Skip to main content

Advertisement

SpringerLink
Log in

Skeletal recurrences and metastases of extraskeletal myxoid chondrosarcoma

  • Scientific Article
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

Objective

The objective was to elucidate clinical and imaging features of skeletal involvement, recurrences, and metastases of extraskeletal myxoid chondrosarcoma.

Materials and methods

Included in this series are 4 patients, aged 44 to 65 years, 3 of whom were men and 1 a woman.

Results

The primary lesions were in the thigh (n = 3) and the upper arm (n = 1). Three patients with multiple metastases died of the disease, 2 were considered to have local recurrence in the adjacent bone. Skeletal metastases occurred after lung metastases in 2 cases, and before lung metastases in 1 case. Typical imaging findings are well-defined lesions with no sclerotic margin or matrix mineralization. A slow, but persistent growth is noted on the imaging features.

Conclusion

Although skeletal metastases of chondrosarcoma of bone and soft tissue are rare, myxoid chondrosarcomas, currently classified tumors of uncertain differentiation, rarely metastasize and/or recur in the bones. The imaging features are typically of a localized lesion with cortical disruption or expansion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Paget S. The distribution of secondary growth in cancer of the breast. Lancet 1889;1: 571–573.

    Article  Google Scholar 

  2. Ewing JA. A treatise on tumor, 3rd ed. Philadelphia: Saunders, 1928. pp 77–89.

    Google Scholar 

  3. Fletcher CDM, Unni KK, Mertens F. World Health Organization classification of tumors. Pathology and genetics of tumors of soft tissue and bone. Lyon: IARC Press, 2002.

    Google Scholar 

  4. Takeda A, Tsuchiya H, Mori Y, Nonomura A, Tomita K. Extraskeletal myxoid chondrosarcoma with multiple skeletal metastases. J Orthop Sci 2000;5: 171–174.

    Article  PubMed  CAS  Google Scholar 

  5. Enzinger FM, Shiraki M. Extraskeletal myxoid chondrosarcoma: an analysis of 34 cases. Hum Pathol 1972;3: 421–435.

    PubMed  CAS  Google Scholar 

  6. Hinrichs SH, Jaramillo MA, Gumerlock PH, Gardner MB, Lewis JP, Freeman AE. Myxoid chondrosarcoma with a translocation involving chromosomes 9 and 22. Cancer Genet Cytogenet 1985;14: 219–296.

    Article  PubMed  CAS  Google Scholar 

  7. Turc-Carel C, Dal Cin P, Rao U, Karakousis C, Sandberg AA. Recurrent break points at 9q31 and 22q12.2 in extraskeletal myxoid chondrosarcoma. Cancer Genet Cytogenet 1988;30: 145–150.

    Article  PubMed  CAS  Google Scholar 

  8. Hisaoka M, Hashimoto H. Extraskeletal myxoid chondrosarcoma: updated clinicopathological and molecular genetic characteristics. Pathol Int 2005;55: 453–463.

    Article  PubMed  Google Scholar 

  9. Bjerkehagen B, Dietrich C, Reed W, et al. Extraskeletal myxoid chondrosarcoma: multimodal diagnosis and identification of a new cytogenetic subgroup characterized by t(9;17)(q22;q11). Virchows Arch 1999;435: 524–530.

    Article  Google Scholar 

  10. Saleh G, Evans HL, Ro JY, Ayala AG. Extraskeletal myxoid chondrosarcoma. A clinicopathologic study of ten patients with long term follow-up. Cancer 1992;70: 2827–2830.

    Article  PubMed  CAS  Google Scholar 

  11. Meis-Kindblom JM, Bergh P, Gunterburg B, Kindblom L-G. Extraskeletal myxoid chondrosarcoma: a reappraisal of its morphologic spectrum and prognostic factors based on 117 cases. Am J Surg Path 1999;23: 636–650.

    Article  PubMed  CAS  Google Scholar 

  12. Disler DG, Rosenberg AE, Springfield D, O’Connell JX, Rosenthal DI, Kattapuram SV. Extensive skeletal metastases from chondrosarcoma without pulmonary involvement. Skeletal Radiol 1993;22: 595–599.

    Article  PubMed  CAS  Google Scholar 

  13. Oliveira AM, Sebo TJ, McGrory JE, Gaffey TA, Rock MG, Nascimento AG. Extraskeletal myxoid chondrosarcoma: a clinicopathologic, immunohistochemical, and ploidy analysis of 23 cases. Mod Pathol 2000;13: 900–908.

    Article  PubMed  CAS  Google Scholar 

  14. Kawaguchi S, Wada T, Nagoya S, et al. Extraskeletal myxoid chondrosarcoma: a multi-institutional study of 42 cases in Japan. Cancer 2003;97: 1285–1292.

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

This paper is partly supported by the Grant-in-Aid for Scientific Research, Ministry of Education, Culture, Sports, Science and Technology Government of Japan (17591284).

Author information

Author notes

  1. Hiroshi Yoshioka

    Present address: Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

  2. Hisashi Sumiya

    Present address: Yawata Medical Center, Komatsu, Japan

Authors and Affiliations

  1. Department of Radiology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, 020-8505, Japan

    Shigeru Ehara

  2. Department of Orthopedic Surgery, Iwate Medical University School of Medicine, Iwate, Japan

    Jun Nishida & Hideo Shiraishi

  3. Department of Radiology, University of Tsukuba School of Medicine, Tsukuba, Japan

    Hiroshi Yoshioka

  4. Department of Orthopedic Surgery, Akita University School of Medicine, Akita, Japan

    Kyoji Okada

  5. Department of Nuclear Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

    Hisashi Sumiya

  6. Division of Diagnostic Imaging, Chiba Cancer Center, Chiba, Japan

    Hideyuki Takano

Authors
  1. Shigeru Ehara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jun Nishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hideo Shiraishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hiroshi Yoshioka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kyoji Okada
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hisashi Sumiya
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hideyuki Takano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shigeru Ehara.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ehara, S., Nishida, J., Shiraishi, H. et al. Skeletal recurrences and metastases of extraskeletal myxoid chondrosarcoma. Skeletal Radiol 36, 823–827 (2007). https://doi.org/10.1007/s00256-007-0303-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-007-0303-9

Keywords

Search

Navigation