High-resolution morphological and biochemical imaging of articular cartilage of the ankle joint at 3.0 T using a new dedicated phased array coil: in vivo reproducibility study
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The objective of this study was to evaluate the feasibility and reproducibility of high-resolution magnetic resonance imaging (MRI) and quantitative T2 mapping of the talocrural cartilage within a clinically applicable scan time using a new dedicated ankle coil and high-field MRI.
Materials and methods
Ten healthy volunteers (mean age 32.4 years) underwent MRI of the ankle. As morphological sequences, proton density fat-suppressed turbo spin echo (PD-FS-TSE), as a reference, was compared with 3D true fast imaging with steady-state precession (TrueFISP). Furthermore, biochemical quantitative T2 imaging was prepared using a multi-echo spin-echo T2 approach. Data analysis was performed three times each by three different observers on sagittal slices, planned on the isotropic 3D-TrueFISP; as a morphological parameter, cartilage thickness was assessed and for T2 relaxation times, region-of-interest (ROI) evaluation was done. Reproducibility was determined as a coefficient of variation (CV) for each volunteer; averaged as root mean square (RMSA) given as a percentage; statistical evaluation was done using analysis of variance.
Cartilage thickness of the talocrural joint showed significantly higher values for the 3D-TrueFISP (ranging from 1.07 to 1.14 mm) compared with the PD-FS-TSE (ranging from 0.74 to 0.99 mm); however, both morphological sequences showed comparable good results with RMSA of 7.1 to 8.5%. Regarding quantitative T2 mapping, measurements showed T2 relaxation times of about 54 ms with an excellent reproducibility (RMSA) ranging from 3.2 to 4.7%.
In our study the assessment of cartilage thickness and T2 relaxation times could be performed with high reproducibility in a clinically realizable scan time, demonstrating new possibilities for further investigations into patient groups.
KeywordsMRI Cartilage Ankle 3 T TrueFISP T2 mapping
- 3.Ba-Ssalamah A, Schibany N, Puig S, Herneth AM, Noebauer-Huhmann IM, Trattnig S. Imaging articular cartilage defects in the ankle joint with 3D fat-suppressed echo planar imaging: comparison with conventional 3D fat-suppressed gradient echo imaging. J Magn Reson Imaging 2002; 16: 209–216.PubMedCrossRefGoogle Scholar
- 16.Friedrich KM, Reiter G, Kaiser B, et al. Cartilage imaging: fundamental evaluation of modern high-resolution isotropic 3D MR sequences at 3 T. Eur Radiol 2007; 17.Google Scholar
- 17.Weckbach S, Mendlik T, Horger W, Wagner S, Reiser MF, Glaser C. Quantitative assessment of patellar cartilage volume and thickness at 3.0 tesla comparing a 3D-fast low angle shot versus a 3D-true fast imaging with steady-state precession sequence for reproducibility. Invest Radiol 2006; 41: 189–197.PubMedCrossRefGoogle Scholar
- 23.Williams A, Gillis A, McKenzie C, et al. Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications. Am J Roentgenol 2004; 182: 167–172.Google Scholar
- 38.Kurkijarvi JE, Nissi MJ, Ojala RO, et al. In vivo T2 mapping and dGEMRIC of human articular cartilage repair after autologous chondrocyte transplantation. Proc Intl Soc Magn Reson Med 2005; 13: 481.Google Scholar
- 46.Welsch GH, Mamisch TC, Salomonowitz E, et al. Quantitative T2 mapping of matrix-associated autologous chondrocyte transplantation: an in vivo follow-up study. Eur Radiol 2007; 17: 291.Google Scholar