Abstract
Primary leiomyosarcoma of bone is a rare malignant tumor of smooth muscle. We report a case of low-grade subperiosteal primary bone leiomyosarcoma in the tibial diaphysis, which radiologically appeared to be osteoid osteoma. A 35-year-old man presented with a several-year history of a palpable hard nodule in the distal left leg, which had enlarged and become painful over the previous 2 years. Radiographs showed solid periosteal reaction with a well-defined lytic lesion in the posteromedial cortical border of the left tibial diaphysis. Computed tomography demonstrated a small, well-defined lytic lesion, not calcified, in a subperiosteal location, surrounded by solid periosteal bone formation. The lesion was excised en bloc and the histological diagnosis of a low-grade leiomyosarcoma was made. To the best of our knowledge, the surface location of primary bone leiomyosarcoma has not been previously described in the literature.
Similar content being viewed by others
References
Fornasier VL, Paley D. Leiomyosarcoma of bone: primary or secondary? Skeletal Radiol 1983; 10:147―153.
Jeanrot C, Ouaknine M, Anract P, Carlioz A, Forest M, Tomeno B. Leiomyosarcome primitif osseux. Presentation de cinq observations anatomo-cliniques et revue de la litterature. Rev Chir Pathol 2000; 86:63―73.
Evans DMD, Sanerkin NG. Primary leiomyosarcoma of bone. J Pathol Bacteriol 1965; 90:348―350.
Berlin O, Angervall L, Kindblom LG, Berlin IC, Stener B. Primary leiomyosarcoma of bone. A clinical, radiographic, pathologic-anatomic, and prognostic study of 16 cases. Skeletal Radiol 1987; 16:364―376.
Myers JL, Arocho J, Bernreuter W, Dunham W, Mazur MT. Leiomyosarcoma of bone. A clinicopathologic, immunohistochemical, and ultrastructural study of five cases. Cancer 1991; 67:1051―1056.
Jundt G, Moll C, Nidecker A, Schilt R, Remagen W. Primary leiomyosarcoma of bone: report of eight cases. Hum Pathol 1994; 25:1205―1212.
Khoddami M, Bedard YC, Bell RS, Kandel RA. Primary leiomyosarcoma of bone. Report of seven cases and review of the literature. Arch Pathol Lab Med 1996; 120:671―675.
Antonescu CR, Erlandson RA, Huvos AG. Primary leiomyosarcoma of bone: a clinicopathologic, immunohistochemical, and ultrastructural study of 33 patients and a literature review. Am J Surg Pathol 1997; 21:1281―1294.
Wirbel RJ, Verelst S, Hanselmann R, Remberger K, Kubale R, Mutschler WE. Primary leiomyosarcoma of bone: clinicopathologic, immunohistochemical, and molecular biologic aspects. Ann Surg Oncol 1998; 5:635―641.
Sundaram M, Akduman I, White LM, McDonald DJ, Kandel R, Janney C. Primary leiomyosarcoma of bone. AJR Am J Roentgenol 1999; 172:771―776.
Bush CH, Reith JD, Spanier SS. Mineralization in musculoskeletal leiomyosarcoma: radiologic-pathologic correlation. AJR Am J Roentgenol 2003; 180:109―113.
Meister P, Konrad E, Gokel JM, Remberger K. Case report 59. Leiomyosarcoma of the humerus. Skeletal Radiol 1978; 2:265―267.
Abdelwahab IF, Hermann G, Kenan S, Klein MJ, Lewis MM. Case report 794. Primary leiomyosarcoma of the right femur. Skeletal Radiol 1993; 22:379―381.
Akata D, Aralasmak A, Ozmen MN, Akhan O, Altundag K, Gullu I. US and CT findings of multicentric leiomyosarcomatosis. Eur Radiol 1999; 9:711―714.
Inoue S, Tanaka K, Sakamoto A, Matsuda S, Tsuneyoshi M, Iwamoto Y. Primary leiomyosarcoma of the patella. Skeletal Radiol 2001; 30:530―533.
Shen SH, Steinbach LS, Wang SF, Chen WY, Chen WM, Chang CY. Primary leiomyosarcoma of bone. Skeletal Radiol 2001; 30:600―603.
Ganau S, Tomas X, Mallofre C, Macho JM, Pomes J, Combalia A. Leiomyosarcoma of sacrum: imaging and histopathologic findings. Eur Radiol 2002; 12 (Suppl 3):S35―S39.
Kaiser F, Resnick D, Haghighi P. Evidence of the subperiosteal origin of osteoid osteoma in tubular bones: analysis by CT and MR imaging. AJR Am J Roentgenol 1998; 170:609―614.
Seeger LL, Yao L, Eckardt JJ. Surface lesions of bone. Radiology 1998; 206:17―33.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Narváez, J.A., De Lama, E., Portabella, F. et al. Subperiosteal leiomyosarcoma of the tibia. Skeletal Radiol 34, 42–46 (2005). https://doi.org/10.1007/s00256-004-0838-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00256-004-0838-y