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Skeletal Radiology

, Volume 36, Issue 12, pp 1105–1107 | Cite as

Bone graft substitutes

  • T. W. Bauer
Perspective

Surgeons involved in skeletal repair, reconstruction, and oncology commonly encounter or create bone defects that are unlikely to heal if treated by fixation alone. Cancellous and cortical autografts have been used for decades to treat skeletal defects, but the amount of autograft is limited, and morbidity related to autograft harvesting can be considerable. Allograft can “extend” autograft, but has limited biological and mechanical properties, carries with it the potential for disease transmission, and has not been accepted for other reasons in some societies. The need for autograft substitutes has led to the development of a wide variety of skeletal substitute materials that are being introduced rapidly into skeletal surgery and are thus likely to be visualized with increasing frequency by radiologists and pathologists. These materials vary with respect to composition, biologic properties, mechanical strength, and radiographic appearance.

Several important terms have been developed...

References

  1. 1.
    Bauer TW, Muschler GF. Bone graft materials: an overview of the basic science. Clin Orthop 2000; 371: 10–27.PubMedCrossRefGoogle Scholar
  2. 2.
    Muschler GF, Lane JM. Orthopedic surgery. In: Habal MB, Reddi AH, eds. Bone grafts and bone substitutes. Philadelphia: Saunders; 1992: 375–407.Google Scholar
  3. 3.
    Urist MR. Bone formation by autoinduction. Science 1965; 150: 893–894.PubMedCrossRefGoogle Scholar
  4. 4.
    Bauer TW. An overview of the histology of skeletal substitute materials. Arch Pathol Lab Med 2007; 131: 217–224.PubMedGoogle Scholar
  5. 5.
    Yoon ST, Boden SD. Osteoinductive cytokines in orthopedics: basic science and preclinical studies. Clin Orthop 2002; 395: 33–43.PubMedCrossRefGoogle Scholar
  6. 6.
    Muschler GF, Nakamoto C, Griffith LG. Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 2004; 86: 1541–1558.PubMedGoogle Scholar
  7. 7.
    Seeherman H, Li R, Bouxsein M, et al. RhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations. J Bone Joint Surg Am 2006; 88: 144–160.PubMedCrossRefGoogle Scholar

Copyright information

© ISS 2007

Authors and Affiliations

  1. 1.Pathology, Orthopaedic Surgery, and The Spine InstituteThe Cleveland Clinic FoundationClevelandUSA

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