Skip to main content

Intramuscular Castleman’s disease of the deltoid: a case report and review of the literature


Castleman’s disease (CD), a rare benign disease characterized by lymphoid hyperplasia, typically arises in the mediastinum as a solitary tumor. We describe herein a rare case of intramuscular CD occurring in the left deltoid in a 28-year-old woman. The present case is instructive in the differential diagnosis of primary soft tissue tumors, for which the possibility of CD should be considered.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2


  1. Castleman B, Towne VW. Case records of the Massachusetts General Hospital: case no. 40231. N Engl J Med. 1954;250:1001–5.

    CAS  PubMed  Article  Google Scholar 

  2. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956;9:822–30.

    Article  CAS  PubMed  Google Scholar 

  3. Waterston A, Bower M. Fifty years of multicentric Castleman's disease. Acta Oncol. 2004;43:698–704.

    Article  PubMed  Google Scholar 

  4. Casper C. The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol. 2005;129:3–17.

    Article  PubMed  Google Scholar 

  5. Cohen H. Tumor-like proliferations of lymphoid tissue; occurrence in deltoid muscle and mediastinum. J Mt Sinai Hosp N Y. 1957;24:750–60.

    CAS  PubMed  Google Scholar 

  6. Zettergren L. Probably neoplastic proliferation of lymphoid tissue (follicular lympho-reticuloma). Reports of four cases with a survey of literature. Acta Pathol Microbiol Scand. 1961;51:113–26.

    CAS  PubMed  Google Scholar 

  7. Lattes R, Pachter MR. Benign lymphoid masses of probable hamartomatous nature. Analysis of 12 cases. Cancer. 1962;15:197–214.

    Article  CAS  PubMed  Google Scholar 

  8. Abell MR. Lymphoid hamartoma. Radiol Clin North Am. 1968;6:15–24.

    CAS  PubMed  Google Scholar 

  9. Rooney RC, Pitcher JD. Castleman's disease in the extremity. Am J Orthop. 1998;27:373–4.

    CAS  PubMed  Google Scholar 

  10. Williams HR, Millner PA, Coral A. Castleman's disease of the erector spinae muscle. Skeletal Radiol. 1998;27:637–40.

    Article  CAS  PubMed  Google Scholar 

  11. Fiel-Gan MD, Voytek TM, Weiss RG, Brown RT, Joshi VV. Castleman's disease of the left triceps in a child suspected to be a small round cell tumor of childhood. Pediatr Dev Pathol. 2000;3:286–9.

    Article  CAS  PubMed  Google Scholar 

  12. Kazakov DV, Fanburg-Smith JC, Suster S, et al. Castleman disease of the subcutis and underlying skeletal muscle: report of 6 cases. Am J Surg Pathol. 2004;28:569–77.

    PubMed  Google Scholar 

  13. Isaacson PG, Campo E, Harris NL. Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer; 2008. p. 258–9.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michiyuki Hakozaki.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hakozaki, M., Tajino, T., Yamada, H. et al. Intramuscular Castleman’s disease of the deltoid: a case report and review of the literature. Skeletal Radiol 39, 715–719 (2010).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • Castleman’s disease
  • Soft tissue tumor
  • Deltoid
  • Intramuscular tumor
  • Malignant lymphoma