Skeletal Radiology

, Volume 36, Issue 12, pp 1121–1127 | Cite as

A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid

  • Carlo C. QuattrocchiEmail author
  • Daniele Santini
  • Paola Dell’Aia
  • Sara Piciucchi
  • Emanuele Leoncini
  • Bruno Vincenzi
  • Rosario Francesco Grasso
  • Giuseppe Tonini
  • Bruno Beomonte Zobel
Scientific Article



The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months.

Patients and methods

Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density.


The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone.


Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone.


Bone metastases Computed tomography Zoledronic acid 


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Copyright information

© ISS 2007

Authors and Affiliations

  • Carlo C. Quattrocchi
    • 1
    Email author
  • Daniele Santini
    • 2
  • Paola Dell’Aia
    • 1
  • Sara Piciucchi
    • 1
  • Emanuele Leoncini
    • 3
  • Bruno Vincenzi
    • 2
  • Rosario Francesco Grasso
    • 1
  • Giuseppe Tonini
    • 2
  • Bruno Beomonte Zobel
    • 1
  1. 1.Department of RadiologyCentro Interdisciplinare per la Ricerca Bio-MedicaRomeItaly
  2. 2.Department of OncologyUniversity Campus Bio-Medico di RomaRomeItaly
  3. 3.Statistica Sanitaria, University La SapienzaRomeItaly

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