Skip to main content

Advertisement

SpringerLink
Log in

Dynamic contrast-enhanced perfusion MR imaging of diseased vertebrae: analysis of three parameters and the distribution of the time-intensity curve patterns

  • Scientific Article
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

Objective

To assess the diagnostic value of perfusion MR imaging of diseased vertebrae by analysis of three parameters and the distribution of the time-intensity curve (TIC) patterns.

Design and patients

Dynamic MR imaging was performed on 34 patients with 48 lesions. All lesions were assigned to one of four groups: osteoporotic compression fracture, benign lesion without compression fracture, pathologic compression fracture, or metastatic lesion without fracture. Peak enhancement, steepest slope, and slope value were calculated from the TIC of diseased vertebrae. TICs were classified into five types. Comparisons were made among groups by analysis of the three parameters and the distributions of the TICs pattern.

Result

All parameters of pathologic compression fracture were significantly higher than those of osteoporotic compression fracture (P<0.05). The steepest slopes of metastatic lesions with and without pathologic compression fracture were significantly higher than those of benign lesions without compression fracture (P<0.05). No characteristic distribution of the TIC pattern helpful for the differentiation of benign and metastatic lesions was found.

Conclusion

In distinguishing osteoporotic from pathologic compression fractures, semiquantitative analysis of the perfusion MR imaging may be useful. However, the analysis of the TIC patterns can not significantly contribute to the differential diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3A―D

Similar content being viewed by others

References

  1. Totty WG, Murphy WA, Lee JKT. Soft tissue tumors: MR imaging. Radiology 1986; 160:135–141.

    PubMed  Google Scholar 

  2. Crim JR, Seeger LL, Yao L, et al. Diagnosis of soft-tissue masses be differentiated from malignant ones? Radiology 1992;185: 581–586.

    PubMed  Google Scholar 

  3. Sundaram M, McGuire MH, Schajowicz F. Soft-tissue masses: histologic basis for decreased signal (short T2) on T2-weighted images. AJR Am J Roentgenol 1987; 148:1247–1250.

    PubMed  Google Scholar 

  4. Erlemann R, Reiser MF, Peters PE, et al. Musculoskeletal neoplasm: static and dynamic Gd-DTPA-enhanced MR imaging. Radiology 1989; 171:767–773.

    PubMed  Google Scholar 

  5. Erlemann R, Sciuk J, Bosse A, et al. Response of osteosarcoma and Ewing sarcoma to preoperative chemotherapy assessment with dynamic and static MR imaging and skeletal scintigraphy. Radiology 1990; 175:791–796.

    PubMed  Google Scholar 

  6. Verstraete KL, De Deene Y, Roels H, et al. Benign and malignant musculoskeletal lesion: dynamic contrast-enhanced MR imaging-parametric “first-pass” images depict tissue vascularization and perfusion. Radiology 1994; 192:835–843.

    PubMed  Google Scholar 

  7. Cova M, Kang YS, Tsukamoto H, et al. Bone marrow perfusion evaluated with gadolinium-enhanced dynamic fast MR imaging in a dog model. Radiology 1991; 179:535–539.

    PubMed  Google Scholar 

  8. Fletcher BD, Hanna SL, Fairclough DJ, et al. Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy. Radiology 1992; 184:243–248.

    PubMed  Google Scholar 

  9. Van Der Woude HJ, Verstraete KL, Hoendoorn PC, Taminiau AH, Hermans J, Bloem JL. Musculoskeletal tumors: does fast dynamic contrast-enhanced subtraction MR imaging contribute to the characterization? Radiology 1998; 208:821–828.

    PubMed  Google Scholar 

  10. Bollow VM, Knauf W, Korfel A, et al. Initial experience with dynamic MR imaging in evaluation of normal bone marrow versus malignant bone marrow infiltrations in humans. J Magn Reson Imaging 1997; 7:241–250.

    PubMed  Google Scholar 

  11. Konig H, Sieper J, Wolf K. Rheumatoid arthritis: evaluation of hypervascular and fibrous pannus with dynamic MR imaging enhanced with Gd-DTPA. Radiology 1990; 176:473–477.

    PubMed  Google Scholar 

  12. Verstraete KL, Van der Woude HJ, Hogendoorn PC, et al. Dynamic contrast-enhanced MR imaging of musculoskeletal tumors: basic principles and clinical applications. J Magn Reson Imaging 1996; 6:311–321.

    PubMed  Google Scholar 

  13. Chen WT, Shih TT, Chen RC, et al. Blood perfusion of vertebral lesions evaluated with gadolinium-enhanced dynamic MRI: in comparison with compression fracture and metastasis. J Magn Reson Imaging 2002; 15:308–314.

    Article  PubMed  Google Scholar 

  14. Shin TT, Huang KM, Li YW. Solitary vertebral collapse: distinction between and malignant causes using MR patterns. J Magn Reson Imaging 1999; 9:635–642.

    Article  PubMed  Google Scholar 

  15. Yuh WTC, Zachar CK, Barloon TJ, et al. Vertebral compression fractures: distinction between benign and malignant causes with MR imaging. Radiology 1989; 172:215–218.

    PubMed  Google Scholar 

  16. Shin TT, Tsuang YH, Huang KM, et al. Magnetic resonance imaging of vertebral compression fractures. J Formos Med Assoc 1996; 95:313–319.

    PubMed  Google Scholar 

  17. Chen WT, Shih TTF, Chen RC, Lo SY, Chou CT, Lee JM, et al. Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MR imaging: significance of aging and sex. Radiology 2001; 220:213–218.

    PubMed  Google Scholar 

  18. Wolf GL. Contrast agents in spine and body MRI: introduction. In: Hasso AN, Stark DD, eds. American Roentgen Ray Society—Categorical course syllabus: spine and body magnetic resonance imaging—1991. Reston, VA: American Roentgen Ray Society, 1991:11–115.

  19. Chen WT, Shin TTF, Chen RC, Lo SY, Chou CT, Lee JM, Tu HY. Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MR imaging: significance of aging and sex. Radiology 2001; 220:213–218.

    PubMed  Google Scholar 

  20. Montazel JL, Divine M, Lepage E, Kobeiter H, Breil S, Rahmouni A. Normal spinal bone marrow in adults: dynamic gadolinium-enhanced MR imaging. Radiology 2003; 229:703–709.

    PubMed  Google Scholar 

  21. Baker LL, Goodman SB, Perkash I, Lane B, Enzman DR. Benign versus pathologic compression fractures of vertebral bodies: assessment with conventional spine-echo, chemical shift , and STIR imaging. Radiology 1990; 174:495–502.

    PubMed  Google Scholar 

  22. Baur A, Stabler A, Bruning R, Bartl R, Krodel A, Reiser M, Deimling M. Diffusion-weighted MR imaging of bone marrow: differentiation benign versus pathologic compression fractures. Radiology 1998; 207:349-356.

    PubMed  Google Scholar 

  23. Spuentrup E, Buecker A, Adam G, van Vaals J, Guenther RW. Diffusion-weighted MR imaging for differentiation of benign fracture edema and tumor infiltration of the vertebral body. AJR Am J Roentgenol 2001; 176:351–358.

    PubMed  Google Scholar 

  24. Cruses RL, Dumount J. Healing of bone, tendon and ligament. In: Rockwood Jr CA, Green DP, eds. Fractures. Philadelphia: JB Lippincott, 1975:97–98.

Download references

Acknowledgement

Our grateful thanks go to Shuuichi Yamauchi and Kumi Ishihara, who were responsible for production of the MR images.

Author information

Authors and Affiliations

  1. Department of Radiology, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, 755-8505, Yamaguchi, Japan

    Osamu Tokuda, Noriko Hayashi, Koutarou Taguchi & Naofumi Matsunaga

Authors
  1. Osamu Tokuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Noriko Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Koutarou Taguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Naofumi Matsunaga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Osamu Tokuda.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tokuda, O., Hayashi, N., Taguchi, K. et al. Dynamic contrast-enhanced perfusion MR imaging of diseased vertebrae: analysis of three parameters and the distribution of the time-intensity curve patterns. Skeletal Radiol 34, 632–638 (2005). https://doi.org/10.1007/s00256-005-0949-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-005-0949-0

Keywords

Search

Navigation