Abstract
We present two cases of sclerosing perineurioma, a rare soft tissue tumor, in the palm and the ring finger respectively, presenting as a small, painless and subcutaneous mass. This tumor has a predilection for the digits and palms of young, predominantly male adults. In the present cases the tumors showed very low signal intensity on T2-weighted magnetic resonance (MR) images. Histologically they contained abundant collagen and hyalinized stroma, which would account for areas of low signal intensity on T2-weighted MR images. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen and human erythrocyte glucose transporter 1 and negative for S-100 protein. To the best of our knowledge, the appearance of sclerosing perineurioma on MR imaging has not been previously reported in the English-language literature. Sclerosing perineurioma should be considered in the differential diagnosis of hand tumors when the tumor shows low signal intensity on T2-weighted MR images.
References
Lazarus SS, Trombetta LD. Ultrastructural identification of a benign perineurial cell tumor. Cancer 1978;41:1823–9
Fetsch JF, Miettinen M. Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults. Am J Surg Pathol 1997;21:1433–42
Yamaguchi U, Hasegawa T, Hirose T, et al. Sclerosing perineurioma: a clinicopathological study of five cases and diagnostic utility of immunohistochemical staining for GLUT1. Virchows Arch 2003;443:159–63
Canales-Ibarra C, Magarinos G, Olsoff-Pagovich P, Ortiz-Hidalgo C. Cutaneous sclerosing perineurioma of the digits: an uncommon soft-tissue neoplasm. Report of two cases with immunohistochemical analysis. J Cutan Pathol 2003;30:577–81
Huang HY, Sung MT. Sclerosing perineuriomas affecting bilateral hands. Br J Dermatol 2002;146:129–33
Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/GLUT1-positive perineurial cells and CD34 positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol 2003;116:293–8
Sundaram M, McGuire MH, Schajowicz F. Soft tissue masses: histologic basis for decreased signal (short T2) on T2-weighted MR images. AJR 1987;148:1247–50
Karasick D, Karasick S. Giant cell tumor of tendon sheath: spectrum of radiologic findings. Skelet Radiol 1992;21:219–24
Horcajadas AB, Lafuente JL, de la Cruz Burgos R, et al. Ultrasound and MR findings in tumor and tumor-like lesions of the fingers. Eur Radiol 2003;13:672–85
Kato K, Ehara S, Nishida J, et al. Rapid involution of proliferative fasciitis. Skelet Radiol 2004;33:300–2
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Miyake, M., Tateishi, U., Maeda, T. et al. Sclerosing perineurioma: tumor of the hand with a short T2. Skeletal Radiol 35, 543–546 (2006). https://doi.org/10.1007/s00256-005-0037-5
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DOI: https://doi.org/10.1007/s00256-005-0037-5