Abstract
Objective
The purpose of this article is to describe the image findings of distant metastases to skeletal muscle with clinical correlation.
Design and patients
The records of nine consecutive patients with biopsy-proven metastases to skeletal muscle from primary malignancies were retrospectively reviewed for clinical history and findings from magnetic resonance imaging (MRI) (eight cases) or computed tomography (CT) (one case). Clinical history, interval between detection of primary tumor and metastases, multiplicity, primary cell type of malignancy, site of metastases, and nature of masses on MRI or CT were evaluated by two musculoskeletal radiologists.
Results
The most common symptom was a painful mass (78%), and the most common site was the thigh (78%). Four patients showed a single mass (44%). There was previous malignancy in five patients (56%), but four patients had no prior malignancy (44%). The time interval between the detection of primary malignancy and metastases was 8 months to 15 years. Mean size of metastases was 5.1 ± 2.2 cm. The most common primary tumor was of the lung (two patients) and kidney (two patients), and the most common cell type was adenocarcinoma. On images, necrosis and peritumoral edema were relatively frequent. All cases showed good enhancement. of contrast medium.
Conclusion
Skeletal muscle metastases show good enhancement of contrast medium and frequent edema and necrosis. The possibility of skeletal muscle metastases should be borne in mind for patients with painful and multiple muscle masses.
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References
Williams JB, Youngberg RA, Bui-Mansfield LT, Pitcher JD. MR imaging of skeletal muscle metastases. AJR Am J Roentgenol 1997; 168: 555–557.
Pretorius ES, Fishman EK. Helical CT of skeletal muscle metastases from primary carcinomas. AJR Am J Roentgenol 2000; 174: 401–404.
Schultz SR, Bree RL, Schwab RE, Raiss G. CT detection of skeletal muscle metastases. J Comput Tomogr 1986; 10: 81–83.
Glockner J, White L, Sundaram M, McDonald DJ. Unsuspected metastases presenting as solitary soft tissue lesions: a fourteen-year review. Skeletal Radiol 2000; 29: 270–274.
Magee T, Rosenthal H. Skeletal muscle metastases at sites of documented trauma. AJR Am J Roentgenol 2002; 178: 958–988.
Glockner J, Sundaram M, White L. Incidence of solitary soft-tissue metastases revealed by MR imaging. AJR Am J Roentgenol 2002; 179: 1644.
Garcia OA, Fernandez EG, Satué EG, Buelta SL, Val-Bernal JF. Metastasis of malignant neoplasm to skeletal muscle. Rev Esp Oncol 1984; 31: 57–67.
Pearson CM. Incidence and type of pathologic alternations observed in muscle in a routine autopsy survey. Neurology 1959; 9: 757–766.
Pickren JW. Use and limitations of autopsy data. In: Weiss L, editor. Fundamental aspects of metastasis. Amsterdam: North-Holland; 1976. p. 377–384.
Sridhar KS, Rao RK, Kunhardt B. Skeletal muscle metastases from lung cancer. Cancer 1987; 59: 1530–1534.
Suto Y, Yamaguchi Y, Sugihara S. Skeletal muscle metastases from lung carcinoma: MR findings. J Comput Tomogr 1997; 21: 304–305.
Herring CL Jr, Harrelson JM, Scully SP. Metastatic carcinoma to skeletal muscle. A report of 15 patients. Clin Orthop Relat Res 1998; 355: 272–281.
Plaza JA, Perez-Montiel D, Mayerson J, Morrison C, Suster S. Metastases to soft tissue: a review of 118 cases over a 30-year period. Cancer 2008; 112: 193–203.
Tuoheti Y, Okada K, Osanai T, et al. Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases. Jpn J Clin Oncol. 2004; 34: 210–214.
Damron TA, Heiner J. Distant soft tissue metastases: a series of 30 new patients and 91 cases from the literature. Ann Surg Oncol. 2000; 7: 526–534.
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Lee, B.Y., Choi, J.E., Park, J.M. et al. Various image findings of skeletal muscle metastases with clinical correlation. Skeletal Radiol 37, 923–928 (2008). https://doi.org/10.1007/s00256-008-0510-z
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DOI: https://doi.org/10.1007/s00256-008-0510-z