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Relationships between plain-film radiographic patterns and clinicopathologic variables in AJCC stage II osteosarcoma

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Abstract

Objective

In this retrospective study, we assessed the plain-film radiographic patterns of American Joint Committee on Cancer (AJCC) stage II osteosarcoma and analyzed the relationship between these patterns and clinicopathologic variables.

Materials and methods

We retrospectively reviewed 347 patients with AJCC stage II osteosarcoma who were treated at our institute. Patients were divided into three groups based on radiographic patterns, i.e., osteoblastic, osteolytic, and mixed. Fisher’s exact chi-square test was performed to analyze correlations between radiographic patterns and clinicopathological variables.

Results

One hundred and eighty-eight patients had an osteoblastic tumor, 101 had an osteolytic tumor, and 58 had a mixed tumor. Tumors with an osteoblastic pattern showed a tendency to have the following characteristics: AJCC stage II-B, osteoblastic or chondroblastic subtype, and no pathologic fracture. Conversely, osteolytic tumors were frequently of AJCC stage II-A, had a fibroblastic or rare subtype, and were associated with a pathologic fracture. Finally, mixed tumors were frequently found in men. No survival difference was found according to radiographic pattern.

Conclusions

Plain-film radiographic patterns were found to be related with clinicopathological features. We believe that it could be used to provide valuable information for treatment decision-making in cases of high-grade extremity osteosarcoma.

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Authors and Affiliations

  1. Department of Pathology, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea

    Min Suk Kim & Jae-Soo Koh

  2. Department of Radiology, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea

    Ji Young Yoo

  3. Department of Pediatrics, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea

    Jun Ah Lee

  4. Department of Orthopedic Surgery, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea

    Soo-Yong Lee, Wan Hyeong Cho, Won Seok Song & Dae-Geun Jeon

  5. Department of Orthopedic Surgery, Chonnam National University Medical School, Gwangju, Korea

    Sung Taek Jung

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  1. Min Suk Kim
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  2. Soo-Yong Lee
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  3. Wan Hyeong Cho
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  4. Won Seok Song
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  5. Jae-Soo Koh
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  6. Jun Ah Lee
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  7. Ji Young Yoo
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  8. Sung Taek Jung
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  9. Dae-Geun Jeon
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Correspondence to Dae-Geun Jeon.

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Kim, M.S., Lee, SY., Cho, W.H. et al. Relationships between plain-film radiographic patterns and clinicopathologic variables in AJCC stage II osteosarcoma. Skeletal Radiol 37, 997–1001 (2008). https://doi.org/10.1007/s00256-008-0536-2

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  • DOI: https://doi.org/10.1007/s00256-008-0536-2

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