:141–52.

    Article  CAS  PubMed  Google Scholar 

  10. Lunney JK. Advances in swine biomedical model genomics. Int J Biol Sci. 2007;3:179–84.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Litten-Brown JC, Corson AM, Clarke L. Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview. Animal. 2010;4:899–920.

    Article  CAS  PubMed  Google Scholar 

  12. Aerssens J, Boonen S, Lowet G, et al. Interspecies differences in bone composition, density, and quality: potential implications for in vivo bone research. Endocrinology. 1998;139:663–70.

    CAS  PubMed  Google Scholar 

  13. Heino TJ, Alm JJ, Moritz N, et al. Comparison of the osteogenic capacity of minipig and human bone marrow-derived mesenchymal stem cells. J Orthop Res. 2012;30:1019–25.

    Article  PubMed  Google Scholar 

  14. Schellinger D, Lin CS, Hatipoglu HG, Fertikh D. Potential value of vertebral proton MR spectroscopy in determining bone weakness. Am J Neuroradiol. 2001;22:1620–7.

    CAS  PubMed  Google Scholar 

  15. Griffith JF, Yeung DK, Antonio GE, et al. Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation. Radiology. 2006;241:831–8.

    Article  PubMed  Google Scholar 

  16. Kugel H, Jung C, Schulte O, Heindel W. Age- and sex- specific differences in the 1H-spectrum of vertebral bone marrow. J Magn Reson Imaging. 2001;13:263–8.

    Article  CAS  PubMed  Google Scholar 

  17. Mulkern RV, Meng J, Bowers JL, et al. In vivo bone marrow lipid characterization with line scan Carr-Purcell-Meiboom-Gill proton spectroscopic imaging. Magn Reson Imaging. 1997;15:823–37.

    Article  CAS  PubMed  Google Scholar 

  18. Rico-Sanz J, Thomas EL, Jenkinson G, et al. Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS. J Appl Physiol. 1999;87:2068–72.

    CAS  PubMed  Google Scholar 

  19. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that there are no conflicts of interest to report.

Author information

Authors and Affiliations

  1. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan, 20097, San Donato Milanese, Italy

    Giovanni Di Leo, Laura Fina & Francesco Sardanelli

  2. Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, via Festa del Perdono 7, 20122, Milan, Italy

    Michele Bandirali & Carmelo Messina

  3. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Piazza E. Malan, 20097, San Donato Milanese, Italy

    Francesco Sardanelli

Authors
  1. Giovanni Di Leo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michele Bandirali
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laura Fina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Carmelo Messina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Francesco Sardanelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michele Bandirali.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Di Leo, G., Bandirali, M., Fina, L. et al. Measurement of vertebral bone marrow lipid profile at 1.5-T proton magnetic resonance spectroscopy and bone mineral density at dual-energy X-ray absorptiometry: correlation in a swine model. Skeletal Radiol 43, 1123–1128 (2014). https://doi.org/10.1007/s00256-014-1833-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-014-1833-6

Keywords

Search

Navigation