Skip to main content
SpringerLink
Log in

Perspective: cartilage toxicity from local anesthetics

  • Perspective
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Mather LE, Chang DHT. Cardiotoxicity with modern local anesthestics: is there a safer choice. Drugs 2001; 61: 333–342.

    Article  PubMed  CAS  Google Scholar 

  2. Knudsen K, Beckman Suurkula M, Blomberg S, Sjovall J, Edvardsson N. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth. 1997; 78: 507–514.

    PubMed  CAS  Google Scholar 

  3. Boren E, Teuber SS, Naguwa SM, Gershwin ME. A critical review of local anesthetic sensitivity. Clin Rev Allergy Immunol. 2007; 32(1): 119–128.

    PubMed  CAS  Google Scholar 

  4. Sullivan SG, Abbott PJ. Cardiovascular toxicity associated with intraarticular bupivacaine. Anesth Analg 1994; 79: 591–593.

    Article  PubMed  CAS  Google Scholar 

  5. Katz JA, Kaeding CS, Hill JR, Henthorn TK. The pharmacokinetics of bupivacaine when injected intra-articularly after knee arthroscopy. Anesth Analg. 1988; 67(9): 872–875.

    Article  PubMed  CAS  Google Scholar 

  6. Convery PN, Milligan KR, Quinn P, Sjövall J, Gustafsson U. Efficacy and uptake of ropivacaine and bupivacaine after single intra-articular injection in the knee joint. Br J Anaesth. 2001; 87(4): 570–576.

    Article  PubMed  CAS  Google Scholar 

  7. Dogan N, Erdem AF, Erman Z, Kizilkaya M. The effects of bupivacaine and neostigmine on articular cartilage and synovium in the rabbit knee joint. J Int Med Res. 2004; 32(5): 513–519.

    PubMed  CAS  Google Scholar 

  8. Chu CR, Izzo NJ, Papas NE, Fu FH. In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes. Arthroscopy 2006; 22(7): 693–699.

    PubMed  Google Scholar 

  9. Karpie JC, Chu CR. Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro. Am J Sports Med. 2007; 35(10): 1621–1627.

    Article  PubMed  Google Scholar 

  10. Chu CR, Izzo NJ, Coyle CH, Papas NE, Logar A. The in vitro effects of bupivacaine on articular chondrocytes. J Bone Joint Surg Br. 2008; 90(6): 814–820.

    Article  PubMed  CAS  Google Scholar 

  11. Piper SL, Kim HT. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Br. 2008; 90-A: 986–991.

    Article  Google Scholar 

  12. Sanders TG, Zlatkin MB, Paruchuri BN, Higgins RW. Chondrolysis of the glenohumeral joint after arthroscopy: findings on radiography and low-field-strength MRI. AJR Am J Roentgenol 2007; 188: 1094–1098.

    Article  PubMed  Google Scholar 

  13. Petty DH, Jazrawi LM, Estrada LS, Andrews JR. Glenohumeral chondrolysis after shoulder arthroscopy: case reports and review of the literature. Am J Sports Med 2004; 32: 509–515.

    Article  PubMed  Google Scholar 

  14. Hansen BP, Beck CL, Beck EP, Townsley RW. Postarthroscopic glenohumeral chondrolysis. Am J Sports Med 2007; 35: 1628–1634.

    Article  PubMed  Google Scholar 

  15. Bojescul JA, Wilson G, Taylor DC. Idiopathic chondrolysis of the ankle. Arthroscopy: The Journal of Arthroscopic and Related Surgery 2005; 21: 224–227.

    Article  Google Scholar 

  16. Gomoll AH, Kang RW, Williams JM, Bach BR, Cole BJ. Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy 2006; 22: 813–819.

    PubMed  Google Scholar 

  17. Feinstein DL, Murphy P, Sharp A, Galea E, Gavrilyuk V, Weinberg G. Local anesthetics potentiate nitric oxide synthase type 2 expression in rat glial cells. J Neurosurg Anesthesiol 2001; 13: 99–105.

    Article  PubMed  CAS  Google Scholar 

  18. Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CN. Anesthetics impact the resolution of inflammation. PLoS ONE 2008; 3(4): e1879.

    Article  PubMed  CAS  Google Scholar 

  19. Hollmann MW, Gross A, Jelacin N, Durieux ME. Local anesthetic effects on priming and activation of human neutrophils. Anesthesiology 2001; 95: 113–122.

    Article  PubMed  CAS  Google Scholar 

  20. Park CJ, Park SA, Yoon TG, et al. Bupivacaine induces apoptosis via ROS in the Schwann cell line. J Dent Res 2005; 84: 852–857.

    Article  PubMed  CAS  Google Scholar 

  21. Scott DB, Lee A, Fagan D, Bowler GM, Bloomfield P, Lundh R. Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 1989; 69: 563–569.

    PubMed  CAS  Google Scholar 

  22. Marret E, Gentili M, Bonnet MP, Bonnet F. Intra-articular ropivacaine 0.75% and bupivacaine 0.50% for analgesia after arthroscopic knee surgery: a randomized prospective study. Arthroscopy 2005; 21(3): 313–316.

    Article  PubMed  Google Scholar 

  23. Samoladas EP, Chalidis B, Fotiadis H, Terzidis I, Ntobas T, Koimtzis M. The intra-articular use of ropivacaine for the control of post knee arthroscopy pain. J Orthop Surg 2006; 1: 17.

    Article  PubMed  Google Scholar 

  24. Martinsson T, Haegerstrand A, Dalsgaard CJ. Effects of ropivacaine on eicosanoid release from human granulocytes and endothelial cells in vitro. Inflamm Res 1997; 46: 398–403.

    Article  PubMed  CAS  Google Scholar 

  25. Blumenthal S, Borgeat A, Pasch T, Reyes L, Booy C, Lambert M, Schimmer RC, Beck-Schimmer B. Ropivacaine decreases inflammation in experimental endotoxin-induced lung injury. Anesthesiology 2006; 104(5): 961–969.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

The authors wish to thank Dr. Peter L. Munk, University of British Columbia, for bringing this issue to our attention.

Author information

Authors and Affiliations

  1. Department of Radiology, Massachusetts General Hospital, Boston, MA, 02115, USA

    Ravi Kamath

  2. Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 02115, USA

    Gary Strichartz

  3. Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, 02115, USA

    Daniel Rosenthal

Authors
  1. Ravi Kamath
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gary Strichartz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniel Rosenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ravi Kamath.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kamath, R., Strichartz, G. & Rosenthal, D. Perspective: cartilage toxicity from local anesthetics. Skeletal Radiol 37, 871–873 (2008). https://doi.org/10.1007/s00256-008-0567-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-008-0567-8

Keywords

Search

Navigation